Targeting oral tumor microenvironment for effective therapy

[1]  F. Calvo,et al.  Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment. , 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[2]  M. Tsoumakidou The advent of immune stimulating CAFs in cancer , 2023, Nature Reviews Cancer.

[3]  M. Najafi,et al.  Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression , 2023, Clinical and experimental pharmacology & physiology.

[4]  M. Najafi,et al.  Cardiac Injury Following Chemo/Radiation Therapy: An Updated Review on Mechanisms and Therapeutic Approaches. , 2023, Current radiopharmaceuticals.

[5]  Zhenqiang Sun,et al.  Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers , 2023, Molecular Cancer.

[6]  L. Mao,et al.  CD103 blockade impair anti-CTLA-4 immunotherapy in oral cancer. , 2023, Oral oncology.

[7]  M. Najafi,et al.  Tumor-associated macrophages (TAMs) in cancer resistance; modulation by natural products. , 2023, Current topics in medicinal chemistry.

[8]  Xiaoyi Wang,et al.  Pharmaceutical targeting Th2-mediated immunity enhances immunotherapy response in breast cancer , 2022, Journal of translational medicine.

[9]  Alejandra G Martinez-Perez,et al.  The Emerging Role of NK Cells in Immune Checkpoint Blockade , 2022, Cancers.

[10]  Lan Wu,et al.  Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2 , 2022, Stem cells international.

[11]  Hao Cui,et al.  STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma , 2022, Cancer Immunology, Immunotherapy.

[12]  J. Jakubowicz-Gil,et al.  The Dual Blockade of the TIGIT and PD-1/PD-L1 Pathway as a New Hope for Ovarian Cancer Patients , 2022, Cancers.

[13]  N. An,et al.  Interleukin‐23 receptor defines T helper 1‐like regulatory T cells in oral squamous cell carcinoma , 2022, Immunity, inflammation and disease.

[14]  B. Khademi,et al.  Regulatory and effector T cell subsets in tumor-draining lymph nodes of patients with squamous cell carcinoma of head and neck , 2022, BMC Immunology.

[15]  Tetsu Takahashi,et al.  Myeloid‐derived suppressor cells and plasmacytoid dendritic cells are associated with oncogenesis of oral squamous cell carcinoma , 2022, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[16]  G. Kayser,et al.  Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy , 2022, Radiation Oncology.

[17]  N. D’Silva,et al.  Influence of tumor cell-derived TGF-β on macrophage phenotype and macrophage-mediated tumor cell invasion. , 2022, The international journal of biochemistry & cell biology.

[18]  C. Haglund,et al.  Tertiary lymphoid structures associate with improved survival in early oral tongue cancer , 2022, BMC Cancer.

[19]  M. Najafi,et al.  Resveratrol in cancer therapy; from stimulation of genomic stability to adjuvant cancer therapy; A comprehensive review. , 2022, Current topics in medicinal chemistry.

[20]  Zhaoyu Lin,et al.  Tumor-Associated Macrophages Promote Metastasis of Oral Squamous Cell Carcinoma via CCL13 Regulated by Stress Granule , 2022, Cancers.

[21]  A. Jalil,et al.  Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms , 2022, Clinical and experimental pharmacology & physiology.

[22]  Lei Cheng,et al.  Cancer-associated fibroblast-like fibroblasts in vocal fold leukoplakia suppress CD8+T cell functions by inducing IL-6 autocrine loop and interacting with Th17 cells. , 2022, Cancer letters.

[23]  M. Nasser,et al.  To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3. , 2022, Biochimica et biophysica acta. Reviews on cancer.

[24]  Y. Liu,et al.  The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer , 2022, Evidence-based complementary and alternative medicine : eCAM.

[25]  M. Najafi,et al.  Effect of Nano-Curcumin on Radiotherapy-Induced Skin Reaction in Breast Cancer Patients: A Randomized, Triple-Blind, Placebo-Controlled Trial. , 2022, Current radiopharmaceuticals.

[26]  Chi Thi Kim Nguyen,et al.  Comprehensive Integrated Single-Cell Whole Transcriptome Analysis Revealed the p-EMT Tumor Cells—CAFs Communication in Oral Squamous Cell Carcinoma , 2022, International journal of molecular sciences.

[27]  M. Najafi,et al.  Boosting anti-tumour immunity using adjuvant apigenin. , 2022, Anti-cancer agents in medicinal chemistry.

[28]  S. Sukegawa,et al.  Crosstalk between cancer and different cancer stroma subtypes promotes the infiltration of tumor-associated macrophages into the tumor microenvironment of oral squamous cell carcinoma , 2022, International journal of oncology.

[29]  Xia Li,et al.  Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway , 2022, Journal of experimental & clinical cancer research : CR.

[30]  Katherine Tooley,et al.  Spatial determinants of CD8+ T cell differentiation in cancer. , 2022, Trends in cancer.

[31]  C. Sautès-Fridman,et al.  B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome , 2022, Nature Reviews Clinical Oncology.

[32]  M. Kesting,et al.  Beyond PD-L1—Identification of Further Potential Therapeutic Targets in Oral Cancer , 2022, Cancers.

[33]  M. Ashrafizadeh,et al.  Imperatorin attenuates proliferation of MCF-7 Cells in combination with Radiotherapy or Hyperthermia. , 2022, Current radiopharmaceuticals.

[34]  G. Shi,et al.  Functional Diversities of Regulatory T Cells in the Context of Cancer Immunotherapy , 2022, Frontiers in Immunology.

[35]  G. Sethi,et al.  Nuclear receptors in oral cancer-emerging players in tumorigenesis. , 2022, Cancer letters.

[36]  S. Muller,et al.  Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue , 2022, Head and Neck Pathology.

[37]  J. Kyula,et al.  Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade , 2022, Journal for ImmunoTherapy of Cancer.

[38]  S. Zhu,et al.  GSDME Is Related to Prognosis and Response to Chemotherapy in Oral Cancer , 2022, Journal of dental research.

[39]  Kai Yang,et al.  The PER1/HIF-1alpha negative feedback loop promotes ferroptosis and inhibits tumor progression in oral squamous cell carcinoma , 2022, Translational oncology.

[40]  M. Najafi,et al.  The interactions of paclitaxel with tumour microenvironment. , 2022, International immunopharmacology.

[41]  Fei-Ting Hsu,et al.  Regorafenib enhances antitumor immune efficacy of anti-PD-L1 immunotherapy on oral squamous cell carcinoma. , 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[42]  M. Xiao,et al.  M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop , 2022, Journal of Experimental & Clinical Cancer Research.

[43]  Fan Luo,et al.  HIF-1α inhibition promotes the efficacy of immune checkpoint blockade in the treatment of non-small cell lung cancer. , 2022, Cancer letters.

[44]  M. Ashrafizadeh,et al.  Role of Tumor Microenvironment in Cancer Stem Cells Resistance to Radiotherapy. , 2021, Current cancer drug targets.

[45]  Yantong Lu,et al.  Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy , 2021, Frontiers in Immunology.

[46]  S. Tomida,et al.  Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment , 2021, JCI insight.

[47]  O. Kujan,et al.  PD-1/PD-L1, Treg-related proteins, and tumour-infiltrating lymphocytes are associated with the development of oral squamous cell carcinoma , 2021, Pathology.

[48]  M. Haddadi,et al.  Clinical and diagnostic potential of regulatory T cell markers: From bench to bedside. , 2021, Transplant immunology.

[49]  Changming Tan,et al.  Cardiac inflammation and fibrosis following chemo/radiation therapy: mechanisms and therapeutic agents , 2021, Inflammopharmacology.

[50]  Å. Helland,et al.  The Immune Landscape of Human Primary Lung Tumors Is Th2 Skewed , 2021, Frontiers in Immunology.

[51]  Xia Li,et al.  Repression of CRNDE enhances the anti‐tumour activity of CD8 + T cells against oral squamous cell carcinoma through regulating miR‐545‐5p and TIM‐3 , 2021, Journal of cellular and molecular medicine.

[52]  Qingming Ma,et al.  Normalization of the tumor microvasculature based on targeting and modulation of the tumor microenvironment. , 2021, Nanoscale.

[53]  M. Najafi,et al.  Targeting of the tumor immune microenvironment by metformin , 2021, Journal of Cell Communication and Signaling.

[54]  T. Blankenstein,et al.  The role of CD4 T cells in rejection of solid tumors , 2021, Current opinion in immunology.

[55]  C. R. Leemans,et al.  NK Cell-Dependent Antibody-Mediated Immunotherapy Is Improved In Vitro and In Vivo When Combined with Agonists for Toll-like Receptor 2 in Head and Neck Cancer Models , 2021, International journal of molecular sciences.

[56]  Zhentao Yang,et al.  Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma , 2021, Cell reports. Medicine.

[57]  W. Liang,et al.  The association between CD8+ tumor-infiltrating lymphocytes and the clinical outcome of cancer immunotherapy: A systematic review and meta-analysis , 2021, EClinicalMedicine.

[58]  S. Karam,et al.  FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC , 2021, Clinical Cancer Research.

[59]  Weiwen Zhu,et al.  Cancer-associated fibroblasts promote oral squamous cell carcinoma progression through LOX-mediated matrix stiffness , 2021, Journal of translational medicine.

[60]  J. Lawler,et al.  Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake , 2021, Cancers.

[61]  A. Zhavoronkov,et al.  Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma , 2021, Cell reports. Medicine.

[62]  F. Shi,et al.  Combined effects of hyperthermia and chemotherapy on the regulate autophagy of oral squamous cell carcinoma cells under a hypoxic microenvironment , 2021, Cell death discovery.

[63]  M. Moriyama,et al.  Oral Squamous Cell Carcinoma Contributes to Differentiation of Monocyte-Derived Tumor-Associated Macrophages via PAI-1 and IL-8 Production , 2021, International journal of molecular sciences.

[64]  M. Najafi,et al.  Targeting of the tumor microenvironment by curcumin , 2021, BioFactors.

[65]  Zhijun Sun,et al.  TIGIT/CD155 blockade enhances anti-PD-L1 therapy in head and neck squamous cell carcinoma by targeting myeloid-derived suppressor cells. , 2021, Oral oncology.

[66]  R. Ueda,et al.  Tumor‐infiltrating FoxP3+ T cells are associated with poor prognosis in oral squamous cell carcinoma , 2021, Clinical and experimental dental research.

[67]  Wei Yu,et al.  CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment , 2021, Frontiers in Oncology.

[68]  T. Tsuzuki,et al.  Improving function of cytotoxic T‐lymphocytes by transforming growth factor‐β inhibitor in oral squamous cell carcinoma , 2021, Cancer science.

[69]  M. Najafi,et al.  Modulation of the tumor microenvironment (TME) by melatonin. , 2021, European journal of pharmacology.

[70]  S. Madhunapantula,et al.  The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status. , 2021, Current medicinal chemistry.

[71]  Z. Qin,et al.  Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming , 2021, Theranostics.

[72]  P. Timpson,et al.  Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance , 2021, Cancers.

[73]  Y. Kudo,et al.  The Soluble Factor from Oral Cancer Cell Lines Inhibits Interferon-γ Production by OK-432 via the CD40/CD40 Ligand Pathway , 2021, Cancers.

[74]  M. Najafi,et al.  Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells. , 2021, International immunopharmacology.

[75]  L. Ding,et al.  CD38 Multi-Functionality in Oral Squamous Cell Carcinoma: Prognostic Implications, Immune Balance, and Immune Checkpoint , 2021, Frontiers in Oncology.

[76]  Yunpeng Bai,et al.  Overview of Evidence-Based Chemotherapy for Oral Cancer: Focus on Drug Resistance Related to the Epithelial-Mesenchymal Transition , 2021, Biomolecules.

[77]  S. Fan,et al.  Single-cell profiling of tumor-infiltrating TCF1/TCF7+ T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer. , 2021, Oral oncology.

[78]  F. Hodi,et al.  Phase I/Ib Clinical Trial of Sabatolimab, an Anti–TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti–PD-1 Antibody, in Advanced Solid Tumors , 2021, Clinical Cancer Research.

[79]  J. Santibañez,et al.  Transforming growth factor‐beta1 and myeloid‐derived suppressor cells: A cancerous partnership , 2021, Developmental dynamics : an official publication of the American Association of Anatomists.

[80]  D. G. Osborne,et al.  Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis , 2021, Journal for ImmunoTherapy of Cancer.

[81]  Jie Cheng,et al.  Prognostic role of CD11b+ myeloid-derived suppressor cells in oral squamous cell carcinoma , 2021, Archives of medical science : AMS.

[82]  Hongmei Zhou,et al.  Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway , 2021, International journal of oral science.

[83]  So Yeong Lee,et al.  Kv3 channels contribute to cancer cell migration via vimentin regulation. , 2021, Biochemical and biophysical research communications.

[84]  Yanhong Ji,et al.  CircKRT1 drives tumor progression and immune evasion in oral squamous cell carcinoma by sponging miR‐495‐3p to regulate PDL1 expression , 2021, Cell biology international.

[85]  Shengwei Han,et al.  Cancer‐associated fibroblasts secrete hypoxia‐induced serglycin to promote head and neck squamous cell carcinoma tumor cell growth in vitro and in vivo by activating the Wnt/β-catenin pathway , 2021, Cellular Oncology.

[86]  R. Banerjee,et al.  The prospects of Nanotherapeutic approaches for targeting Tumor-Associated Macrophages in oral cancer. , 2021, Nanomedicine : nanotechnology, biology, and medicine.

[87]  T. Cox The matrix in cancer , 2021, Nature Reviews Cancer.

[88]  Hongmei Zhou,et al.  Ionizing radiation-induced 'zombie' carcinoma-associated fibroblasts with suppressed pro-radioresistance on OSCC cells. , 2021, Oral diseases.

[89]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[90]  M. Masařík,et al.  Sensitivity to Cisplatin in Head and Neck Cancer Cells Is Significantly Affected by Patient-Derived Cancer-Associated Fibroblasts , 2021, International journal of molecular sciences.

[91]  M. Teh,et al.  Major Molecular Signaling Pathways in Oral Cancer Associated With Therapeutic Resistance , 2021, Frontiers in Oral Health.

[92]  P. Lequerica-Fernández,et al.  Tumor-Infiltrating CD20+ B Lymphocytes: Significance and Prognostic Implications in Oral Cancer Microenvironment , 2021, Cancers.

[93]  B. Seliger,et al.  Tumor Microenvironment, HLA Class I and APM Expression in HPV-Negative Oral Squamous Cell Carcinoma , 2021, Cancers.

[94]  K. Ahn,et al.  Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis. , 2021, Life sciences.

[95]  A. Egloff,et al.  Integrating CD4+ T cell help for therapeutic cancer vaccination in a preclinical head and neck cancer model , 2021, Oncoimmunology.

[96]  Xin Xu,et al.  YKT6, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltration , 2021, Oncoimmunology.

[97]  V. Radhakrishnan,et al.  Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers , 2020, Frontiers in Oral Health.

[98]  S. Bondi,et al.  Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis , 2020, International journal of environmental research and public health.

[99]  J. Cho,et al.  Prognostic impact of regulatory T cell in head and neck squamous cell carcinoma: A systematic review and meta-analysis. , 2020, Oral oncology.

[100]  Juan Fang,et al.  Dysfunctional role of elevated TIGIT expression on T cells in oral squmaous cell carcinoma patients. , 2020, Oral diseases.

[101]  M. Ashrafizadeh,et al.  Resveratrol as an Enhancer of Apoptosis in Cancer: A Mechanistic Review. , 2020, Anti-cancer agents in medicinal chemistry.

[102]  J. Gu,et al.  Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer , 2020, Journal for ImmunoTherapy of Cancer.

[103]  Juan Fang,et al.  Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma , 2020, International journal of oral science.

[104]  Muh-Hwa Yang,et al.  Fibroblast Promotes Head and Neck Squamous Cell Carcinoma Cell Invasion through Mechanical Barriers in 3D Collagen Microenvironments. , 2020, ACS applied bio materials.

[105]  S. Gill,et al.  Enhancing the efficacy of immunotherapy using radiotherapy , 2020, Clinical & translational immunology.

[106]  N. Kitkumthorn,et al.  Evaluation of lymphocyte apoptosis in patients with oral cancer , 2020, Journal of applied oral science : revista FOB.

[107]  A. Santarelli,et al.  Prognostic Relevance of Macrophage Phenotypes in High-grade Oral Tongue Squamous Cell Carcinomas. , 2020, Applied immunohistochemistry & molecular morphology : AIMM.

[108]  I. Grosse,et al.  Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma , 2020, International journal of molecular sciences.

[109]  H. Hiratsuka,et al.  Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma , 2020, PloS one.

[110]  Z. Shao,et al.  Natural killer cells in cancer biology and therapy , 2020, Molecular Cancer.

[111]  Y. Tao,et al.  Exosomes: key players in cancer and potential therapeutic strategy , 2020, Signal Transduction and Targeted Therapy.

[112]  M. Ashrafizadeh,et al.  PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation , 2020, Biomedicines.

[113]  Gang Wu,et al.  USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer , 2020, Theranostics.

[114]  Gan Huang,et al.  ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer , 2020, Oxidative medicine and cellular longevity.

[115]  M. Ashrafizadeh,et al.  The interactions and communications in tumor resistance to radiotherapy: Therapy perspectives. , 2020, International immunopharmacology.

[116]  M. Ashrafizadeh,et al.  Damage-associated molecular patterns in tumor radiotherapy. , 2020, International immunopharmacology.

[117]  R. Mohammadinejad,et al.  MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy , 2020, Biomolecules.

[118]  Joseph Cursons,et al.  The cancer–natural killer cell immunity cycle , 2020, Nature Reviews Cancer.

[119]  A. Kimoto,et al.  Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study , 2020, BMC Cancer.

[120]  M. Ashrafizadeh,et al.  Abscopal effect in radioimmunotherapy. , 2020, International immunopharmacology.

[121]  M. Ashrafizadeh,et al.  PD-1/PD-L1 axis regulation in cancer therapy: The role of long non-coding RNAs and microRNAs. , 2020, Life sciences.

[122]  Hyesun Hyun,et al.  Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment , 2020, Acta Pharmacologica Sinica.

[123]  Y. Takai,et al.  YC-1 sensitizes the antitumor effects of boron neutron capture therapy in hypoxic tumor cells , 2020, Journal of radiation research.

[124]  J. Schlom,et al.  PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations , 2020, Journal for immunotherapy of cancer.

[125]  K. Hirakawa,et al.  Immunological potential of tertiary lymphoid structures surrounding the primary tumor in gastric cancer , 2020, International journal of oncology.

[126]  D. Chaukar,et al.  Hypoxia regulates the differentiation and anti‐tumor effector functions of γδT cells in oral cancer , 2020, Clinical and experimental immunology.

[127]  Yan Chen,et al.  Emerging nano drug delivery systems targeting cancer-associated fibroblasts for improved anti-tumor effect and tumor drug penetration. , 2020, Molecular pharmaceutics.

[128]  A. Psyrri,et al.  Nivolumab-related lichen planus of the lip in a patient with head and neck cancer. , 2020, Oral oncology.

[129]  K. Okoń,et al.  Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders , 2020, Journal of clinical medicine.

[130]  Wenhuan Bu,et al.  Long non-coding RNA TIRY promotes tumor metastasis by enhancing epithelial-to-mesenchymal transition in oral cancer , 2020, Experimental biology and medicine.

[131]  A. D'cruz,et al.  Myeloid-derived suppressor cells impede T cell functionality and promote Th17 differentiation in oral squamous cell carcinoma , 2020, Cancer Immunology, Immunotherapy.

[132]  Xikun Zhou,et al.  Tumor-Associated Macrophages: Recent Insights and Therapies , 2020, Frontiers in Oncology.

[133]  Ya-Jie Tang,et al.  Myeloid derived suppressor cells contribute to the malignant progression of oral squamous cell carcinoma , 2020, PloS one.

[134]  Chunhua Huang,et al.  Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes. , 2020, International journal of biological macromolecules.

[135]  M. Ono Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes , 2020, Immunology.

[136]  D. Fruci,et al.  Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors , 2020, Frontiers in Immunology.

[137]  D. Campana,et al.  NK cells for cancer immunotherapy , 2020, Nature Reviews Drug Discovery.

[138]  S. Willems,et al.  The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis , 2020, Oncoimmunology.

[139]  J. Schlom,et al.  Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models , 2019, Clinical Cancer Research.

[140]  D. Pardoll,et al.  Mechanisms regulating PD-L1 expression on tumor and immune cells , 2019, Journal of Immunotherapy for Cancer.

[141]  M. Najafi,et al.  Stromal reprogramming: A target for tumor therapy. , 2019, Life sciences.

[142]  Liliana Borges de Menezes,et al.  Tumor microenvironment components: Allies of cancer progression. , 2019, Pathology, research and practice.

[143]  H. Li,et al.  CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer , 2019, Journal of dental research.

[144]  J. Bouček,et al.  Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells , 2019, Journal of Immunotherapy for Cancer.

[145]  M. Moriyama,et al.  CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production , 2019, Scientific Reports.

[146]  L. Que,et al.  The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway , 2019, Journal of Cancer.

[147]  M. Vered,et al.  Metastatic tumors in oral mucosa and jawbones: Unusual primary origins and unusual oral locations. , 2019, Acta histochemica.

[148]  Yong Jiang,et al.  HIF-1α Regulates Proliferation and Invasion of Oral Cancer Cells through Kv3.4 Channel. , 2019, Annals of clinical and laboratory science.

[149]  G. Descamps,et al.  Impact of HPV Infection on the Immune System in Oropharyngeal and Non-Oropharyngeal Squamous Cell Carcinoma: A Systematic Review , 2019, Cells.

[150]  Xuehao Wang,et al.  Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities , 2019, Molecular Cancer.

[151]  Siwei Wang,et al.  Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy , 2019, Journal of Hematology & Oncology.

[152]  A. Kulkarni,et al.  Blockade of TIGIT/CD155 Signaling Reverses T-cell Exhaustion and Enhances Antitumor Capability in Head and Neck Squamous Cell Carcinoma , 2019, Cancer Immunology Research.

[153]  M. Jolly,et al.  Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression , 2019, Biomolecules.

[154]  Xuan Zhou,et al.  Expansion of PMN-myeloid derived suppressor cells and their clinical relevance in patients with oral squamous cell carcinoma. , 2019, Oral oncology.

[155]  Bin Zhang,et al.  Cancer-associated fibroblast-derived exosomal miR-382-5p promotes the migration and invasion of oral squamous cell carcinoma , 2019, Oncology reports.

[156]  L. Shevde,et al.  The Tumor Microenvironment Innately Modulates Cancer Progression. , 2019, Cancer research.

[157]  Li‐yu Lee,et al.  Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation , 2019, Journal of Cancer.

[158]  S. Sakaguchi,et al.  Targeting Treg cells in cancer immunotherapy , 2019, European journal of immunology.

[159]  Michel DuPage,et al.  Treg programming and therapeutic reprogramming in cancer , 2019, Immunology.

[160]  Ying Yang,et al.  Strategies to Augment Natural Killer (NK) Cell Activity against Solid Tumors , 2019, Cancers.

[161]  T. Macfarlane,et al.  Mouth Cancer Awareness in General Population: Results from Grampian Region of Scotland, United Kingdom , 2019, Journal of oral & maxillofacial research.

[162]  R. Smolarczyk,et al.  Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy , 2019, International journal of molecular sciences.

[163]  Guan Sun,et al.  Mechanisms and therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy. , 2019, Cancer letters.

[164]  H. Nishikawa,et al.  Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target? , 2019, Cancer science.

[165]  A. Jimeno,et al.  Macrophages Promote Growth of Squamous Cancer Independent of T cells , 2019, Journal of dental research.

[166]  W. Guo,et al.  Altered expression of TIM-3, LAG-3, IDO, PD-L1, and CTLA-4 during nimotuzumab therapy correlates with responses and prognosis of oral squamous cell carcinoma patients. , 2019, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[167]  H. Eltzschig,et al.  Hypoxia signaling in human diseases and therapeutic targets , 2019, Experimental & Molecular Medicine.

[168]  Longjiang Li,et al.  CXCL12 is associated with FoxP3+ tumor-infiltrating lymphocytes and affects the survival of patients with oral squamous cell carcinoma , 2019, Oncology letters.

[169]  T. Whiteside,et al.  Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma , 2019, Cancer Immunology, Immunotherapy.

[170]  Guo-Yuan Yang,et al.  MicroRNA-210-3p Targets RGMA to Enhance the Angiogenic Functions of Endothelial Progenitor Cells Under Hypoxic Conditions , 2019, Front. Cell. Neurosci..

[171]  C. Sautès-Fridman,et al.  Tertiary lymphoid structures in the era of cancer immunotherapy , 2019, Nature Reviews Cancer.

[172]  Wenhuan Bu,et al.  CXCL12/CXCR4 pathway orchestrates CSC‐like properties by CAF recruited tumor associated macrophage in OSCC , 2019, Experimental cell research.

[173]  S. Diao,et al.  MiR-495/IGF-1/AKT Signaling as a Novel Axis Is Involved in the Epithelial-to-Mesenchymal Transition of Oral Squamous Cell Carcinoma. , 2019, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[174]  Pengfei Diao,et al.  Preoperative circulating platelet, neutrophil, and lymphocyte counts predict survival in oral cancer. , 2019, Oral diseases.

[175]  W. González-Arriagada,et al.  Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth , 2019, Medicina oral, patologia oral y cirugia bucal.

[176]  Johannes A Eble,et al.  The extracellular matrix in tumor progression and metastasis , 2019, Clinical & Experimental Metastasis.

[177]  Miao-Fen Chen,et al.  The prognosis of head and neck squamous cell carcinoma related to immunosuppressive tumor microenvironment regulated by IL-6 signaling. , 2019, Oral oncology.

[178]  Jinsong Li,et al.  Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[179]  Ryan J Li,et al.  Contemporary Treatment of Locally Advanced Oral Cancer , 2019, Current Treatment Options in Oncology.

[180]  S. Karam,et al.  STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. , 2019, Journal of the National Cancer Institute.

[181]  M. Samuel,et al.  Rho-ROCK signaling regulates tumor-microenvironment interactions. , 2019, Biochemical Society transactions.

[182]  Yong-mei Yang,et al.  CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer. , 2019, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[183]  E. Deutsch,et al.  CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance , 2019, Cancer Immunology Research.

[184]  H. Hiratsuka,et al.  Tumor‐infiltrating CD8+ T‐cell density is an independent prognostic marker for oral squamous cell carcinoma , 2019, Cancer medicine.

[185]  Xin-hua Liang,et al.  γδTDEs: An Efficient Delivery System for miR-138 with Anti-tumoral and Immunostimulatory Roles on Oral Squamous Cell Carcinoma , 2018, Molecular therapy. Nucleic acids.

[186]  Eun-sook Kim,et al.  Tumor-associated macrophages secrete CCL2 and induce the invasive phenotype of human breast epithelial cells through upregulation of ERO1-α and MMP-9. , 2018, Cancer letters.

[187]  T. Luedde,et al.  The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers , 2018, Cellular and Molecular Gastroenterology and Hepatology.

[188]  Chelsea K Martin,et al.  Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma , 2018, Cancers.

[189]  Jianfeng Liang,et al.  Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p , 2018, EBioMedicine.

[190]  M. McBurney,et al.  Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade , 2018, The Journal of clinical investigation.

[191]  E. Tartour,et al.  Resident memory T cells, critical components in tumor immunology , 2018, Journal of Immunotherapy for Cancer.

[192]  O. Stasikowska-Kanicka,et al.  CD8+ and CD163+ infiltrating cells and PD‐L1 immunoexpression in oral leukoplakia and oral carcinoma , 2018, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[193]  G. Zhu,et al.  Tumor-associated macrophages derived CCL18 promotes metastasis in squamous cell carcinoma of the head and neck , 2018, Cancer Cell International.

[194]  M. S. Yousefi,et al.  Esophageal cancer in the world: incidence, mortality and risk factors , 2018, Biomedical Research and Therapy.

[195]  Jianjun Zhang,et al.  M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma , 2018, Journal of experimental & clinical cancer research : CR.

[196]  G. Konjević,et al.  IL-2 And IL-15 Induced NKG2D, CD158a and CD158b Expression on T, NKT- like and NK Cell Lymphocyte Subsets from Regional Lymph Nodes of Melanoma Patients , 2018, Pathology & Oncology Research.

[197]  R. Coletta,et al.  Clinicopathological significance of chemokine receptor (CCR1, CCR3, CCR4, CCR5, CCR7 and CXCR4) expression in head and neck squamous cell carcinomas , 2018, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[198]  R. V. van Lier,et al.  Tissue-resident memory T cells at the center of immunity to solid tumors , 2018, Nature Immunology.

[199]  Jian Yu,et al.  Immunogenic effects of chemotherapy-induced tumor cell death , 2018, Genes & diseases.

[200]  N. Gupta,et al.  Does Hypoxia‐Inducible Factor ‐1 &agr; (HIF‐1&agr;) C1772T polymorphism predict short‐term prognosis in patients with oral squamous cell carcinoma (OSCC)? , 2018, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[201]  T. Salo,et al.  Prognostic value of the immunohistochemical detection of cancer‐associated fibroblasts in oral cancer: A systematic review and meta‐analysis , 2018, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[202]  Li Liu,et al.  Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma. , 2018, Archives of oral biology.

[203]  A. Ignatchenko,et al.  Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma. , 2018, Journal of proteome research.

[204]  A. Baghban,et al.  CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression , 2018, Pathology research international.

[205]  L. Ding,et al.  A novel stromal lncRNA signature reprograms fibroblasts to promote the growth of oral squamous cell carcinoma via LncRNA-CAF/interleukin-33 , 2018, Carcinogenesis.

[206]  A. Ihan,et al.  Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer , 2018, BMC Cancer.

[207]  Y. Wong,et al.  The correlation between HIF‐1 alpha and VEGF in oral squamous cell carcinomas: Expression patterns and quantitative immunohistochemical analysis , 2017, Journal of the Chinese Medical Association : JCMA.

[208]  J. Bergh,et al.  An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression , 2017, Cancer cell.

[209]  Chunsheng Zhang,et al.  Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. , 2017, Cancer cell.

[210]  L. Liu,et al.  [Effect of concurrent chemoradiotherapy and radiotherapy alone on peripheral myeloid-derived suppressor and T regulatory cells in patients with nasopharyngeal cancer]. , 2017, Zhonghua zhong liu za zhi [Chinese journal of oncology].

[211]  Suresh C. Sharma,et al.  Dynamics of regulatory T cells (Tregs) in patients with oral squamous cell carcinoma , 2017, Journal of surgical oncology.

[212]  S. A. Khurram,et al.  Cancer-associated fibroblasts promote bone invasion in oral squamous cell carcinoma , 2017, British Journal of Cancer.

[213]  T. Petrova,et al.  Microenvironmental regulation of tumour angiogenesis , 2017, Nature Reviews Cancer.

[214]  O. Stasikowska-Kanicka,et al.  Immunohistochemical Analysis of Foxp3+, CD4+, CD8+ Cell Infiltrates and PD-L1 in Oral Squamous Cell Carcinoma , 2017, Pathology & Oncology Research.

[215]  Y. Yen,et al.  Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression , 2017, Nature Communications.

[216]  A. Kulkarni,et al.  Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma , 2017, Molecular Cancer.

[217]  Tithi Ghosh,et al.  Tumor promoting role of anti-tumor macrophages in tumor microenvironment. , 2017, Cellular immunology.

[218]  Ziling Liu,et al.  MDSCs are involved in the protumorigenic potentials of GM-CSF in colitis-associated cancer , 2017, International journal of immunopathology and pharmacology.

[219]  M. Moriyama,et al.  CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma , 2017, Scientific Reports.

[220]  Min Li,et al.  Tumor cells PD-L1 expression as a favorable prognosis factor in nasopharyngeal carcinoma patients with pre-existing intratumor-infiltrating lymphocytes , 2017, Oncoimmunology.

[221]  J. Koch,et al.  Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma , 2017, Front. Immunol..

[222]  Muhammad Sohail Zafar,et al.  Salivary IL-8, IL-6 and TNF-α as Potential Diagnostic Biomarkers for Oral Cancer , 2017, Diagnostics.

[223]  Jian-yun Dong,et al.  Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[224]  Miao-Fen Chen,et al.  Inflammation‐induced myeloid‐derived suppressor cells associated with squamous cell carcinoma of the head and neck , 2017, Head & neck.

[225]  Xia Li,et al.  MiR‐124 down‐regulation is critical for cancer associated fibroblasts‐enhanced tumor growth of oral carcinoma , 2017, Experimental cell research.

[226]  Ping Zhang,et al.  Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion , 2016, Journal of experimental & clinical cancer research : CR.

[227]  Dong Mei,et al.  Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[228]  R. Agarwal,et al.  Implications of cancer stem cells in developing therapeutic resistance in oral cancer. , 2016, Oral oncology.

[229]  Yingchun Dong,et al.  Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis , 2016, Scientific Reports.

[230]  R. Murakami,et al.  IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma , 2016, British Journal of Cancer.

[231]  Hong-Min Kim,et al.  Interleukin-10 attenuates tumour growth by inhibiting interleukin-6/signal transducer and activator of transcription 3 signalling in myeloid-derived suppressor cells. , 2016, Cancer letters.

[232]  M. Noguchi,et al.  Enhanced expression of PD-L1 in oral squamous cell carcinoma-derived CD11b(+)Gr-1(+) cells and its contribution to immunosuppressive activity. , 2016, Oral oncology.

[233]  K. E. Visser,et al.  Neutrophils in cancer: neutral no more , 2016, Nature Reviews Cancer.

[234]  I. Tohnai,et al.  M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation , 2016, Scientific Reports.

[235]  Xuetao Cao,et al.  Immunosuppressive cells in tumor immune escape and metastasis , 2016, Journal of Molecular Medicine.

[236]  Qianming Chen,et al.  Regulatory T cells in oral squamous cell carcinoma. , 2016, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[237]  Xiao Jiang,et al.  Elevated autocrine chemokine ligand 18 expression promotes oral cancer cell growth and invasion via Akt activation , 2016, Oncotarget.

[238]  Jianxing He,et al.  Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer , 2016, Oncotarget.

[239]  Tao Yin,et al.  Targeting of cancer-associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironment , 2016, Molecular medicine reports.

[240]  Tonya J. Webb,et al.  Human Head and Neck Squamous Cell Carcinoma–Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells , 2016, The Journal of Immunology.

[241]  Yu-xiong Su,et al.  CD19(+)IL-10(+) regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4(+) T cells to CD4(+)Foxp3(+) regulatory T cells. , 2016, Oral oncology.

[242]  R. Boidot,et al.  Tumor infiltration by Tbet+ effector T cells and CD20+ B cells is associated with survival in gastric cancer patients , 2016, Oncoimmunology.

[243]  H. Youssef,et al.  Correlation of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) expressions with clinico-pathological features of oral squamous cell carcinoma (OSCC) , 2015 .

[244]  J. Koch,et al.  Cetuximab Reconstitutes Pro-Inflammatory Cytokine Secretions and Tumor-Infiltrating Capabilities of sMICA-Inhibited NK Cells in HNSCC Tumor Spheroids , 2015, Front. Immunol..

[245]  S. Hugues,et al.  Th17 Cell Plasticity and Functions in Cancer Immunity , 2015, BioMed research international.

[246]  Y. Ohmori,et al.  Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment , 2015, BMC Cancer.

[247]  Ayyaz Ali Khan,et al.  Salivary Immunosuppressive Cytokines IL-10 and IL-13 Are Significantly Elevated in Oral Squamous Cell Carcinoma Patients , 2015, Cancer investigation.

[248]  Di Wang,et al.  Pro-Inflammatory Cytokine IL-1β Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma , 2015, PloS one.

[249]  Shih-Ming Huang,et al.  Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma. , 2015, Oral oncology.

[250]  Fumito Ito,et al.  Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL‐10 , 2015, European journal of immunology.

[251]  S. Schokrpur,et al.  CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy. , 2015, Cancer research.

[252]  Jennifer D. Wu,et al.  NKG2D Ligands in Tumor Immunity: Two Sides of a Coin , 2015, Front. Immunol..

[253]  H. Nakayama,et al.  The tumour stromal features are associated with resistance to 5‐FU‐based chemoradiotherapy and a poor prognosis in patients with oral squamous cell carcinoma , 2015, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[254]  L. Ding,et al.  Microlocalization of CD68+ tumor-associated macrophages in tumor stroma correlated with poor clinical outcomes in oral squamous cell carcinoma patients , 2015, Tumor Biology.

[255]  S. Singhal,et al.  Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. , 2014, The Journal of clinical investigation.

[256]  M. Jo,et al.  uPAR induces expression of transforming growth factor β and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. , 2014, The American journal of pathology.

[257]  J. Califano,et al.  Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma , 2014, Clinical Cancer Research.

[258]  T. Yoshino,et al.  Regulatory T-cell infiltration in tongue squamous cell carcinoma , 2014, Acta oto-laryngologica.

[259]  Amber J. Giles,et al.  Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy , 2014, Science Translational Medicine.

[260]  Zhi-Li Zhao,et al.  CD163+ Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma , 2014, BioMed research international.

[261]  G. Di Lullo,et al.  Tumor antigen-specific CD4+ T cells in cancer immunity: from antigen identification to tumor prognosis and development of therapeutic strategies. , 2014, Tissue antigens.

[262]  D. Ribeiro,et al.  Effective targeting of the epidermal growth factor receptor (EGFR) for treating oral cancer: a promising approach. , 2014, Anticancer research.

[263]  M. Augsten Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment , 2014, Front. Oncol..

[264]  S. Dey,et al.  CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. , 2013, Cancer cell.

[265]  Y. Usami,et al.  Intercellular adhesion molecule‐1 (ICAM‐1) expression correlates with oral cancer progression and induces macrophage/cancer cell adhesion , 2013, International journal of cancer.

[266]  T. Bando,et al.  Immunochemoradiotherapy for patients with oral squamous cell carcinoma: augmentation of OK-432-induced helper T cell 1 response by 5-FU and X-ray irradiation. , 2013, Neoplasia.

[267]  Stephen Mok,et al.  CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. , 2013, Cancer research.

[268]  H. Zhang,et al.  STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. , 2013, The Journal of clinical investigation.

[269]  D. Speiser,et al.  Prognostic value of arginase‐II expression and regulatory T‐cell infiltration in head and neck squamous cell carcinoma , 2013, International journal of cancer.

[270]  J. Thariat,et al.  Oral complications of cancer and cancer therapy , 2012, CA: a cancer journal for clinicians.

[271]  Seiji Nakamura,et al.  In vitro induction of specific CD8+ T lymphocytes by tumor-associated antigenic peptides in patients with oral squamous cell carcinoma. , 2012, Cancer letters.

[272]  P. Watson,et al.  CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27− Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian Cancer , 2012, Clinical Cancer Research.

[273]  J. Ha,et al.  Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1α. , 2012, Toxicology in vitro : an international journal published in association with BIBRA.

[274]  J. Wolchok,et al.  Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment. , 2011, Cancer research.

[275]  Kyeong Lee,et al.  A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor , 2011, Archives of pharmacal research.

[276]  F. Cappello,et al.  Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein , 2011, Infectious Agents and Cancer.

[277]  Y. Ohmori,et al.  Infiltration of M2 Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma Correlates with Tumor Malignancy , 2011, Cancers.

[278]  S. Anil,et al.  Tumour infiltrating CD25+ FoxP3+ regulatory T cells (Tregs) relate to tumour grade and stromal inflammation in oral squamous cell carcinoma. , 2011, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[279]  M. Kuo,et al.  HDAC2 promotes cell migration/invasion abilities through HIF-1α stabilization in human oral squamous cell carcinoma. , 2011, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[280]  J. Talmadge,et al.  Tumor- and organ-dependent infiltration by myeloid-derived suppressor cells. , 2011, International immunopharmacology.

[281]  D. Zopf,et al.  Regorafenib (BAY 73‐4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity , 2011, International journal of cancer.

[282]  Hsiao-Chin Hong,et al.  Targeting Galectin-1 in Carcinoma-Associated Fibroblasts Inhibits Oral Squamous Cell Carcinoma Metastasis by Downregulating MCP-1/CCL2 Expression , 2011, Clinical Cancer Research.

[283]  P. Weinreb,et al.  Stromal features are predictive of disease mortality in oral cancer patients , 2011, The Journal of pathology.

[284]  D. El-Rouby Association of macrophages with angiogenesis in oral verrucous and squamous cell carcinomas. , 2010, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[285]  Darren R. Williams,et al.  Tumor‐stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7 , 2010, International journal of cancer.

[286]  G. Hostetter,et al.  Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer , 2010, Molecular Cancer Therapeutics.

[287]  Santosh K. Ghosh,et al.  An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking via the Chemokine Receptor CCR2, a Model for Tumorigenesis , 2010, PloS one.

[288]  T. Wong,et al.  ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction. , 2010, European journal of cancer.

[289]  G. Garlet,et al.  Patients with oral squamous cell carcinoma are characterized by increased frequency of suppressive regulatory T cells in the blood and tumor microenvironment , 2010, Cancer Immunology, Immunotherapy.

[290]  R. Herbst,et al.  Results from a phase I, dose-escalation study of PX-478, an orally available inhibitor of HIF-1{alpha}. , 2010 .

[291]  H. Ohtani,et al.  Tumor-infiltrating lymphocytes, particularly the balance between CD8(+) T cells and CCR4(+) regulatory T cells, affect the survival of patients with oral squamous cell carcinoma. , 2010, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[292]  Y. DeClerck,et al.  Bone marrow-derived mesenchymal stem cells and the tumor microenvironment , 2010, Cancer and Metastasis Reviews.

[293]  Xiaopei Huang,et al.  Direct TLR2 Signaling Is Critical for NK Cell Activation and Function in Response to Vaccinia Viral Infection , 2010, PLoS pathogens.

[294]  J. Bankson,et al.  The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects , 2009, Molecular Cancer Therapeutics.

[295]  S. Toda,et al.  Irradiated fibroblast‐induced bystander effects on invasive growth of squamous cell carcinoma under cancer–stromal cell interaction , 2008, Cancer science.

[296]  Xin-hua Liang,et al.  Hypoxia Inducible Factor-1alpha Expression Correlates with Vascular Endothelial Growth Factor-C Expression and Lymphangiogenesis/Angiogenesis in Oral Squamous Cell Carcinoma , 2008 .

[297]  D. Cole,et al.  Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model , 2008, Cancer Immunology, Immunotherapy.

[298]  A. Phillips,et al.  Hyaluronan Facilitates Transforming Growth Factor-β1-mediated Fibroblast Proliferation* , 2008, Journal of Biological Chemistry.

[299]  Y. Hung,et al.  Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma. , 2008, Oral oncology.

[300]  W. Gerner,et al.  Synergistic effects of IL-2, IL-12 and IL-18 on cytolytic activity, perforin expression and IFN-gamma production of porcine natural killer cells. , 2008, Veterinary immunology and immunopathology.

[301]  E. Sahai,et al.  Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells , 2007, Nature Cell Biology.

[302]  H. Einsele,et al.  Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells , 2007, BMC Cancer.

[303]  D. Nelson,et al.  Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells , 2007, Cell biology international.

[304]  T. Osaki,et al.  The involvement of hypoxia‐inducible factor‐1α in the susceptibility to γ‐rays and chemotherapeutic drugs of oral squamous cell carcinoma cells , 2007 .

[305]  N. Denko,et al.  HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. , 2006, Cell metabolism.

[306]  M. Quintero,et al.  Hypoxia-inducible factor 1alpha in oral cancer. , 2005, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[307]  J. Joyce,et al.  Therapeutic Targeting of the Tumor Microenvironment. , 2021, Cancer discovery.

[308]  Zuo-Feng Zhang,et al.  Treatment with siRNA and antisense oligonucleotides targeted to HIF‐1α induced apoptosis in human tongue squamous cell carcinomas , 2004, International journal of cancer.

[309]  L. Neckers,et al.  IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis , 2003 .

[310]  P. Johnston,et al.  5-Fluorouracil: mechanisms of action and clinical strategies , 2003, Nature Reviews Cancer.

[311]  Y. Ron,et al.  Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. , 2001, International immunology.

[312]  G. Dong,et al.  Growth Regulated Oncogene-α expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC Receptor-2 dependent mechanism , 2000, Oncogene.

[313]  C. Van Waes,et al.  The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC , 1998, Clinical & Experimental Metastasis.

[314]  J. Trapani,et al.  Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization , 1997, The Journal of experimental medicine.

[315]  Y. Cho,et al.  CCL7 Signaling in the Tumor Microenvironment. , 2020, Advances in experimental medicine and biology.

[316]  L. Hartner Chemotherapy for Oral Cancer. , 2018, Dental clinics of North America.

[317]  Bin Zhou,et al.  Cancer-associated fibroblasts confer cisplatin resistance of tongue cancer via autophagy activation. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[318]  F. Tacke,et al.  M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment. , 2016, Cancer research.

[319]  Y. Su,et al.  Myeloid-derived suppressor cells contribute to oral cancer progression in 4NQO-treated mice. , 2012, Oral diseases.

[320]  Yun-Jin Jung,et al.  IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.