Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.

[1]  L. Oskam,et al.  Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy , 2009, BMC Medical Genetics.

[2]  Lutz Hamann,et al.  Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock , 2009, Proceedings of the National Academy of Sciences.

[3]  T. van der Poll,et al.  Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis) , 2009, Critical care medicine.

[4]  Mauricio Valencia,et al.  Ventilator-associated pneumonia , 2009, Current opinion in critical care.

[5]  R. Salomão,et al.  TLR signaling pathway in patients with sepsis. , 2008, Shock.

[6]  G. Angelini,et al.  Inflammatory response and cardioprotection during open‐heart surgery: the importance of anaesthetics , 2008, British journal of pharmacology.

[7]  R. Medzhitov Recognition of microorganisms and activation of the immune response , 2007, Nature.

[8]  M. Netea,et al.  TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans , 2007, Proceedings of the National Academy of Sciences.

[9]  S. Akira,et al.  Role for MyD88-Independent, TRIF Pathway in Lipid A/TLR4-Induced Endotoxin Tolerance1 , 2007, The Journal of Immunology.

[10]  J. Cavaillon,et al.  Stress molecules in sepsis and systemic inflammatory response syndrome , 2007, FEBS letters.

[11]  Thomas C. Mitchell,et al.  The Vaccine Adjuvant Monophosphoryl Lipid A as a TRIF-Biased Agonist of TLR4 , 2007, Science.

[12]  D. Remick,et al.  Pathophysiology of sepsis. , 2007, The American journal of pathology.

[13]  Giorgio Sirugo,et al.  A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis , 2007, Nature Genetics.

[14]  S. Calvano,et al.  Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). , 2006, Clinical immunology.

[15]  L. Zhao,et al.  A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. , 2006, The Journal of infectious diseases.

[16]  R. Medzhitov,et al.  Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling , 2006, Cell.

[17]  C. Roussos,et al.  Early apoptosis of blood monocytes in the septic host: is it a mechanism of protection in the event of septic shock? , 2006, Critical care.

[18]  S. Bornstein,et al.  Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[19]  S. Akira,et al.  Pathogen Recognition and Innate Immunity , 2006, Cell.

[20]  P. Schlag,et al.  PRE- AND POSTOPERATIVE CYTOKINE RELEASE AFTER IN VITRO WHOLE BLOOD LIPOPOLYSACCHARIDE STIMULATION AND FREQUENT TOLL-LIKE RECEPTOR 4 POLYMORPHISMS , 2006, Shock.

[21]  C. Roussos,et al.  Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis. , 2006, Intensive care medicine.

[22]  S. Zakynthinos,et al.  Does soluble triggering receptor expressed on myeloid cells‐1 play any role in the pathogenesis of septic shock? , 2005, Clinical and experimental immunology.

[23]  E. Abraham,et al.  GENETIC POLYMORPHISMS AND SEPSIS , 2005, Shock.

[24]  L. Jacobs,et al.  Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism. , 2005, Cytokine.

[25]  R. Schumann,et al.  Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. , 2005, The Lancet. Infectious diseases.

[26]  M. David,et al.  INHIBITION OF LIPOPOLYSACCHARIDE-INDUCED INTERFERON REGULATORY FACTOR 3 ACTIVATION AND PROTECTION FROM SEPTIC SHOCK BY HYDROXYSTILBENES , 2004, Shock.

[27]  S. le Cessie,et al.  TNF-alpha promoter, Nod2 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin. , 2004, Cytokine.

[28]  R. Schumann,et al.  Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor -2, -4, and -9 genes. , 2004, Journal of immunological methods.

[29]  T. Albertson,et al.  Genomic polymorphisms in sepsis , 2004, Critical care medicine.

[30]  B. Beutler Innate immunity: an overview. , 2004, Molecular immunology.

[31]  M. Fenton,et al.  TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. , 2003, Molecular interventions.

[32]  K. Walley,et al.  Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy. , 2003, Chest.

[33]  B. Beutler,et al.  Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[34]  M. Netea,et al.  Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing? , 2003, Trends in immunology.

[35]  Mitchell M. Levy,et al.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference , 2003, Intensive Care Medicine.

[36]  S. Msika,et al.  Risk factors for postoperative infectious complications in noncolorectal abdominal surgery: a multivariate analysis based on a prospective multicenter study of 4718 patients. , 2003, Archives of surgery.

[37]  S. Calvano,et al.  Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. , 2002, The Journal of infectious diseases.

[38]  D. Schwartz,et al.  Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. , 2002, Archives of internal medicine.

[39]  A. Waage,et al.  Inflammatory Response After Open Heart Surgery: Release of Heat-Shock Protein 70 and Signaling Through Toll-Like Receptor-4 , 2002, Circulation.

[40]  Dirk E. Smith,et al.  Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction , 2001, Nature.

[41]  C. Cannings,et al.  A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. , 2001, The Journal of infectious diseases.

[42]  D. Schwartz,et al.  Determination of the TLR4 genotype using allele-specific PCR. , 2001, BioTechniques.

[43]  J. Parrillo Pathogenetic mechanisms of septic shock. , 1993, The New England journal of medicine.

[44]  P. Andersen,et al.  Genetic and environmental influences on premature death in adult adoptees. , 1988, The New England journal of medicine.

[45]  M. McCarron,et al.  Septic Shock , 1964, International anesthesiology clinics.

[46]  戴生明 “proinflammatory cytokines”不宜翻译为“前炎症细胞因子” , 2010 .