Optimization of Fermentative Production of Keratinase by Bacillus subtilis Strain S1 in Submerged State Fermentation Using Feather Waste

Keratinases are well-acknowledged enzymes with the extraordinary power of taking down the unmanageable structural proteins such as keratin. Their prospective in bio-waste management of feather waste has been well established since long. In present scenario, they have acquired significance in various other industrial applications. A massive amount of fibrous insoluble protein in the form of feathers, hair, nails, horn, and other are available as byproducts of agroindustrial processing plants (Onifade et al., 1998). These keratinous wastes are very tough to degrade because of the densely packed polypeptide and several hydrogen bonds and hydrophobic interactions, in addition to several disulfide bonds. Keratin is the insoluble structural protein of feathers and wool and is known for its high stability (Bradbury 1973). In spite of their prominent resistance, keratins do not mount up in nature and can be hydrolyzed by a number of International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 12 (2017) pp. 1499-1510 Journal homepage: http://www.ijcmas.com

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