Computer Applications to Fermentation Processes

Publisher Summary This chapter discusses modeling, control, and parameter estimation for computer-coupled fermentors and, in particular, explores the area of fermentation optimization. The chapter presents, using the Purdue system as an example, a description of the important features of computer-coupled fermentors for use in academic and institutional environments, where usually more fundamental engineering questions are examined. The report by Dobry and Jost elaborated on the choices in design and system requirements of a computer-coupled fermentation system emphasizing features needed for industrial purposes. Similar feelings on this topic have been expressed by Jefferis. Also, much information on the efforts at standardizing the software and hardware interfaces for computer control can be found in the annual reports of workshops held by the Purdue Laboratory for Applied Industrial Control headed by T. J. Williams. The current system at Purdue was designed to permit considerable flexibility and accuracy with relative ease of operation.

[1]  A Constantinides,et al.  Optimization of batch fermentation processes. II. Optimum temperature profiles for batch penicillin fermentations , 1970, Biotechnology and bioengineering.

[2]  A Constantinides,et al.  Optimization of batch fermentation processes. I. Development of mathematical models for batch penicillin fermentations. , 1970, Biotechnology and bioengineering.

[3]  E. M. L. Beale,et al.  Nonlinear and Dynamic Programming , 1965 .

[4]  L. S. Pontryagin,et al.  Mathematical Theory of Optimal Processes , 1962 .

[5]  G. D'Ans,et al.  Time-optimal control for a model of bacterial growth , 1971 .

[6]  Alan S. Foss.  Critique of chemical process control theory , 1973 .

[7]  Marvin Charles,et al.  On‐line measurement of gas‐exchange conditions in fermentation processes , 1975 .

[8]  Hiromu Ohno,et al.  Theory and practice of optimal control in continuous fermentation process , 1975 .

[9]  Arthur E. Bryson,et al.  OPTIMAL PROGRAMMING PROBLEMS WITH INEQUALITY CONSTRAINTS , 1963 .

[10]  S Nagai,et al.  Fed batch culture of Saccharomyces cerevisiae: A perspective of computer control to enhance the productivity in baker's yeast cultivation , 1976, Biotechnology and bioengineering.

[11]  Arthur E. Humphrey,et al.  Real‐time estimation of aerobic batch fermentation biomass concentration by component balancing , 1978 .

[12]  John F. Andrews,et al.  A mathematical model for the continuous culture of microorganisms utilizing inhibitory substrates , 1968 .

[13]  H. Blanch,et al.  Optimal conditions for gramicidin S production in continuous culture , 1972, Biotechnology and bioengineering.

[14]  Petar V. Kokotovic,et al.  Optimal Control of Bacterial Growth , 1972 .

[15]  Leon Lapidus,et al.  Optimal control of engineering processes , 1967 .

[16]  W. A. Weigand.  Optimal Control of a Plug-Flow Heat Exchanger with Control Produced by Wall Flux or Wall Temperature , 1970 .

[17]  W. A. Weigand,et al.  INVESTIGATION OF A METHOD FOR THE TIME OPTIMAL CONTROL OF LINEAR SYSTEMS WITH MULTIPLE INPUTS , 1975 .

[18]  A. F. D’Souza,et al.  Optimal Control of Linear Distributed Parameter Systems With Constrained Inputs , 1969 .

[19]  Petar V. Kokotovic,et al.  A nonlinear regulator problem for a model of biological waste treatment , 1971 .

[20]  A. Constantinides,et al.  Specific optimal control of a batch fermentor , 1974 .

[21]  Henry Y. Wang,et al.  Computer‐aided baker's yeast fermentations , 1977, Biotechnology and bioengineering.

[22]  G. Bliss.  Lectures on the calculus of variations , 1946 .

[23]  M. Denn.  Optimization by variational methods , 1969 .

[24]  Tsuneo Yamane,et al.  A Simple Optimization Technique for Fed-batch Culture : Kinetic Studies on Fed-batch Cultures (VI) , 1977 .

[25]  W Y Svrcek,et al.  The extended Kalman filter applied to a continuous culture model , 1974, Biotechnology and bioengineering.

[26]  Gordon S. G. Beveridge,et al.  Optimization: theory and practice , 1970 .

[27]  G. F. Newell,et al.  The variational method in engineering , 1968 .

[28]  M. J. Box.  A New Method of Constrained Optimization and a Comparison With Other Methods , 1965, Comput. J..

[29]  Clarence Zener,et al.  Geometric Programming , 1974 .

[30]  Vern W. Weekman,et al.  Advanced control practice in the chemical process industry: A view from industry , 1976 .

[31]  P Whaite,et al.  On-line computer optimization of chemostat productivity. , 1977, Biotechnology and bioengineering.

[32]  A. Feinstein,et al.  Variational Methods for the Study of Nonlinear Operators , 1966 .

[33]  Hiromu Ohno,et al.  Optimum operating mode for a class of fermentation , 1978 .

[34]  T. Takamatsu,et al.  Optimal control of a semibatch fermentation , 1976, Biotechnology and bioengineering.