Facilitation of transmitter release at squid synapses

Facilitation is shown to decay as a compound exponential with two time constants (T1, T2) at both giant and non-giant synapses in squid stellate ganglia bathed in solutions having low extracellular calcium concentrations ([Ca++]o). Maximum values of facilitation (F1) were significantly larger, and T1 was significantly smaller in giant than non-giant synapses. Decreases in [Ca++]o or increases in [Mn++]o had variable effects on T1 and F1, whereas decreases in temperature increased T1 but had insignificant effects on F1. The growth of facilitation during short trains of equal interval stimuli was adequately predicted by the linear summation model developed by Mallart and Martin (1967. J. Physiol. (Lond.). 193:676--694) for frog neuromuscular junctions. This result suggests that the underlying mechanisms of facilitation are similar in squid and other synapses which release many transmitter quanta.

[1]  John Zachary Young,et al.  Fused Neurons and Synaptic Contacts in the Giant Nerve Fibres of Cephalopods , 1939 .

[2]  B. Katz,et al.  Statistical factors involved in neuromuscular facilitation and depression , 1954, The Journal of physiology.

[3]  A. R. Martin,et al.  A further study of the statistical composition of the end‐plate potential , 1955, The Journal of physiology.

[4]  S. W. Kuffler,et al.  Mechanism of facilitation at the crayfish neuromuscular junction , 1961, The Journal of physiology.

[5]  A. Takeuchi,et al.  Electrical Changes in Pre- and Postsynaptic Axons of the Giant Synapse of Loligo , 1962, The Journal of general physiology.

[6]  M. Kuno.  Mechanism of facilitation and depression of the excitatory synaptic potential in spinal motoneurones , 1964, The Journal of physiology.

[7]  R. Llinás,et al.  Transmitter Release at the Squid Giant Synapse in the Presence of Tetrodotoxin , 1966, Nature.

[8]  R. Miledi,et al.  The action of calcium on neuronal synapses in the squid , 1966, The Journal of physiology.

[9]  B. Katz,et al.  A study of synaptic transmission in the absence of nerve impulses , 1967, The Journal of physiology.

[10]  R. Miledi,et al.  Spontaneous synaptic potentials and quantal release of transmitter in the stellate ganglion of the squid , 1967, The Journal of physiology.

[11]  A Mallart,et al.  An analysis of facilitation of transmitter release at the neuromuscular junction of the frog , 1967, The Journal of physiology.

[12]  B. Katz,et al.  The role of calcium in neuromuscular facilitation , 1968, The Journal of physiology.

[13]  R Rahamimoff,et al.  A dual effect of calcium ions on neuromuscular facilitation , 1968, The Journal of physiology.

[14]  George D. Bittner,et al.  Differentiation of Nerve Terminals in the Crayfish Opener Muscle and Its Functional Significance , 1968, The Journal of general physiology.

[15]  A Mallart,et al.  The relation between quantum content and facilitation at the neuromuscular junction of the frog , 1968, The Journal of physiology.

[16]  P. Gage,et al.  Temperature sensitivity of the time course of facilitation of transmitter release. , 1970, Brain research.

[17]  A reconsideration of the Poisson hypothesis for transmitter release at the crayfish neuromuscular junction , 1970, The Journal of physiology.

[18]  M. Endo,et al.  Calcium Induced Release of Calcium from the Sarcoplasmic Reticulum of Skinned Skeletal Muscle Fibres , 1970, Nature.

[19]  R. J. Podolsky,et al.  Regenerative Calcium Release within Muscle Cells , 1970, Science.

[20]  M. Endo,et al.  Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. , 1970, Nature.

[21]  R. Miledi,et al.  Tetanic and post‐tetanic rise in frequency of miniature end‐plate potentials in low‐calcium solutions , 1971, The Journal of physiology.

[22]  Baker Pf,et al.  Depolarization and calcium entry in squid giant axons. , 1971 .

[23]  R Rahamimoff,et al.  Neuromuscular Transmission: Inhibition by Manganese Ions , 1972, Science.

[24]  C. Stevens,et al.  The kinetics of transmitter release at the frog neuromuscular junction , 1972, The Journal of physiology.

[25]  K L Magleby,et al.  The effect of repetitive stimulation on facilitation of transmitter release at the frog neuromuscular junction , 1973, The Journal of physiology.

[26]  P. Gage,et al.  The inhibitory effect of manganese on transmitter release at the neuromuscular junction of the toad , 1973, British journal of pharmacology.

[27]  R. Porter,et al.  The effect of a preceding stimulus on temporal facilitation at corticomotoneuronal synapses , 1973, The Journal of physiology.

[28]  K. Magleby.  The effect of tetanic and post‐tetanic potentiation on facilitation of transmitter release at the frog neuromuscular junction , 1973, The Journal of physiology.

[29]  Y. Yaari,et al.  Delayed release of transmitter at the frog neuromuscular junction , 1973, The Journal of physiology.

[30]  T. M. Linder.  Calcium and Facilitation at Two Classes of Crustacean Neuromuscular Synapses , 1973, The Journal of general physiology.

[31]  N. Daw,et al.  A guide to laboratory use of the squid Loligo pealei , 1974 .

[32]  P. Gage,et al.  On facilitation of transmitter release at the toad neuromuscular junction , 1974, The Journal of physiology.

[33]  T. Hendriks,et al.  Biochemical aspects of the visual process. XXV. Light-induced calcium movements in isolated frog rod outer segments , 1974 .

[34]  R. Zucker.  Characteristics of crayfish neuromuscular facilitation and their calcium dependence , 1974, The Journal of physiology.

[35]  T. M. Linder.  The accumulative properties of facilitation at crayfish neuromuscular synapses , 1974, The Journal of physiology.

[36]  S. Younkin,et al.  An analysis of the role of calcium in facilitation at the frog neuromuscular junction , 1974, The Journal of physiology.

[37]  R Llinás,et al.  Calcium role in depolarization-secretion coupling: an aequorin study in squid giant synapse. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. Bennett,et al.  The effect of calcium ions on the binomial statistic parameters which control acetylcholine release at synapses in striated muscle. , 1975, The Journal of physiology.

[39]  E. MacLachlan.  An analysis of the release of acetylcholine from preganglionic nerve terminals. , 1975 .

[40]  K Kusano,et al.  Depression and recovery of transmission at the squid giant synapse. , 1975, The Journal of physiology.

[41]  E. McLachlan.  An analysis of the release of acetylcholine from preganglionic nerve terminals. , 1975, The Journal of physiology.

[42]  F. F. Weight,et al.  Synaptic transmission and effects of temperature at the squid giant synapse , 1976, Nature.

[43]  H. Atwood,et al.  Organization and synaptic physiology of crustacean neuromuscular systems , 1976, Progress in Neurobiology.

[44]  M. Charlton,et al.  Presynaptic potentials and facilitation of transmitter release in the squid giant synapse , 1978, The Journal of general physiology.