A reappraisal of caloric requirements in healthy women.

The caloric expenditure of 44 healthy, lean and obese women, 8 of whom were trained athletes, was measured by indirect calorimetry. Body composition was determined. Ages ranged from 18-65 yr and body weights from 43-143 kg. Stepwise, multiple-regression analysis was used to determine whether one or several variables best predicted the resting metabolic rate (RMR) of the women. The RMR and the thermic effect of food (TEF) were measured before and after the women consumed a mixed breakfast meal. The results showed that the currently available tables and regression equations overestimate the RMR of healthy women by 7-14%. Body weight was highly related to the RMR, and stepwise inclusions of various variables did not improve predictions of RMR. The slopes of the regression lines for nonathletes and athletes were significantly different. Regression equations for predicting RMR of women were developed: Nonathletes RMR = 795 + 7.18 kg WT; Athletes RMR = 50.4 + 21.1 kg WT. The range of RMR per kilogram body weight was wide for nonathletic, but narrow for athletic women. The metabolism of some lean and obese, nonathletic women was highly efficient, predisposing these women for developing and maintaining body fat. The TEFs were indistinguishable between nonathletic and athletic women, and formed a continuum from the lightest to the heaviest woman.

[1]  S. Welle,et al.  Stimulation of thermogenesis by carbohydrate overfeeding. Evidence against sympathetic nervous system mediation. , 1983, The Journal of clinical investigation.

[2]  S. Albert,et al.  Blood volume and extracellular fluid volume , 1971 .

[3]  D. Guernsey,et al.  The cell membrane sodium pump as a mechanism for increasing thermogenesis during cold acclimation in rats. , 1977, Science.

[4]  Joseph Berkson,et al.  Studies of the energy of metabolism of normal individuals: a standard for basal metabolism, with a nomogram for clinical application. , 1936 .

[5]  T. Mcmeekin,et al.  A NEW DIRECT NESSLERIZATION MICRO-KJELDAHL METHOD AND A MODIFICATION OF THE NESSLER-FOLIN REAGENT FOR AMMONIA , 1924 .

[6]  J. Halter,et al.  Reduced thermic effect of feeding in obesity: role of norepinephrine. , 1983, Metabolism: clinical and experimental.

[7]  J. Wang,et al.  Prediction of the resting metabolic rate in obese patients. , 1983, The American journal of clinical nutrition.

[8]  E. Nadel,et al.  Energy expenditure in obesity in fasting and postprandial state. , 1983, The American journal of physiology.

[9]  G. Leveille,et al.  Calorigenic response in obese and nonobese women. , 1976, The American journal of clinical nutrition.

[10]  E. Ravussin,et al.  Thermic effect of glucose in man. Obligatory and facultative thermogenesis. , 1984, The Journal of clinical investigation.

[11]  E Jéquier,et al.  Long-term measurements of energy expenditure in humans using a respiration chamber. , 1983, The American journal of clinical nutrition.

[12]  A S Jackson,et al.  Generalized equations for predicting body density of women. , 1980, Medicine and science in sports and exercise.

[13]  S. Heymsfield,et al.  Meal size and thermic response to food in male subjects as a function of maximum aerobic capacity. , 1984, Metabolism: clinical and experimental.

[14]  E. Jéquier,et al.  Glucose-induced Thermogenesis in Nondiabetic and Diabetic Obese Subjects , 1982, Diabetes.

[15]  B. Anand,et al.  ACTIVITY OF SINGLE NEURONS IN THE HYPOTHALAMIC FEEDING CENTERS: EFFECT OF GLUCOSE. , 1964, The American journal of physiology.

[16]  Charles Herbert Best,et al.  The physiological basis of medical practice , 1937 .

[17]  L. Landsberg,et al.  Catecholamines and the Sympathoadrenal System: The Regulation of Metabolism , 1979 .

[18]  A. T. Miller,et al.  Lean body mass as a metabolic reference standard. , 1953, Journal of applied physiology.

[19]  R. Grimble,et al.  The relationship between protein turnover and energy balance in lean and genetically obese (ob/ob)mice , 1979, British Journal of Nutrition.

[20]  D. Reid,et al.  Standards for the basal metabolism of normal people in Britain. , 1952, Lancet.

[21]  H. D. Bouman.  The Body Cell Mass and Its Supporting Environment , 1963 .

[22]  H. Krebs.  Some aspects of the regulation of fuel supply in omnivorous animals. , 1972, Advances in enzyme regulation.

[23]  I. Macdonald,et al.  Differences in dietary-induced thermogenesis with various carbohydrates in normal and overweight men. , 1982, The American journal of clinical nutrition.

[24]  J. Brozek,et al.  Body composition and basal metabolism in man: correlation analysis versus physiological approach. , 1955, Human biology.

[25]  P. Paul,et al.  Nature and quantity of fuels consumed in patients with alcoholic cirrhosis. , 1978, The Journal of clinical investigation.

[26]  M. Barrand,et al.  Postprandial thermogenesis in obesity. , 1981, Clinical science.

[27]  G. W. Snedecor.  Statistical Methods , 1964 .

[28]  Frederick Mosteller,et al.  Data Analysis and Regression , 1978 .

[29]  A. H. Norris,et al.  Longitudinal changes in basal metabolism in man. , 1978, Journal of applied physiology: respiratory, environmental and exercise physiology.

[30]  K. Acheson,et al.  Thermic effect of glucose in obese subjects studied by direct and indirect calorimetry , 1976, British Journal of Nutrition.

[31]  A. R. Behnke.  The relation of lean body weight to metabolism and some consequent systematizations. , 1954, Annals of the New York Academy of Sciences.

[32]  E. Jéquier,et al.  Thyroid hormones and thermogenesis: the metabolic cost of food and exercise. , 1984, Metabolism: clinical and experimental.

[33]  J. Himms-Hagen,et al.  Thermogenesis in brown adipose tissue as an energy buffer. Implications for obesity. , 1984, The New England journal of medicine.

[34]  J J Cunningham,et al.  A reanalysis of the factors influencing basal metabolic rate in normal adults. , 1980, The American journal of clinical nutrition.

[35]  K. Gey,et al.  Photometric "titration" of free fatty acids with the Technicon AutoAnalyzer. , 1966, Analytical biochemistry.

[36]  M. Kekki.  Microdetermination of amino nitrogen as copper complexes: a modification for plasma and urine. , 1959, Scandinavian journal of clinical and laboratory investigation.

[37]  G. Bray,et al.  Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. , 1979, Physiological reviews.

[38]  S. Welle,et al.  Normal thermic effect of glucose in obese women. , 1983, The American journal of clinical nutrition.

[39]  E Jéquier,et al.  Twenty-four-hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects. , 1982, The American journal of clinical nutrition.

[40]  A. Keys,et al.  Basal metabolism and age of adult man. , 1973, Metabolism: clinical and experimental.

[41]  E. Jéquier,et al.  Influence of beta-adrenergic blockade on glucose-induced thermogenesis in man. , 1983, The Journal of clinical investigation.

[42]  B. Crabtree,et al.  Substrate cycles in metabolic regulation and in heat generation. , 1976, Biochemical Society symposium.

[43]  A. Roza,et al.  The Harris Benedict equation reevaluated: resting energy requirements and the body cell mass. , 1984, The American journal of clinical nutrition.

[44]  E. Rosato,et al.  Resting Energy Expenditure in Morbid Obesity , 1983, Annals of surgery.

[45]  K. Acheson,et al.  Glycogen synthesis versus lipogenesis after a 500 gram carbohydrate meal in man. , 1982, Metabolism: clinical and experimental.

[46]  D. D. Bois,et al.  CLINICAL CALORIMETRY: TENTH PAPER A FORMULA TO ESTIMATE THE APPROXIMATE SURFACE AREA IF HEIGHT AND WEIGHT BE KNOWN , 1916 .

[47]  A. H. Norris,et al.  Effect of muscle mass decrease on age-related BMR changes. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[48]  A. Keys,et al.  DENSITOMETRIC ANALYSIS OF BODY COMPOSITION: REVISION OF SOME QUANTITATIVE ASSUMPTIONS * , 1963, Annals of the New York Academy of Sciences.

[49]  E P Cathcart,et al.  The composition and distribution of the fatty substances of the human subject , 1931, The Journal of physiology.

[50]  B. Gutin,et al.  Thermic effect of food at rest, during exercise, and after exercise in lean and obese men of similar body weight. , 1985, The Journal of clinical investigation.

[51]  Robertson Jd,et al.  Standards for the basal metabolism of normal people in Britain. , 1952 .

[52]  W. H. Marsh,et al.  AUTOMATED AND MANUAL DIRECT METHODS FOR THE DETERMINATION OF BLOOD UREA. , 1965, Clinical chemistry.

[53]  M. Foss,et al.  Restoration of Glucose Homeostasis in Insulin-dependent Diabetic Subjects: An Inducible Process , 1982, Diabetes.

[54]  W. M. Boothby,et al.  SUMMARY OF THE BASAL METABOLISM DATA ON 8,614 SUBJECTS WITH ESPECIAL REFERENCE TO THE NORMAL STANDARDS FOR THE ESTIMATION OF THE BASAL METABOLIC RATE , 1922 .

[55]  D. DuBois,et al.  A formula to estimate the approximate surface area if height and weight be known , 1989 .