TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model
暂无分享,去创建一个
J. Shulman | S. Oldham | M. Feany | V. Khurana | M. L. Steinhilb | Yiran Lu
[1] Farid Ahmed,et al. Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[2] P. Hof,et al. Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms , 2005, The Journal of Neuroscience.
[3] R. Ravid,et al. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology , 2005, Journal of neurochemistry.
[4] Hyoung-Gon Lee,et al. Mitogen‐ and stress‐activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease , 2005, Journal of neuroscience research.
[5] Gloria Lee. Tau and src family tyrosine kinases. , 2005, Biochimica et biophysica acta.
[6] B. Winblad,et al. Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain , 2004, Neuroreport.
[7] M. Feany,et al. Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. , 2004, Human molecular genetics.
[8] T. P. Neufeld,et al. Role and regulation of starvation-induced autophagy in the Drosophila fat body. , 2004, Developmental cell.
[9] S. Benzer,et al. Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway , 2004, Current Biology.
[10] M. Bjornsti,et al. The tor pathway: a target for cancer therapy , 2004, Nature Reviews Cancer.
[11] B. Lu,et al. PAR-1 Kinase Plays an Initiator Role in a Temporally Ordered Phosphorylation Process that Confers Tau Toxicity in Drosophila , 2004, Cell.
[12] T. Gardner,et al. Insulin Promotes Rat Retinal Neuronal Cell Survival in a p70S6K-dependent Manner* , 2004, Journal of Biological Chemistry.
[13] Roland N. Emokpae,et al. Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage , 2004, Neuron.
[14] Esther B. E. Becker,et al. Cell cycle regulation of neuronal apoptosis in development and disease , 2004, Progress in Neurobiology.
[15] Susan Lindquist,et al. Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein , 2003, Science.
[16] J. Shulman,et al. Genetic modifiers of tauopathy in Drosophila. , 2003, Genetics.
[17] David S. Park,et al. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[18] Clemens R Scherzer,et al. Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. , 2003, Human molecular genetics.
[19] F. Tamanoi,et al. Drosophila Rheb GTPase is required for cell cycle progression and cell growth , 2003, Journal of Cell Science.
[20] H. Braak,et al. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. , 2003, The American journal of pathology.
[21] George Perry,et al. Increased p27, an essential component of cell cycle control, in Alzheimer's disease , 2003, Aging cell.
[22] S. Ackerman,et al. Oxidative stress, cell cycle, and neurodegeneration. , 2003, The Journal of clinical investigation.
[23] G. Perry,et al. Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? , 2003, Acta Neuropathologica.
[24] P. Hanawalt,et al. When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.
[25] E. Hafen,et al. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. , 2003, Trends in cell biology.
[26] Paul Greengard,et al. Pharmacological inhibitors of cyclin-dependent kinases. , 2002, Trends in pharmacological sciences.
[27] T. P. Neufeld,et al. Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila , 2002, Genesis.
[28] Tian Xu,et al. Akt regulates growth by directly phosphorylating Tsc2 , 2002, Nature Cell Biology.
[29] D. Geschwind,et al. Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila , 2002, Neuron.
[30] Maria K. Lehtinen,et al. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. , 2002, Molecular cell.
[31] M. Mattson,et al. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. , 2002, Physiological reviews.
[32] L. Greene,et al. Regulation of Neuronal Survival and Death by E2F-Dependent Gene Repression and Derepression , 2001, Neuron.
[33] Benjamin H. White,et al. A conditional tissue-specific transgene expression system using inducible GAL4 , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[34] I. Ferrer,et al. Phosphorylated c‐MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration , 2001, Neuropathology and applied neurobiology.
[35] Joshua M. Shulman,et al. Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles , 2001, Science.
[36] K. Herrup,et al. DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease , 2001, The Journal of Neuroscience.
[37] W. Chia,et al. cdc2 links the Drosophila cell cycle and asymmetric division machineries , 2001, Nature.
[38] M. Memo,et al. Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path? , 2001, Trends in Neurosciences.
[39] I. Vincent,et al. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases , 2000, Neurobiology of Aging.
[40] J. Ikeda,et al. Cyclin-dependent kinases as a therapeutic target for stroke. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[41] W. Bender,et al. A Drosophila model of Parkinson's disease , 2000, Nature.
[42] David S. Park,et al. Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis , 1999, The Journal of Neuroscience.
[43] E. Hafen,et al. Drosophila S6 kinase: a regulator of cell size. , 1999, Science.
[44] Ronald C. Petersen,et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 , 1998, Nature.
[45] Nancy M Bonini,et al. Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila , 1998, Cell.
[46] K. Herrup,et al. Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain , 1998, The Journal of Neuroscience.
[47] J. Tavaré,et al. Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival. , 1997, The Biochemical journal.
[48] M. Billingsley,et al. Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. , 1997, The Biochemical journal.
[49] I. Hariharan,et al. A Cyclin-Dependent Kinase Inhibitor, Dacapo, Is Necessary for Timely Exit from the Cell Cycle during Drosophila Embryogenesis , 1996, Cell.
[50] H. Orr,et al. In Vivo Viability of Postmitotic Purkinje Neurons Requires pRb Family Member Function , 1995, Molecular and Cellular Neuroscience.
[51] G. Thomas,et al. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb. , 2004, Novartis Foundation symposium.
[52] S. Lindquist,et al. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. , 2003, Science.
[53] J. Trojanowski,et al. Neurodegenerative tauopathies. , 2001, Annual review of neuroscience.