Synthesis of a Novel Class of 3-(2'-Benzothiazolyl)-2,3-dihydroquinazolin-4(1H)-ones under Solvent-free and Catalyst-free Conditions

A solvent- and catalyst-free one-pot three-component condensation reaction approach was developed for the synthesis of a new class of 3-(2′-benzothiazolyl)-2,3-dihydroquinazolin-4(1H)-ones in relatively good yields.

[1]  A. Shaabani,et al.  A novel one-pot three-component reaction: synthesis of triheterocyclic 4H-pyrimido[2,1-b]benzazoles ring systems. , 2005, Bioorganic & medicinal chemistry letters.

[2]  M. Dabiri,et al.  Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using KAl(SO4)2·12H2O as a reusable catalyst in water and ethanol , 2005 .

[3]  M. Zolfigol,et al.  A Novel Method for the One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones , 2005 .

[4]  A. Shaabani,et al.  Ionic liquid promoted efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-ones , 2005 .

[5]  Yuyang Jiang,et al.  Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains. , 2005, Bioorganic & medicinal chemistry letters.

[6]  Libing Yu,et al.  Microwave-assisted one-pot synthesis of 2,3-disubstituted 3 H-quinazolin-4-ones , 2005 .

[7]  A. Shaabani,et al.  A novel pseudo four-component reaction: unexpected formation of densely functionalized pyrroles , 2004 .

[8]  W. Voelter,et al.  A Novel Method for the Synthesis of 4(3H)‐Quinazolinones. , 2004 .

[9]  A. Shaabani,et al.  Microwave-assisted efficient synthesis of spiro-fused heterocycles under solvent-free conditions , 2004 .

[10]  A. Shaabani,et al.  A reexamination of Biginelli-like multicomponent condensation reaction: One-pot regioselective synthesis of spiro heterobicyclic rings , 2004, Molecular Diversity.

[11]  D. Shi,et al.  Synthesis of quinazolin-4(3H)-ones and 1,2-dihydroquinazolin-4(3H)-ones with the aid of a low-valent titanium reagent , 2003 .

[12]  A. Shaabani,et al.  Ammonium chloride-catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions , 2003 .

[13]  A. Shaabani,et al.  One-pot three component condensation reaction in water: an efficient and improved procedure for the synthesis of furo[2,3-d]pyrimidine-2,4(1H, 3H)-diones , 2002 .

[14]  C. Kappe,et al.  High-speed combinatorial synthesis utilizing microwave irradiation. , 2002, Current opinion in chemical biology.

[15]  Gareth W. V. Cave,et al.  Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility. , 2001, Chemical communications.

[16]  A. Shaabani,et al.  New and efficient synthesis of dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates , 2001 .

[17]  A. Shaabani,et al.  REACTION OF 2-AMINOBENZIMIDAZOL: A SIMPLE ONE-POT SYNTHESIS OF STABLE HETEROCYCLIC PHOSPHORUS YLIDES , 2001 .

[18]  I. Ugi,et al.  Multicomponent Reactions with Isocyanides. , 2000, Angewandte Chemie.

[19]  N. Urdaneta,et al.  The Synthesis of Substituted 2-Aryl 4(3H)-Quinazolinones using Nahso3/Dma. Steric Effect upon the Cyclisation-Dehydrogenation Step , 2000 .

[20]  S Diamond,et al.  Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors. , 2000, Journal of medicinal chemistry.

[21]  K. Tanaka,et al.  Solvent-free organic synthesis. , 2000, Chemical reviews.

[22]  P. D. Cook,et al.  Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents. , 1999, Journal of medicinal chemistry.

[23]  M. Ueno,et al.  Catalytic asymmetric synthesis of febrifugine and isofebrifugine , 1999 .

[24]  J. Metzger Solvent-Free Organic Syntheses. , 1998, Angewandte Chemie.

[25]  N. Liverton,et al.  Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists. , 1998, Bioorganic & medicinal chemistry letters.

[26]  Jiang-Ping Wu,et al.  Synthesis and anticonvulsant activity of the (+)- and (−)-enantiomers of 1,2,3,4-tetrahydro-5-(2-phosphonoethyl)-3-isoquinolinecarboxylic acid, a competitive NMDA antagonist , 1993 .

[27]  R. Soll,et al.  The synthesis and structural characterization of way-120,491; a novel potassium channel activator , 1991 .

[28]  J. F. Wolfe,et al.  Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones. , 1990, Journal of medicinal chemistry.

[29]  S. Sharma,et al.  Synthesis of 3-Oxa- and 3-Aza-1-dethiacepham Analogs , 1990 .

[30]  B. Loev,et al.  Amidines. 5. Synthesis of pyrrolo (2,3-b)isoquinoline, imidazo(1,2-b)isoquinoline, pyrrolo(2,1-b)quinazoline, and 1,3 1,3-thiazine(2,3-b)quinazoline derivatives and related heterocycles as potential antihypertensive agents. , 1973, Journal of medicinal chemistry.

[31]  D. Delong,et al.  Heterocyclic substituted ureas. I. Immunosuppression and virus inhibition by benzimidazoleureas. , 1969, Journal of medicinal chemistry.

[32]  G. J. Sutherland,et al.  Reactions of anthranilamide and o-aminoacetophenone with benzil and benzoin , 1969 .

[33]  B. R. Baker,et al.  AN ANTIMALARIAL ALKALOID FROM HYDRANGEA. XVIII. DERIVATIVES OF 4-PYRIMIDONE , 1953 .