Use of laser diffraction spectroscopy for measuring size distribution of human thrombocytes

ConclusionThe method of laser diffraction spectroscopy can be used in studies of human thrombocyte size. The method allows the size distribution of thrombocytes, the width of the distribution, and the extinction coefficient of thrombocytes to be determined. It is anticipated that detection of changes in the extinction coefficient of thrombocytes during various processes, such as aggregation of cells and reaction of release, can provide information about changes in the morphology of thrombocytes. It is also expected that this information could provide a new insight into certain intracellular processes correlated with changes in the structure of cytoskeleton, modification of cellular organelles, etc.