A Conceptual Model for Segmentation of Multiple Scleroses Lesions in Magnetic Resonance Images Using Massive Training Artificial Neural Network

Detecting abnormalities in medical images is one application of image segmentation. MRI as an imaging technique sensitive to soft tissues such as brain shows Multiple Scleroses lesions as hyper-intense or hypo-intense signals. As manual segmentation of these lesions is a laborious and time consuming task, many methods for automatic brain lesion segmentation have been proposed. To tackle difficulties of Multiple Scleroses lesion segmentation we have proposed a conceptual model based on MTANN, as a method for training artificial neural networks to detect abnormalities in medical images. The proposed model has three main phases namely, Pre-Processing, Segmentation, and False Positive/Negative Reduction. In the segmentation phase, feature extraction and selection are done automatically using MTANN. The Fuzzy Inference System reduce false positives/negatives in the last phase. As advantage of proposed model, it is supposed to produce accurate lesion mask using just FLAIR MRI that reduce computational time and brings comfort for patients.

[1]  Michael Negnevitsky,et al.  Artificial Intelligence: A Guide to Intelligent Systems , 2001 .

[2]  Christos Davatzikos,et al.  Measuring Brain Lesion Progression with a Supervised Tissue Classification System , 2008, MICCAI.

[3]  Koen L. Vincken,et al.  Probabilistic segmentation of brain tissue in MR imaging , 2005, NeuroImage.

[4]  Kenji Suzuki,et al.  A CAD utilizing 3D massive-training ANNs for detection of flat lesions in CT colonography: preliminary results , 2009, Medical Imaging.

[5]  Alex Rovira,et al.  Segmentation of multiple sclerosis lesions in brain MRI: A review of automated approaches , 2012, Inf. Sci..

[6]  Arthur W. Toga,et al.  Skull-stripping magnetic resonance brain images using a model-based level set , 2006, NeuroImage.

[7]  Koen L. Vincken,et al.  Automatic segmentation of different-sized white matter lesions by voxel probability estimation , 2004, Medical Image Anal..

[8]  Olivier Clatz,et al.  Spatial decision forests for MS lesion segmentation in multi-channel magnetic resonance images , 2011, NeuroImage.

[9]  Ying Wu,et al.  Automated segmentation of multiple sclerosis lesion subtypes with multichannel MRI , 2006, NeuroImage.

[10]  Joseph Ross Mitchell,et al.  Segmentation of multiple sclerosis lesions using support vector machines , 2003, SPIE Medical Imaging.

[11]  R. Bares,et al.  Fuzzy inference systems for segmented attenuation correction in positron emission tomography , 2000, 2000 IEEE Nuclear Science Symposium. Conference Record (Cat. No.00CH37149).

[12]  Johan H. C. Reiber,et al.  Fully automatic segmentation of white matter hyperintensities in MR images of the elderly , 2005, NeuroImage.

[13]  D. Louis Collins,et al.  Review of automatic segmentation methods of multiple sclerosis white matter lesions on conventional magnetic resonance imaging , 2013, Medical Image Anal..

[14]  Kenji Suzuki A supervised 'lesion-enhancement' filter by use of a massive-training artificial neural network (MTANN) in computer-aided diagnosis (CAD). , 2009, Physics in medicine and biology.

[15]  Yutaka Hata,et al.  Automated segmentation of human brain MR images aided by fuzzy information granulation and fuzzy inference , 2000, IEEE Trans. Syst. Man Cybern. Part C.

[16]  Kunio Doi,et al.  How can a massive training artificial neural network (MTANN) be trained with a small number of cases in the distinction between nodules and vessels in thoracic CT? , 2005, Academic radiology.

[17]  Shan Shen,et al.  An improved lesion detection approach based on similarity measurement between fuzzy intensity segmentation and spatial probability maps. , 2010, Magnetic resonance imaging.

[18]  Christian Barillot,et al.  A robust Expectation-Maximization algorithm for Multiple Sclerosis lesion segmentation , 2008, The MIDAS Journal.

[19]  G. Gerig,et al.  Automatic MS Lesion Segmentation by Outlier Detection and Information Theoretic Region Partitioning , 2008, The MIDAS Journal.

[20]  Brian B. Avants,et al.  N4ITK: Improved N3 Bias Correction , 2010, IEEE Transactions on Medical Imaging.

[21]  Christos Davatzikos,et al.  Computer-assisted Segmentation of White Matter Lesions in 3d Mr Images Using Support Vector Machine 1 , 2022 .

[22]  C. Reynolds,et al.  A fully automated method for quantifying and localizing white matter hyperintensities on MR images , 2006, Psychiatry Research: Neuroimaging.

[23]  Rita Simões,et al.  Automatic segmentation of cerebral white matter hyperintensities using only 3D FLAIR images. , 2013, Magnetic resonance imaging.

[24]  A. Kouzani,et al.  Segmentation of multiple sclerosis lesions in MR images: a review , 2011, Neuroradiology.