The striatum in a putative cerebral network activated by verbal awareness in normals and in ADHD children

The aim of the present study was to evaluate the striatum's involvement in verbal awareness (semantic processing and supra‐modal attention) in normals and children with attention deficit hyperactivity disorder (ADHD). Our previous finding of striatal hypoperfusion in ADHD at rest, supports our prediction that the striatum will also show reduced activation in response to tasks requiring verbal awareness.

[1]  M. Posner,et al.  Localization of cognitive operations in the human brain. , 1988, Science.

[2]  G. Hynd,et al.  Attention Deficit- Hyperactivity Disorder and Asymmetry of the Caudate Nucleus , 1993, Journal of child neurology.

[3]  T. Hökfelt,et al.  Electron and fluorescence microscopical studies on the nucleus caudatus putamen of the rat after unilateral lesions of ascending nigro-neostriatal dopamine neurons. , 1969, Acta physiologica Scandinavica.

[4]  K. Heilman,et al.  Posterior neocortical systems subserving awareness and neglect. Neglect associated with superior temporal sulcus but not area 7 lesions. , 1994, Archives of neurology.

[5]  J. Rapoport,et al.  Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder. , 1994, The American journal of psychiatry.

[6]  E M Stokely,et al.  Normal Distribution of Regional Cerebral Blood Flow Measured by Dynamic Single-Photon Emission Tomography , 1986, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  Hanna Damasio,et al.  Neglect following damage to frontal lobe or basal ganglia , 1980, Neuropsychologia.

[8]  L. Henriksen,et al.  Focal cerebral dysfunction in developmental learning disabilities , 1990, The Lancet.

[9]  A Parving,et al.  Potential Language and Attentional Networks Revealed through Factor Analysis of rCBF Data Measured with SPECT , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[10]  L. Henriksen,et al.  Striatal dysfunction in attention deficit and hyperkinetic disorder. , 1989, Archives of neurology.

[11]  A M Graybiel,et al.  The basal ganglia and adaptive motor control. , 1994, Science.

[12]  J. Duncan The locus of interference in the perception of simultaneous stimuli. , 1980 .

[13]  H. Nauta Projections of the pallidal complex: An autoradiographic study in the cat , 1979, Neuroscience.

[14]  J. Cummings,et al.  Frontal-subcortical circuits and human behavior. , 1993, Journal of psychosomatic research.

[15]  M. Raichle,et al.  The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. , 1990, Proceedings of the National Academy of Sciences of the United States of America.