Epidural infusion of low‐dose bupivacaine and opioid in labour Does reducing motor block increase the spontaneous delivery rate?

Labouring women were randomly allocated to receive epidural infusions during labour of either 0.125% plain bupivacaine (n = 200) or a combination of 0.0625% bupivacaine with either 2.5μg.ml‐1 fentanyl or 0.25μg.ml‐1 sufentanil (n = 199) each starting at 12 ml.h‐1 and adjusted as necessary to maintain analgesia. The dose of bupivacaine, both hourly (p < 0.001) and total (p < 0.001), was significantly lower in the group receiving the combination. Motor block was significantly less common and less severe in the combination group (p < 0.001). These reductions did not result in a significant increase in spontaneous deliveries. Maternal satisfaction with first (p < 0.001) and second stage analgesia (p < 0.001) was significantly increased in the combination group. The addition of opioid to the epidural infusion did not reduce the incidence of perineal pain. There were no significant differences between the groups in neonatal outcome or the incidence of early postnatal symptoms.

[1]  D. Davies,et al.  Randomised comparison of combined spinal-epidural and standard epidural analgesia in labour , 1995, The Lancet.

[2]  J. Quinlan,et al.  Motor block during epidural infusions for nulliparous women in labour: a randomized double-blind study of plain bupivacaine and low dose bupivacaine with fentanyl. , 1995, International journal of obstetric anesthesia.

[3]  P. Popham,et al.  Low dose bupivacaine/fentanyl epidural infusions in labour and mode of delivery , 1994, Anaesthesia.

[4]  R. Russell,et al.  Epidural infusions for nulliparous women in labour , 1993, Anaesthesia.

[5]  R. Russell,et al.  Is opioid loading necessary before opioid/local anaesthetic epidural infusion? A randomized double-blind study in labour. , 1993, International journal of obstetric anesthesia.

[6]  D. Quance Epidural and spinal blockade in obstetrics Felicity Reynolds (Ed.) , 1991 .

[7]  P. Banfield,et al.  Epidural analgesia and maternal satisfaction. , 1991, BMJ.

[8]  A. van Assche,et al.  The effects of the addition of sufentanil to 0.125% bupivacaine on the quality of analgesia during labor and on the incidence of instrumental deliveries. , 1991, Anesthesiology.

[9]  A. Stein Epidural analgesia and maternal satisfaction , 1991, BMJ.

[10]  G. Cooper,et al.  Bupivacaine versus bupivacaine plus fentanyl for epidural analgesia: effect on maternal satisfaction. , 1991, BMJ.

[11]  T. Abboud,et al.  Continuous Infusion Epidural Anesthesia during Labor: A Randomized, Double-blind Comparison of 0.0625% Bupivacaine/0.002% Butorphanol and 0.125% Bupivacaine , 1990, Regional Anesthesia & Pain Medicine.

[12]  N. Manago,et al.  Continuous epidural infusion of 0.0625% bupivacaine-0.0002% fentanyl during the second stage of labor. , 1990, Anesthesiology.

[13]  F. Reynolds,et al.  Epidural fentanyl and perineal pain in labour , 1989, Anaesthesia.

[14]  D. Chestnut,et al.  Continuous Infusion Epidural Analgesia during Labor: A Randomized, Double‐blind Comparison of 0.0625% Bupivacaine / 0.0002% Fentanyl Versus 0.125% Bupivacaine , 1988, Anesthesiology.

[15]  G. Phillips Continuous Infusion Epidural Analgesia in Labor: The Effect of Adding Sufentanil to 0.125% Bupivacaine , 1988, Anesthesia and analgesia.

[16]  G. Phillips Continuous infusion epidural analgesia in labor: the effect of adding sufentanil to 0.125% bupivacaine. , 1988 .

[17]  D. Bogod,et al.  Extradural Infusion of 0.125% Bupivacaine at 10 ml/h to Women During Labour , 1987 .

[18]  D. Murphy,et al.  Measurement of Pain: A Comparison of the Visual Analogue with a Nonvisual Analogue Scale , 1987 .

[19]  D. Bogod,et al.  Extradural infusion of 0.125% bupivacaine at 10 ml h-1 to women during labour. , 1987, British journal of anaesthesia.

[20]  M. Tunstall,et al.  Continuous infusion epidural analgesia in obstetrics , 1986, Anaesthesia.

[21]  M. Tunstall,et al.  Continuous infusion epidural analgesia in obstetrics , 1986, Anaesthesia.

[22]  M. Rosen,et al.  Continuous extradural infusion of 0.0625% or 0.125% bupivacaine for pain relief in primigravid labour. , 1985, British journal of anaesthesia.

[23]  M. Soetens,et al.  Measuring Motor Block During Lumbar Epidural Analgesia for Vaginal Delivery , 1984 .

[24]  C. Bulpitt,et al.  Analgesia and Satisfaction in Childbirth (The Queen Charlotte??s 1000 Mother Survey) , 1983 .

[25]  C. Bulpitt,et al.  ANALGESIA AND SATISFACTION IN CHILDBIRTH (THE QUEEN CHARLOTTE'S 1000 MOTHER SURVEY) , 1982, The Lancet.

[26]  G Barrier,et al.  A New Neurologic and Adaptive Capacity Scoring System for: Evaluating Obstetric Medications in Full‐term Newborns , 1982, Anesthesiology.

[27]  C. Amiel‐Tison,et al.  A NEW NEUROLOGIC AND ADAPTIVE CAPACITY SCORING SYSTEM FOR EVALUATING OBSTETRIC MEDICATIONS IN FULL-TERM NEWBORNS , 1980 .

[28]  L. Carrie,et al.  Continuous epidural infusion of bupivacaine in labour , 1979, Anaesthesia.

[29]  L. Carrie,et al.  Continuous epidural infusion of bupivacaine in labour , 1979, Anaesthesia.

[30]  C. Bailey,et al.  Diamorphine-bupivacaine mixture compared with plain bupivacaine for analgesia. , 1994, British journal of anaesthesia.

[31]  J. S. Crawford Lumbar epidural block in labour: a clinical analysis. , 1972, British journal of anaesthesia.