Goodpasture Syndrome (Anti-glomerular Basement Membrane Antibody Disease)

Goodpasture syndrome refers to an anti-glomerular basement membrane (anti-GBM) disease that involves both the lungs and kidneys, often presenting as pulmonary hemorrhage and glomerulonephritis. However, some clinicians may use several terms interchangeably, including anti-glomerular basement membrane disease, Goodpasture syndrome, and Goodpasture disease. [1]The latter is the most specific term, and refers to the presence of renal and pulmonary involvement, along with anti-glomerular basement membrane antibodies. The spectrum of disease may present classically or as glomerulonephritis alone.