Evaluation of Scanning Resolution on Retinal Nerve Fiber Layer Measurement Using Optical Coherence Tomography in Normal and Glaucomatous Eyes

To evaluate the effect of varying the scanning resolution of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) measurement on diagnostic sensitivity and functional correlation in glaucoma. Patients and Methods:314 eyes from 182 subjects including 107 normal eyes, 83 glaucoma suspect eyes, and 124 glaucoma eyes were included in this cross-sectional study. Standard automated perimetry and OCT measurement of RNFL thickness were performed. Each individual underwent two scanning protocols: (1) fast RNFL thickness (3.4) scan (with resolution of 256 scan points) and (2) RNFL thickness (3.4) scan (with resolution of 512 scan points). RNFL thickness was compared among the groups. Diagnostic sensitivity was evaluated with Receiver Operating Characteristic (ROC) Curve. Relationship between RNFL thickness and visual field mean deviation was examined using linear regression analysis. Results:Measured RNFL thickness using fast RNFL thickness (3.4) scan was significantly higher compared with RNFL thickness (3.4) scan in average, superior, nasal and inferior RNFL in all diagnostic groups. Comparing normal and glaucoma groups, RNFL thickness (3.4) scan produced the largest area under the ROC curve (0.912) based on average RNFL thickness. A stronger correlation between average RNFL and visual field mean deviation was found in RNFL thickness (3.4) scan (R = 0.75, R2 = 0.56). Conclusions:Higher resolution RNFL scan provides better diagnostic sensitivity in glaucoma detection and a stronger correlation with visual function.

[1]  Harald Sattmann,et al.  Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography. , 2003, Investigative ophthalmology & visual science.

[2]  L. Zangwill,et al.  Patterns of optic disk damage in patients with early focal visual field loss. , 1998, American journal of ophthalmology.

[3]  Makoto Nakamura,et al.  Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography. , 2003, American journal of ophthalmology.

[4]  E A Swanson,et al.  Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. , 1995, Archives of ophthalmology.

[5]  P. Carpineto,et al.  Reliability of nerve fiber layer thickness measurements using optical coherence tomography in normal and glaucomatous eyes. , 2003, Ophthalmology.

[6]  L. Zangwill,et al.  A comparison of optical coherence tomography and retinal nerve fiber layer photography for detection of nerve fiber layer damage in glaucoma. , 2000, Ophthalmology.

[7]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[8]  J. Fujimoto,et al.  Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography. , 2003, Archives of ophthalmology.

[9]  R Varma,et al.  Retinal nerve fiber layer thickness in normal human eyes. , 1996, Ophthalmology.

[10]  Anthony J Correnti,et al.  Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes. , 2003, Ophthalmology.

[11]  A. Sommer,et al.  Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. , 1991, Archives of ophthalmology.

[12]  W. Green,et al.  Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. , 1982, Archives of ophthalmology.

[13]  J. Fujimoto,et al.  Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography. , 1996, Ophthalmology.

[14]  R Ritch,et al.  Optical coherence tomography and scanning laser polarimetry in normal, ocular hypertensive, and glaucomatous eyes. , 2000, American journal of ophthalmology.

[15]  J. Caprioli,et al.  Optical coherence tomography to detect and manage retinal disease and glaucoma. , 2004, American journal of ophthalmology.

[16]  L. Zangwill,et al.  The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography. , 2000, Archives of ophthalmology.