Constructing realistic neural simulations with GENESIS.

The GEneral NEural SImulation System (GENESIS) is an open source simulation platform for realistic modeling of systems ranging from subcellular components and biochemical reactions to detailed models of single neurons, simulations of large networks of realistic neurons, and systems-level models. The graphical interface XODUS permits the construction of a wide variety of interfaces for the control and visualization of simulations. The object-oriented scripting language allows one to easily construct and modify simulations built from the GENESIS libraries of simulation components. Here, we present procedures for installing GENESIS and its supplementary tutorials, running GENESIS simulations, and creating new neural simulations.

[1]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1990 .

[2]  R. Traub,et al.  A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. , 1991, Journal of neurophysiology.

[3]  J. Bower,et al.  Cortical oscillations and temporal interactions in a computer simulation of piriform cortex. , 1992, Journal of neurophysiology.

[4]  J. Kotaleski,et al.  Modeling The Dynamics of Second Messenger Pathways , 2003 .

[5]  D. Jaeger Accurate Reconstruction of Neuronal Morphology , 2000 .

[6]  James M. Bower,et al.  The Book of GENESIS , 1994, Springer New York.

[7]  P. Smolen,et al.  Calcium dynamics in large neuronal models , 1998 .

[8]  Pyramidal cell response to patterns of synaptic input believed to underlie gamma osillations , 1997 .

[9]  J. Bower,et al.  The Book of GENESIS , 1998, Springer New York.

[10]  J. Bower,et al.  An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. , 1994, Journal of neurophysiology.

[11]  David Beeman,et al.  GENESIS Modeling Tutorial , 2005 .

[12]  U. Bhalla Signaling in small subcellular volumes. II. Stochastic and diffusion effects on synaptic network properties. , 2004, Biophysical journal.

[13]  Bijoy K. Ghosh,et al.  Propagating Waves in Visual Cortex: A Large-Scale Model of Turtle Visual Cortex , 2003, Journal of Computational Neuroscience.

[14]  J. Bower,et al.  Feedforward inhibition controls the spread of granule cell-induced Purkinje cell activity in the cerebellar cortex. , 2007, Journal of neurophysiology.

[15]  U. Bhalla,et al.  Emergent properties of networks of biological signaling pathways. , 1999, Science.