Integration of polymer microfluidic channels, vias, and connectors with silicon photonic sensors by one-step combined photopatterning and molding of OSTE

We demonstrate a method for the fast and simple packaging of silicon sensors into a microfluidic package consisting of the recently introduced OSTE polymer. The microfluidic layer is first microstructured and thereafter dry-bonded to a silicon photonic sensor, in a process compatible with wafer-level production, and with the entire packaging process lasting only 10 minutes. The fluidic layer combines molded microchannels and fluidic (Luer) connectors with photopatterned through-holes (vias) for optical fiber probing and fluid connections. All the features are fabricated in a single photocuring step. We report measurements with an integrated silicon photonic Mach-Zehnder interferometer refractive index sensor packaged by these means.

[1]  Wouter van der Wijngaart,et al.  Beyond PDMS: off-stoichiometry thiol-ene (OSTE) based soft lithography for rapid prototyping of microfluidic devices. , 2011, Lab on a chip.

[2]  R. Baets,et al.  Multiplexed Antibody Detection With an Array of Silicon-on-Insulator Microring Resonators , 2009, IEEE Photonics Journal.

[3]  D. Beebe,et al.  Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays , 2008, BioEssays : news and reviews in molecular, cellular and developmental biology.

[4]  Wouter van der Wijngaart,et al.  Biocompatible "click" wafer bonding for microfluidic devices. , 2012, Lab on a chip.

[5]  Gengfeng Zheng,et al.  Multiplexed electrical detection of cancer markers with nanowire sensor arrays , 2005, Nature Biotechnology.

[6]  Farizah Saharil,et al.  HIGH-RESOLUTION MICROPATTERNING OF OFF-STOCHIOMETRIC THIOL-ENES (OSTE) VIA A NOVEL LITHOGRAPHY MECHANISM , 2012 .

[7]  Ryan C Bailey,et al.  High-Q optical sensors for chemical and biological analysis. , 2012, Analytical chemistry.

[8]  Marina Cretich,et al.  Biosticker : patterned microfluidic stickers for rapid integration with microarrays , 2011 .

[9]  Antonio Prado Moreno,et al.  Vlerick Leuven Gent Working Paper Series 2003/22 Starting Resource Configurations of Research-based Start-ups and the Interaction with Technology , 2022 .

[10]  G. Stemme,et al.  A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips. , 2010, Lab on a chip.

[11]  Bernard P. Puc,et al.  An integrated semiconductor device enabling non-optical genome sequencing , 2011, Nature.