Modelling and optimal state-delay control in microbial batch process

Abstract In this paper, we consider optimal control problem involving a time-varying state-delay system arising in 1,3-propanediol microbial batch process. The dynamic system in this problem includes unknown time-varying delay function and unknown kinetic parameters. To optimally determine the unknown delay function and unknown kinetic parameters in the system, the weighted least-squares error between the computed values and experimental data is minimized subject to path constraints. By parameterizing the delay function with piecewise quadratic basis functions, the optimal state-delay control problem is approximated by a sequence of parameter optimization problems. Furthermore, an exact penalty method is utilized to transform these parameter optimization problems into the ones only with box constraints. On this basis, a modified differential evolution algorithm is developed to solve the resulting optimization problems. Finally, numerical results are presented to verify the effectiveness of the developed solution approach.

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