Hypothyroidism Protects Rat Liver from Acetaminophen Hepatotoxicity

[1]  N. Hilzenrat,et al.  Hemodynamic effects of hypothyroidism induced by methimazole in normal and portal hypertensive rats , 1993, Digestive Diseases and Sciences.

[2]  Laura P James,et al.  Acetaminophen-induced hepatotoxicity. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[3]  Z. Halpern,et al.  Inhibition of concanavalin A-induced acute T cell dependent hepatic damage in mice by hypothyroidism. , 1999, Liver.

[4]  C. McClain,et al.  Acetaminophen hepatotoxicity: new insights , 1998 .

[5]  P. Thomas,et al.  Role of nitric oxide in acetaminophen‐induced hepatotoxicity in the rat , 1998, Hepatology.

[6]  K. Lindros,et al.  Zonation of hepatic cytochrome P-450 expression and regulation. , 1998, The Biochemical journal.

[7]  Z. Halpern,et al.  Inhibition of experimentally induced cirrhosis in rats by hypothyroidism , 1996, Hepatology.

[8]  R. Wilson,et al.  Role of proinflammatory cytokines in acetaminophen hepatotoxicity. , 1995, Toxicology and applied pharmacology.

[9]  M. Czaja,et al.  Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor. , 1995, Gastroenterology.

[10]  Y. Israel,et al.  Effect of propylthiouracil on the ethanol‐induced increase in liver oxygen consumption in awake rats , 1993, Hepatology.

[11]  G. Alexander,et al.  Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine , 1990, The Lancet.

[12]  Y. Israel,et al.  Effects of propylthiouracil and methimazole on splanchnic hemodynamics in awake and unrestrained rats , 1989, Hepatology.

[13]  J. Boyer,et al.  Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver , 1989, Hepatology.

[14]  Y. Park,et al.  Prevention of acetaminophen-induced hepatotoxicity by dimethyl sulfoxide. , 1988, Toxicology.

[15]  Y. Israel,et al.  LONG-TERM TREATMENT OF ALCOHOLIC LIVER DISEASE WITH PROPYLTHIOURACIL , 1988, The Lancet.

[16]  D. Samuel,et al.  Emergency liver transplantation for fulminant hepatitis. , 1987, Annals of internal medicine.

[17]  D. Laskin,et al.  Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver. , 1986, Toxicology and applied pharmacology.

[18]  D. Laskin,et al.  Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation. , 1986, Toxicology and applied pharmacology.

[19]  M. Davis Protective Agents for Acetaminophen Overdose , 1986, Seminars in liver disease.

[20]  W. Siede,et al.  Effect of hypometabolism on cell injury. , 1986, Klinische Wochenschrift.

[21]  J. Tempowski,et al.  Adverse reactions to acetylcysteine and effects of overdose. , 1984, British medical journal.

[22]  G. Malvaldi,et al.  Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide. , 1984, Toxicology.

[23]  Jerry R. Mitchell,et al.  Toxic Doses of Acetaminophen Suppress Hepatic Glutathione Synthesis in Rats , 2007, Hepatology.

[24]  G. Kanel,et al.  Double-blind, controlled trial of propylthiouracil in patients with severe acute alcoholic hepatitis. , 1982, Gastroenterology.

[25]  R. Hilf,et al.  A fluorometric method for determination of oxidized and reduced glutathione in tissues. , 1976, Analytical biochemistry.

[26]  S. Thorgeirsson,et al.  Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. , 1974, Pharmacology.

[27]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. , 1973, The Journal of pharmacology and experimental therapeutics.

[28]  B. Brodie,et al.  ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. III. CYTOCHROME P-450-MEDIATED COVALENT BINDING IN VITRO , 1973 .

[29]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. , 1973, The Journal of pharmacology and experimental therapeutics.