Properties of guinea pig 7S antibodies. II. Identification of antibodies involved in passive cutaneous and systemic anaphylaxis.

Guinea pig 7Sγ1 antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ2 antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sγ2 antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites.

[1]  B. Benacerraf,et al.  Properties of guinea pig 7S antibodies. I. Electrophoretic separation of two types of guinea pig 7S antibodies. , 1963, The Journal of experimental medicine.

[2]  B. Benacerraf,et al.  PROPERTIES OF GUINEA PIG 7S ANTIBODIES III. IDENTIFICATION OF ANTIBODIES INVOLVED IN COMPLEMENT FIXATION AND HEMOLYSIS , 1963 .

[3]  J. Coe,et al.  THE SPECIFICITY OF ALLERGIC REACTIONS , 1962, The Journal of experimental medicine.

[4]  G. Edelman,et al.  On structural and functional relations between antibodies and proteins of the gamma-system. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[5]  G. Edelman,et al.  Structural differences among antibodies of different specificities. , 1961, Proceedings of the National Academy of Sciences of the United States of America.

[6]  F. Karush,et al.  Studies on the immunologic mechanism of anaphylaxis. II. Sensitizing and combining capacity in vivo of fractions separated from papain digests of antihapten antibody. , 1961, Journal of immunology.

[7]  R. F. Smith,et al.  The specificity of allergic reactions. I. Delayed versus Arthus hypersensitivity. , 1960 .

[8]  Z. Óváry.  Reverse passive cutaneous anaphylaxis in the guinea pig with horse, sheep or hen antibodies. , 1960, Immunology.

[9]  A. G. Osler,et al.  STUDIES ON THE MECHANISM OF HYPERSENSITIVITY PHENOMENA III. THE PARTICIPATION OF COMPLEMENT IN THE FORMATION OF ANAPHYLATOXIN , 1959 .

[10]  A. Fletcher,et al.  xi-Aminocaproic acid: an inhibitor of plasminogen activation. , 1959, The Journal of biological chemistry.

[11]  R. Binaghi,et al.  The competitive effect of normal serum proteins from various animal species on antibody fixation in passive cutaneous anaphylaxis in the guinea pig. , 1959, Journal of immunology.

[12]  Z. Óváry.  Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction. , 1958, Progress in allergy.

[13]  A. G. Osler,et al.  Studies on the mechanism of hypersensitivity phenomena. II. The participation of complement in passive cutaneous anaphylaxis of the albino rat. , 1957 .

[14]  A. G. Osler,et al.  STUDIES ON THE MECHANISM OF HYPERSENSITIVITY PHENOMENA , 1957, The Journal of experimental medicine.

[15]  O. Bier,et al.  Quantitative studies on passive cutaneous anaphylaxis in the guinea pig and its relationship to the Arthus phenomenon. , 1953, Journal of immunology.

[16]  J. Cann,et al.  Distribution of allergic and blocking activity in human serum proteins fractionated by electrophoresis convection. , 1953, Science.

[17]  E. Kabat,et al.  A quantitative study of passive anaphylaxis in the guinea pig. , 1942, Journal of immunology.