Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms

[1]  H. Sei,et al.  Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults , 2006, Behavioural Brain Research.

[2]  A. Itai,et al.  A Novel IκB Kinase-β Inhibitor Ameliorates Bleomycin-induced Pulmonary Fibrosis in Mice , 2006 .

[3]  R. Leighty,et al.  Lifelong immunization with human β-amyloid (1–42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging , 2005, Neuroscience.

[4]  R. Ravid,et al.  Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease , 2005, Neuroreport.

[5]  B. Kaang,et al.  An Aplysia Type 4 Phosphodiesterase Homolog Localizes at the Presynaptic Terminals of Aplysia Neuron and Regulates Synaptic Facilitation , 2005, The Journal of Neuroscience.

[6]  C. Cotman.  The Role of Neurotrophins in Brain Aging: A Perspective in Honor of Regino Perez-Polo , 2005, Neurochemical Research.

[7]  D. Borchelt,et al.  Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.

[8]  C. Bagni.  Faculty Opinions recommendation of Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. , 2005 .

[9]  Ilana S. Hairston,et al.  Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice , 2005, Cell.

[10]  David A. Snowdon,et al.  Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study , 2005, Neurobiology of Aging.

[11]  F. Crews,et al.  TNFα potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NFκB inhibition , 2005, Brain Research.

[12]  W. Gan,et al.  Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2 , 2005, The Journal of Neuroscience.

[13]  G. Laviola,et al.  Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer’s disease , 2005, Behavioural Brain Research.

[14]  O. Vitolo,et al.  Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. , 2004, The Journal of clinical investigation.

[15]  Mark Mayford,et al.  Nuclear Calcium/Calmodulin Regulates Memory Consolidation , 2004, The Journal of Neuroscience.

[16]  J. Trojanowski,et al.  Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. , 2004, The American journal of pathology.

[17]  S. Paul,et al.  Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation , 2004, Neurobiology of Aging.

[18]  C. DeCarli,et al.  Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis , 2004, The Journal of Neuroscience.

[19]  S. Sajikumar,et al.  The Type IV-Specific Phosphodiesterase Inhibitor Rolipram and Its Effect on Hippocampal Long-Term Potentiation and Synaptic Tagging , 2004, The Journal of Neuroscience.

[20]  S. Paul,et al.  Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer’s transgenic mouse lines differing in Aβ deposition , 2004, Behavioural Brain Research.

[21]  H. Potter,et al.  Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable &bgr;-amyloid deposition , 2004, Neuroreport.

[22]  J. O'Donnell,et al.  Inhibition of the Phosphodiesterase 4 (PDE4) Enzyme Reverses Memory Deficits Produced by Infusion of the MEK Inhibitor U0126 into the CA1 Subregion of the Rat Hippocampus , 2004, Neuropsychopharmacology.

[23]  S. Czaja,et al.  Cognitive rehabilitation of mildly impaired Alzheimer disease patients on cholinesterase inhibitors. , 2004, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[24]  M. Hutton,et al.  Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's Disease: linkage of poorer cognitive performance to tau pathology in forebrain , 2004, Brain Research.

[25]  E. Castrén,et al.  Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB–PLCγ pathway, reduced anxiety, and facilitated learning , 2004, Molecular and Cellular Neuroscience.

[26]  D. Borchelt,et al.  Environmental Enrichment Exacerbates Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease , 2003, Journal of neuropathology and experimental neurology.

[27]  W. Honer.  Pathology of presynaptic proteins in Alzheimer’s disease: more than simple loss of terminals , 2003, Neurobiology of Aging.

[28]  D. Dickstein,et al.  Blood—Brain Barrier Permeability Precedes Senile Plaque Formation in an Alzheimer Disease Model , 2003 .

[29]  T. Tully,et al.  A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Karyn M. Frick,et al.  Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice , 2003, Neurobiology of Aging.

[31]  M. King,et al.  Environmental enrichment: effects on stereotyped behavior and dendritic morphology. , 2003, Developmental psychobiology.

[32]  P. Coleman,et al.  Defects in expression of genes related to synaptic vesicle traffickingin frontal cortex of Alzheimer’s disease , 2003, Neurobiology of Disease.

[33]  D. Appelt,et al.  Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells. , 2002, FEMS microbiology letters.

[34]  S. Paul,et al.  Apolipoprotein E alters the processing of the β-amyloid precursor protein in APPV717F transgenic mice , 2002, Brain Research.

[35]  Jeffrey A. Johnson,et al.  Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways , 2002, The Journal of Neuroscience.

[36]  J. Schneider,et al.  Participation in cognitively stimulating activities and risk of incident Alzheimer disease. , 2002, JAMA.

[37]  P. Clarke,et al.  Dual role of the NF-κB transcription factor in the death of immature neurons , 2001, Neuroscience.

[38]  R. Egleton,et al.  Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier , 2001, Trends in Neurosciences.

[39]  H. Potter,et al.  The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation , 2001, Neurobiology of Aging.

[40]  D. Diamond,et al.  Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. , 2001, DNA and cell biology.

[41]  R. Currie,et al.  Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment: implications for molecular plasticity. , 2001, Brain research. Molecular brain research.

[42]  Alcino J. Silva,et al.  α-CaMKII-dependent plasticity in the cortex is required for permanent memory , 2001, Nature.

[43]  D. Diamond,et al.  Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice , 2001, Neurobiology of Aging.

[44]  D. Diamond,et al.  Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes , 2001, Brain Research.

[45]  D. Lockhart,et al.  Effects of environmental enrichment on gene expression in the brain. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. Warrington,et al.  Comparison of human adult and fetal expression and identification of 535 housekeeping/maintenance genes. , 2000, Physiological genomics.

[47]  T. Yamauchi,et al.  Transthyretin binds amyloid β peptides, Aβ1–42 and Aβ1–40 to form complex in the autopsied human kidney – possible role of transthyretin for Aβ sequestration , 2000, Neuroscience Letters.

[48]  M. Dragunow,et al.  Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective , 1999, Nature Medicine.

[49]  C. Masters,et al.  Recombinant human amyloid precursor‐like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth , 1999, FEBS letters.

[50]  E. Kandel,et al.  Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[51]  D. Christmann,et al.  Cerebrospinal fluid transthyretin: aging and late onset Alzheimer’s disease , 1997, Journal of neurology, neurosurgery, and psychiatry.

[52]  H. Yamaguchi,et al.  Amyloid β protein and transthyretin, sequestrating protein colocalize in normal human kidney , 1997, Neuroscience Letters.

[53]  J. Hardy,et al.  Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1 , 1996, Nature.

[54]  Alcino J. Silva,et al.  Requirement for α-CaMKII in Experience-Dependent Plasticity of the Barrel Cortex , 1996, Science.

[55]  D R Wekstein,et al.  Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. , 1996, JAMA.

[56]  W. Greenough,et al.  Differential Rearing Alters Spine Density on Medium-Sized Spiny Neurons in the Rat Corpus Striatum: Evidence for Association of Morphological Plasticity with Early Response Gene Expression , 1995, Neurobiology of Learning and Memory.

[57]  M. Dragunow,et al.  Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. , 1995, Pharmacological reviews.

[58]  L. Mucke,et al.  Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein , 1995, Nature.

[59]  W. Strittmatter,et al.  Transthyretin sequesters amyloid beta protein and prevents amyloid formation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[60]  R. Mayeux,et al.  Influence of education and occupation on the incidence of Alzheimer's disease. , 1994, JAMA.

[61]  Alcino J. Silva,et al.  Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. , 1992, Science.

[62]  J. Eberwine,et al.  Amplified RNA synthesized from limited quantities of heterogeneous cDNA. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[63]  R. Tsien,et al.  Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. , 1989, Science.

[64]  P. S. St George-Hyslop,et al.  Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. , 1987, Science.

[65]  M R Rosenzweig,et al.  Effects of differential experience on dendritic spine counts in rat cerebral cortex. , 1973, Journal of comparative and physiological psychology.

[66]  Sholl Da.  Dendritic organization in the neurons of the visual and motor cortices of the cat. , 1953 .

[67]  F. Crews,et al.  TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition. , 2005, Brain research.

[68]  M. Merville,et al.  Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation , 2005 .

[69]  Vladimir V. Frolkis,et al.  Neurobiology of Aging , 2019, Psychobiology of Behaviour.

[70]  S. Paul,et al.  Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. , 2004, Journal of Alzheimer's Disease.

[71]  J. Trojanowski,et al.  Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. , 2004, The American journal of pathology.

[72]  A. Vorbrodt,et al.  Immunogold localization of tight junctional proteins in normal and osmotically-affected rat blood-brain barrier , 2004, Journal of Molecular Histology.

[73]  P. Clarke,et al.  Dual role of the NF-kappaB transcription factor in the death of immature neurons. , 2001, Neuroscience.

[74]  K. Fox,et al.  The role of alpha-CaMKII autophosphorylation in neocortical experience-dependent plasticity. , 2000, Nature neuroscience.

[75]  T. Yamauchi,et al.  Transthyretin binds amyloid beta peptides, Abeta1-42 and Abeta1-40 to form complex in the autopsied human kidney - possible role of transthyretin for abeta sequestration. , 2000, Neuroscience letters.

[76]  M. Escobar,et al.  Synaptogenesis of mossy fibers induced by spatial water maze overtraining , 1999, Hippocampus.

[77]  K. Fox,et al.  Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex. , 1996, Science.

[78]  C F Stevens,et al.  Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. , 1992, Cold Spring Harbor symposia on quantitative biology.

[79]  D. Sholl.  Dendritic organization in the neurons of the visual and motor cortices of the cat. , 1953, Journal of anatomy.