The impact of the endoplasmic reticulum protein-folding environment on cancer development
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[1] Birgit Kasch,et al. Next Generation , 2016, Im OP.
[2] Dustin J Maly,et al. Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress , 2014, Cell.
[3] D. Lawrence,et al. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis , 2014, Science.
[4] Y. Liu,et al. A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level , 2014, International journal of cancer.
[5] Lukasz Kurgan,et al. Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis , 2014, Science Signaling.
[6] C. Cubitt,et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. , 2014, The Journal of clinical investigation.
[7] N. Hockstein,et al. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. , 2014, The Journal of clinical investigation.
[8] T. Fotsis,et al. VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress. , 2014, Molecular cell.
[9] D. Bowtell,et al. Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2 , 2014, PLoS genetics.
[10] E. Sokol,et al. Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. , 2014, Cancer discovery.
[11] M. Ferrari,et al. XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway , 2014, Nature.
[12] M. Herlyn,et al. Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. , 2014, The Journal of clinical investigation.
[13] T. Gidalevitz,et al. Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association. , 2014, Molecular cell.
[14] J. Marchal,et al. The impact of PKR activation: from neurodegeneration to cancer , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[15] H. Tseng,et al. Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress. , 2014, Cellular signalling.
[16] P. Horák,et al. TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo , 2014, Scientific Reports.
[17] A. Koromilas,et al. Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications , 2014, Cell cycle.
[18] L. Hendershot,et al. Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)* , 2013, The Journal of Biological Chemistry.
[19] A. Strasser,et al. ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis , 2013, Cell Death and Differentiation.
[20] P. Boutros,et al. Two phases of disulfide bond formation have differing requirements for oxygen , 2013, The Journal of cell biology.
[21] J. Debnath,et al. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK , 2013, Oncogene.
[22] A. Kaser,et al. Paneth cells as a site of origin for intestinal inflammation , 2013, Nature.
[23] H. Tilg,et al. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells , 2013, The Journal of experimental medicine.
[24] H. Perlman,et al. Toll‐like receptor‐mediated IRE1α activation as a therapeutic target for inflammatory arthritis , 2013, The EMBO journal.
[25] J. Keats,et al. Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma. , 2013, Cancer cell.
[26] Soyoung Lee,et al. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy , 2013, Nature.
[27] Yu Ning,et al. Amino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway. , 2013, Neoplasia.
[28] G. Juhász,et al. Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster , 2013, PLoS genetics.
[29] V. Carraro,et al. The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression , 2013, Nucleic acids research.
[30] T. Hagen,et al. Multiple myeloma Leu167Ile (c.499C>A) mutation prevents XBP1 mRNA splicing , 2013, British journal of haematology.
[31] P. Walter,et al. The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. , 2013, Cell host & microbe.
[32] T. Graeber,et al. An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. , 2013, Cancer research.
[33] R. Kaufman,et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death , 2013, Nature Cell Biology.
[34] Daniel P. Stewart,et al. The Unfolded Protein Response Selectively Targets Active Smoothened Mutants , 2013, Molecular and Cellular Biology.
[35] Y. Kimata,et al. BiP‐bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response , 2013, Genes to cells : devoted to molecular & cellular mechanisms.
[36] F. Fauvet,et al. p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose. , 2013, Molecular cell.
[37] Qingbo Xu,et al. Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis , 2013, Circulation.
[38] K. Mishiba,et al. Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response , 2013, Proceedings of the National Academy of Sciences.
[39] Brent M. Sanders,et al. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. , 2013, Cancer research.
[40] P. Lambin,et al. PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS , 2013, Proceedings of the National Academy of Sciences.
[41] D. Ron,et al. Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains , 2013, Proceedings of the National Academy of Sciences.
[42] Yup Kang,et al. Exendin-4 inhibits glucolipotoxic ER stress in pancreatic β cells via regulation of SREBP1c and C/EBPβ transcription factors. , 2013, The Journal of endocrinology.
[43] Helmut Klocker,et al. Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis , 2013, BMC Cancer.
[44] S. Cohen,et al. ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation. , 2013, Genes & development.
[45] M. Zanetti,et al. Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8+ T Cell Priming , 2012, PloS one.
[46] I. Mills,et al. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. , 2012, The Journal of clinical investigation.
[47] D. R. Laybutt,et al. The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions , 2012, Molecular and Cellular Endocrinology.
[48] L. Chodosh,et al. miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. , 2012, Molecular cell.
[49] Michael T. McManus,et al. IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2 , 2012, Science.
[50] A. Hoffmann,et al. ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK , 2012, PloS one.
[51] F. Visioli,et al. The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway. , 2012, Cancer research.
[52] H. Chung,et al. Annals of the New York Academy of Sciences Unfolded Protein Response to Autophagy as a Promising Druggable Target for Anticancer Therapy , 2022 .
[53] Ming Li,et al. An Immunosurveillance Mechanism Controls Cancer Cell Ploidy , 2012, Science.
[54] J. Ko,et al. Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells. , 2012, Toxicology and applied pharmacology.
[55] F. Urano,et al. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. , 2012, Cell metabolism.
[56] A. Harris,et al. The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress , 2012, Oncogene.
[57] P. Greengard,et al. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. , 2012, Cell metabolism.
[58] M. Pollheimer,et al. Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice , 2012, Hepatology.
[59] P. Agostinis,et al. PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress , 2012, Cell Death and Differentiation.
[60] K. Mori,et al. An IFN-γ–stimulated ATF6–C/EBP-β–signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy , 2012, Proceedings of the National Academy of Sciences.
[61] Suxin Luo,et al. RETRACTED ARTICLE: XBP1S protects cells from ER stress-induced apoptosis through Erk1/2 signaling pathway involving CHOP , 2012, Histochemistry and Cell Biology.
[62] L. Olson,et al. A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. , 2012, American journal of physiology. Endocrinology and metabolism.
[63] L. P. Vaites,et al. PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation , 2012, Molecular and Cellular Biology.
[64] Jisu Oh,et al. Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation* , 2012, The Journal of Biological Chemistry.
[65] R. Silverman,et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule , 2012, Proceedings of the National Academy of Sciences.
[66] Gary Taubes,et al. Cancer research. Unraveling the obesity-cancer connection. , 2012, Science.
[67] S. Harrison,et al. Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1 , 2012, Haematologica.
[68] A. Tardivel,et al. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway , 2012, Cell Death and Disease.
[69] S. Kimball,et al. Toll-like receptor activation suppresses endoplasmic reticulum stress-induced CHOP and translation inhibition through activation of eIF2B , 2011, Nature Cell Biology.
[70] J. McClintick,et al. The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress , 2011, Molecular biology of the cell.
[71] Yu-mi Jang,et al. AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells , 2011, Brain Research.
[72] T. Alain,et al. Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death. , 2011, Cancer cell.
[73] Peter Walter,et al. Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response , 2011, Science.
[74] M. Zanetti,et al. Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells , 2011, Proceedings of the National Academy of Sciences.
[75] Lee H. Dicker,et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity , 2011, Nature.
[76] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[77] S. Nakajima,et al. Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt , 2011, Molecular and Cellular Biology.
[78] R. Wek,et al. Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation*♦ , 2011, The Journal of Biological Chemistry.
[79] T. Herbert,et al. PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells , 2010, Molecular endocrinology.
[80] David S. Park,et al. Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA , 2010, The Journal of Neuroscience.
[81] Tak W. Mak,et al. The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway , 2010, Cell.
[82] Jonathan W. Pillow,et al. POSTER PRESENTATION Open Access , 2013 .
[83] V. Saudek,et al. Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression , 2010, Proceedings of the National Academy of Sciences.
[84] Linda M. Hendershot,et al. Transcriptional and Post-Transcriptional Regulation of Proangiogenic Factors by the Unfolded Protein Response , 2010, PloS one.
[85] G. Pavitt,et al. eIF5 is a dual function GAP and GDI for eukaryotic translational control. , 2010, Small GTPases.
[86] P. Walter,et al. Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering , 2010, Proceedings of the National Academy of Sciences.
[87] A. Salminen,et al. Endoplasmic Reticulum Stress in Age-Related Macular Degeneration: Trigger for Neovascularization , 2010, Molecular medicine.
[88] A. Babour,et al. A Surveillance Pathway Monitors the Fitness of the Endoplasmic Reticulum to Control Its Inheritance , 2010, Cell.
[89] C. Hetz,et al. HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction , 2010, PLoS biology.
[90] Jiangbin Ye,et al. The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation , 2010, The EMBO journal.
[91] R. Binder,et al. Ovalbumin-Derived Precursor Peptides Are Transferred Sequentially from gp96 and Calreticulin to MHC Class I in the Endoplasmic Reticulum , 2010, The Journal of Immunology.
[92] Xi Chen,et al. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages , 2010, Nature Immunology.
[93] Jiangbin Ye,et al. PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage , 2010, Oncogene.
[94] M. Karin,et al. Immunity, Inflammation, and Cancer , 2010, Cell.
[95] Z. Wang,et al. ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy , 2010, Autophagy.
[96] R. Kaufman,et al. A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1α Activation in Pancreatic β Cells , 2010, Science Signaling.
[97] Jun Hee Lee,et al. Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression , 2010, Cell.
[98] Philippe Lambin,et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. , 2010, The Journal of clinical investigation.
[99] G. Robertson,et al. Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2α Phosphorylation Pathway , 2009, Science Signaling.
[100] A. Harris,et al. Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia , 2009, Cell cycle.
[101] D. Kufe,et al. Mucins in cancer: function, prognosis and therapy , 2009, Nature Reviews Cancer.
[102] Hao Wang,et al. N‐glycosylation of ATF6β is essential for its proteolytic cleavage and transcriptional repressor function to ATF6α , 2009, Journal of cellular biochemistry.
[103] B. Sarg,et al. GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib. , 2009, Blood.
[104] Robert H. Brown,et al. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. , 2009, Genes & development.
[105] F. R. Papa,et al. IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates , 2009, Cell.
[106] S. Nakajima,et al. Activation of the Akt-NF-κB Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response1 , 2009, The Journal of Immunology.
[107] D. Scheuner,et al. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. , 2009, Cell metabolism.
[108] Hua Yu,et al. IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway , 2009, The Journal of experimental medicine.
[109] K. Shin‐ya,et al. Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. , 2009, Cancer research.
[110] K. Takada,et al. Endoplasmic reticulum stress triggers XBP-1-mediated up-regulation of an EBV oncoprotein in nasopharyngeal carcinoma. , 2009, Cancer research.
[111] T. Iwawaki,et al. Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA. , 2009, Molecular cell.
[112] E. Caron,et al. ER stress affects processing of MHC class I-associated peptides , 2009, BMC Immunology.
[113] R. Kaufman,et al. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion , 2008, Proceedings of the National Academy of Sciences.
[114] J. Liu,et al. Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis , 2008, Oncogene.
[115] Qiang Sun,et al. PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1α signaling and endoplasmic reticulum stress , 2008, Development.
[116] Subramaniam Pennathur,et al. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. , 2008, The Journal of clinical investigation.
[117] N. Denko,et al. Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress , 2008, Molecular and Cellular Biology.
[118] F. Khuri,et al. Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation. , 2008, Cancer research.
[119] Thomas C. Chen,et al. Stress Chaperone GRP78/BiP Confers Chemoresistance to Tumor-Associated Endothelial Cells , 2008, Molecular Cancer Research.
[120] J. Aguirre-Ghiso,et al. ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo , 2008, Proceedings of the National Academy of Sciences.
[121] Randal J. Kaufman,et al. From endoplasmic-reticulum stress to the inflammatory response , 2008, Nature.
[122] R. Kaufman,et al. Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum* , 2008, Journal of Biological Chemistry.
[123] M. Sahin,et al. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. , 2008, Molecular cell.
[124] B. Sugden,et al. The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis. , 2008, Blood.
[125] S. Groshen,et al. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. , 2008, Cancer research.
[126] G. Camenisch,et al. Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor. , 2007, Blood.
[127] Chao Zhang,et al. IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response , 2007, Science.
[128] R. Kaufman,et al. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? , 2007, Antioxidants & redox signaling.
[129] R. Kaufman,et al. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. , 2007, Developmental cell.
[130] Tomomi Gotoh,et al. ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim , 2007, Cell.
[131] Amy S. Lee. GRP78 induction in cancer: therapeutic and prognostic implications. , 2007, Cancer research.
[132] A. Protopopov,et al. The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis , 2007, Cancer cell.
[133] E. Birney,et al. Patterns of somatic mutation in human cancer genomes , 2007, Nature.
[134] R. Chen,et al. Inflammation, Cancer and Chemoresistance: Taking Advantage of the Toll‐Like Receptor Signaling Pathway , 2007, American journal of reproductive immunology.
[135] Y Kouroku,et al. ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation , 2007, Cell Death and Differentiation.
[136] R. Rizzuto,et al. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. , 2007, Molecular cell.
[137] Hai Hu,et al. Overexpressed Derlin-1 inhibits ER expansion in the endothelial cells derived from human hepatic cavernous hemangioma. , 2006, Journal of biochemistry and molecular biology.
[138] R. Kaufman,et al. Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins , 2006, PLoS biology.
[139] D. Ron,et al. Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress , 2006, Molecular and Cellular Biology.
[140] F. Urano,et al. Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress , 2006, Molecular and Cellular Biology.
[141] S. Gruber,et al. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway , 2006, Nature Cell Biology.
[142] Zhaohui Xu,et al. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response , 2006, Proceedings of the National Academy of Sciences.
[143] Afshin Samali,et al. Mediators of endoplasmic reticulum stress‐induced apoptosis , 2006, EMBO reports.
[144] M. Karin,et al. Double-stranded RNA-dependent Protein Kinase Phosphorylation of the α-Subunit of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis* , 2006, Journal of Biological Chemistry.
[145] Jonathan S Weissman,et al. Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response , 2006, Science.
[146] L. Boise,et al. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. , 2006, Blood.
[147] R. Kaufman,et al. Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression , 2006, Molecular and Cellular Biology.
[148] Randal J. Kaufman,et al. Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response , 2006, Cell.
[149] K. Mori,et al. Transformation‐associated gene regulation by ATF6α during hepatocarcinogenesis , 2006, FEBS letters.
[150] O. Pluquet,et al. Endoplasmic Reticulum Stress Accelerates p53 Degradation by the Cooperative Actions of Hdm2 and Glycogen Synthase Kinase 3β , 2005, Molecular and Cellular Biology.
[151] D. Scheuner,et al. ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth , 2005, The EMBO journal.
[152] R. Hamanaka,et al. PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. , 2005, Molecular biology of the cell.
[153] David A. Brenner,et al. Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6 , 2005, Journal of Biological Chemistry.
[154] R. Schwabe,et al. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. , 2005, The Journal of biological chemistry.
[155] H. Hayashi,et al. TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death , 2005, The EMBO journal.
[156] D. Scheuner,et al. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. , 2005, The Journal of clinical investigation.
[157] D. Ron,et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. , 2004, Genes & development.
[158] Hong Wang,et al. Peroxynitrite-Induced Neuronal Apoptosis Is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation , 2004, The Journal of Neuroscience.
[159] H. Yamaguchi,et al. CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells* , 2004, Journal of Biological Chemistry.
[160] L. Glimcher,et al. Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.
[161] W. Arap,et al. Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. , 2004, Cancer cell.
[162] L. Staudt,et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. , 2004, Immunity.
[163] A. Yoshimura,et al. Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β , 2004 .
[164] D. Scheuner,et al. Cytoprotection by pre‐emptive conditional phosphorylation of translation initiation factor 2 , 2004, The EMBO journal.
[165] E. Wagner,et al. AP-1: a double-edged sword in tumorigenesis , 2003, Nature Reviews Cancer.
[166] Randal J. Kaufman,et al. Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival , 2003, Molecular and Cellular Biology.
[167] Marc Montminy,et al. TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver , 2003, Science.
[168] Randal J. Kaufman,et al. Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors , 2003, Journal of Biological Chemistry.
[169] A. Komar,et al. The Zipper Model of Translational Control A Small Upstream ORF Is the Switch that Controls Structural Remodeling of an mRNA Leader , 2003, Cell.
[170] K. Rajewsky,et al. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 , 2003, Nature Immunology.
[171] L. Neckers,et al. Heat Shock Protein 90 Modulates the Unfolded Protein Response by Stabilizing IRE1α , 2002, Molecular and Cellular Biology.
[172] N. Sonenberg,et al. Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α , 2002, Molecular and Cellular Biology.
[173] Hiderou Yoshida,et al. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. , 2002, Genes & development.
[174] Stevan R. Hubbard,et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA , 2002, Nature.
[175] K. Mori,et al. XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor , 2001, Cell.
[176] D. Scheuner,et al. Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[177] Neal N. Iwakoshi,et al. Plasma cell differentiation requires the transcription factor XBP-1 , 2001, Nature.
[178] E McEwen,et al. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. , 2001, Molecular cell.
[179] D. Ron,et al. Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α , 2001, The Journal of cell biology.
[180] R. Ghosh,et al. Eukaryotic Translation Initiation Factor 5 Functions as a GTPase-activating Protein* , 2001, The Journal of Biological Chemistry.
[181] T. Aw,et al. Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State , 2001, Molecular and Cellular Biology.
[182] X. Chen,et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. , 2000, Molecular cell.
[183] R. Kaufman,et al. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. , 2000, Genes & development.
[184] M. Schapira,et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. , 2000, Molecular cell.
[185] M. Kim,et al. Cloning of hHRI, Human Heme-regulated Eukaryotic Initiation Factor 2α Kinase: Down-regulated in Epithelial Ovarian Cancers , 2000, Molecules and Cells.
[186] R. Kaufman,et al. Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum* , 2000, The Journal of Biological Chemistry.
[187] Anne Bertolotti,et al. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response , 2000, Nature Cell Biology.
[188] F. Urano,et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. , 2000, Science.
[189] Xiaozhong Wang,et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. , 1998, Genes & development.
[190] A. Helenius,et al. Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum , 1992, Nature.
[191] R. Kaufman,et al. Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[192] A. Dorner,et al. Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells. , 1989, The Journal of biological chemistry.
[193] J. Sambrook,et al. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins , 1988, Nature.
[194] R. Kaufman,et al. The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins , 1987, The Journal of cell biology.
[195] K. Montine,et al. Physiological stresses inhibit guanine-nucleotide-exchange factor in Ehrlich cells. , 1987, European journal of biochemistry.
[196] QingboXu,et al. Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis , 2013 .
[197] H. Heng,et al. Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. , 2012, American journal of translational research.
[198] K. Guan,et al. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis , 2011, Cell Death and Differentiation.
[199] Erin,et al. JNK: A double‐edged sword in tumorigenesis , 2011, Hepatology.
[200] K. Mori,et al. pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation. , 2009, Cell structure and function.
[201] D. Tang,et al. Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. , 2007, The international journal of biochemistry & cell biology.
[202] T. Elliott,et al. Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. , 2002, Immunity.
[203] S. Ochoa,et al. Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2. , 1984, Proceedings of the National Academy of Sciences of the United States of America.