Clinical Outcomes of Ultrasound-Guided Transmeniscal Injection in Medial Compartment Knee Osteoarthritis

Purpose: The purpose of this study was to introduce the ultrasound-guided transmeniscal injection in medial compartment knee osteoarthritis and analyze the clinical outcomes. Materials and Methods: The electronic medical records of 36 patients with medial compartment knee osteoarthritis who were treated with an ultrasound-guided transmeniscal injection from March 2019 to July 2019 were accessed for this retrospective review. Using an ultrasound guided spinal needle, the patients received an intra-articular steroid injection at the medial compartment of the knee. A physical examination was conducted at the initial visit (pre-injection), and at one week, four weeks, and eight weeks after the injection. The numeric pain rating scale (NRS), Lequesne index, and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) score were measured at each visit and analyzed over time. The percentage change of the patients who revealed substantial improvement was analyzed. The NRS, Lequesne index, and percentage of patients, who revealed substantial improvement over time classified by osteoarthritis grade, were analyzed. Results: The NRS and Lequesne index decreased at one week, four weeks, and eight weeks after the injection compared to the initial baseline, and the pain-relief effect continued without change until eight weeks. The percentage of patients who showed substantial improvement at one, four, and eight weeks was 50.0%, 47.2%, and 52.8%, respectively. The WOMAC scores decreased at one, four, and eight weeks compared to the initial baseline, and the decrease was continued without any difference until eight weeks. The percentage of patients with osteoarthritis stage 1 or 2 who revealed more than substantial improvement was significantly higher at one, four, and eight weeks than those with osteoarthritis stages 3 or 4 (p<0.05). Conclusion: In patients with medial compartment knee osteoarthritis, the pain reduction and functional improvement persisted for at least eight weeks after the ultrasound-guided transmeniscal injection at the medial compartment. In particular, patients with medial compartment osteoarthritis stage 1 or 2 showed more effective pain reduction.

[1]  C. Meaney,et al.  Meniscus‐Targeted Injections for Chronic Knee Pain Due to Meniscal Tears or Degenerative Fraying: A Retrospective Study , 2019, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[2]  E. Matzkin,et al.  Efficacy and Treatment Response of Intra-articular Corticosteroid Injections in Patients With Symptomatic Knee Osteoarthritis , 2017, The Journal of the American Academy of Orthopaedic Surgeons.

[3]  B. Fregly,et al.  The Pathophysiology of Osteoarthritis: A Mechanical Perspective on the Knee Joint , 2012, PM & R : the journal of injury, function, and rehabilitation.

[4]  D. Berkoff,et al.  Clinical utility of ultrasound guidance for intra-articular knee injections: a review , 2012, Clinical interventions in aging.

[5]  P Tugwell,et al.  OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. , 2010, Osteoarthritis and cartilage.

[6]  Raveendhara R. Bannuru,et al.  Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis. , 2009, Arthritis and rheumatism.

[7]  Sung-Rae Cho,et al.  Feasibility of Sonography for Intra‐articular Injections in the Knee Through a Medial Patellar Portal , 2009, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[8]  S. Jacobsen,et al.  Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders. , 2008, Journal of pharmaceutical sciences.

[9]  K. Jordan,et al.  A randomised controlled trial of tidal irrigation vs corticosteroid injection in knee osteoarthritis: the KIVIS Study. , 2008, Osteoarthritis and cartilage.

[10]  David Cella,et al.  Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. , 2008, The journal of pain : official journal of the American Pain Society.

[11]  P. Lafforgue,et al.  Placement of intra-articular injection verified by the backflow technique. , 2006, Osteoarthritis and cartilage.

[12]  J. Farrar,et al.  Core outcome measures for chronic pain clinical trials: IMMPACT recommendations , 2003, Pain.

[13]  N. Bellamy,et al.  Intraarticular corticosteroid for treatment of osteoarthritis of the knee. , 2005, The Cochrane database of systematic reviews.

[14]  B. Arroll,et al.  Corticosteroid injections for osteoarthritis of the knee: meta-analysis , 2004, BMJ : British Medical Journal.

[15]  H. Dabke Accuracy of needle placement into the intra-articular space of the knee. , 2004, The Journal of bone and joint surgery. American volume.

[16]  A. Esterman,et al.  A randomized placebo-controlled trial of arthroscopic lavage versus lavage plus intra-articular corticosteroids in the management of symptomatic osteoarthritis of the knee. , 2003, Rheumatology.

[17]  J. Raynauld,et al.  Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. , 2003, Arthritis and rheumatism.

[18]  M. Lequesne,et al.  Comparison between the WOMAC and the Lequesne indices in patients with knee and hip osteoarthritis. , 1998, Osteoarthritis and cartilage.

[19]  J. Pelletier,et al.  Proteoglycan-degrading acid metalloprotease activity in human osteoarthritic cartilage, and the effect of intraarticular steroid injections. , 1987, Arthritis and rheumatism.

[20]  J. Kellgren,et al.  Radiological Assessment of Osteo-Arthrosis , 1957, Annals of the rheumatic diseases.