Superior therapeutic activity of TGF-β-induced extracellular vesicles against interstitial cystitis.

[1]  Ssang-Goo Cho,et al.  New therapeutic approach with extracellular vesicles from stem cells for interstitial cystitis/bladder pain syndrome , 2022, BMB reports.

[2]  Kyung Min Lim,et al.  High Therapeutic and Esthetic Properties of Extracellular Vesicles Produced from the Stem Cells and Their Spheroids Cultured from Ocular Surgery-Derived Waste Orbicularis Oculi Muscle Tissues , 2021, Antioxidants.

[3]  C. Jorgensen,et al.  Mesenchymal Stem Cell-Derived Extracellular Vesicles: Opportunities and Challenges for Clinical Translation , 2020, Frontiers in Bioengineering and Biotechnology.

[4]  Nadia J. T. Roumans,et al.  Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells. , 2020, Biomaterials.

[5]  Zhengpin Liu,et al.  TGF-β1-containing exosomes derived from bone marrow mesenchymal stem cells promote proliferation, migration and fibrotic activity in rotator cuff tenocytes , 2020, Regenerative therapy.

[6]  Kyung Min Lim,et al.  Bioinformatics Approach for Identifying Novel Biomarkers and Their Signaling Pathways Involved in Interstitial Cystitis/Bladder Pain Syndrome with Hunner Lesion , 2020, Journal of clinical medicine.

[7]  S. Soper,et al.  Isolation and analysis methods of extracellular vesicles (EVs) , 2020, Extracellular vesicles and circulating nucleic acids.

[8]  S. Chand,et al.  Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications , 2020, Frontiers in Cell and Developmental Biology.

[9]  Ssang-Goo Cho,et al.  Application of Adult and Pluripotent Stem Cells in Interstitial Cystitis/Bladder Pain Syndrome Therapy: Methods and Perspectives , 2020, Journal of clinical medicine.

[10]  Dong-Myung Shin,et al.  Current and Future Directions of Stem Cell Therapy for Bladder Dysfunction , 2019, Stem Cell Reviews and Reports.

[11]  T. Whiteside,et al.  Challenges in Exosome Isolation and Analysis in Health and Disease , 2019, International journal of molecular sciences.

[12]  J. Lötvall,et al.  Endosomal signalling via exosome surface TGFβ-1 , 2019, Journal of extracellular vesicles.

[13]  S. Kwon.  Extracellular vesicles in renal physiology and clinical applications for renal disease , 2019, The Korean journal of internal medicine.

[14]  C. Yee,et al.  Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities , 2019, Breast Cancer Research.

[15]  M. DiFiglia,et al.  Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity. , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

[16]  Jing Xu,et al.  Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines , 2018, Journal of Extracellular Vesicles.

[17]  T. Ochiya,et al.  Clinical Application of Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapeutics for Inflammatory Lung Diseases , 2018, Journal of clinical medicine.

[18]  Z. Xin,et al.  Exosomes derived from mesenchymal stem cells exert therapeutic effect in a rat model of cavernous nerves injury , 2018, Andrology.

[19]  B. Min,et al.  Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells , 2018, Tissue Engineering and Regenerative Medicine.

[20]  H. Byrne,et al.  Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death , 2018, Scientific Reports.

[21]  M. Ghahremani,et al.  Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine , 2018, Stem Cell Research & Therapy.

[22]  R. Krams,et al.  New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress , 2018 .

[23]  Eun Hee Kim,et al.  Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells , 2018, Scientific Reports.

[24]  S. Chun,et al.  Comparison of 5 Different Rat Models to Establish a Standard Animal Model for Research Into Interstitial Cystitis , 2017, International neurourology journal.

[25]  Dong-Myung Shin,et al.  Histopathological characteristics of interstitial cystitis/bladder pain syndrome without Hunner lesion , 2017, Histopathology.

[26]  Dong-Myung Shin,et al.  Improved efficacy and in vivo cellular properties of human embryonic stem cell derivative in a preclinical model of bladder pain syndrome , 2017, Scientific Reports.

[27]  Bernd Giebel,et al.  Concise Review: Developing Best‐Practice Models for the Therapeutic Use of Extracellular Vesicles , 2017, Stem cells translational medicine.

[28]  Xiao-Fan Wang,et al.  TGF-β Family Signaling in the Control of Cell Proliferation and Survival. , 2017, Cold Spring Harbor perspectives in biology.

[29]  M. Pittenger,et al.  Concise Review: MSC‐Derived Exosomes for Cell‐Free Therapy , 2017, Stem cells.

[30]  Z. Balsara,et al.  Sleeping beauty: awakening urothelium from its slumber. , 2017, American journal of physiology. Renal physiology.

[31]  Jaesung Park,et al.  Methods to isolate extracellular vesicles for diagnosis , 2017 .

[32]  A. Didangelos,et al.  The Expression of Inflammatory Mediators in Bladder Pain Syndrome , 2016, European urology.

[33]  A. Cianciulli,et al.  PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia. , 2016, International immunopharmacology.

[34]  Thomas Ritter,et al.  Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

[35]  Yuan-Hong Jiang,et al.  Alteration of Urothelial Inflammation, Apoptosis, and Junction Protein in Patients with Various Bladder Conditions and Storage Bladder Symptoms Suggest Common Pathway Involved in Underlying Pathophysiology , 2015, Lower urinary tract symptoms.

[36]  L. O’Driscoll,et al.  Biological properties of extracellular vesicles and their physiological functions , 2015, Journal of extracellular vesicles.

[37]  M. Fall,et al.  Cytokine expression in patients with bladder pain syndrome/interstitial cystitis ESSIC type 3C. , 2014, The Journal of urology.

[38]  A. Falus,et al.  Emerging role of extracellular vesicles in inflammatory diseases , 2014, Nature Reviews Rheumatology.

[39]  Eric J. Gonzalez,et al.  The Role(s) of Cytokines/Chemokines in Urinary Bladder Inflammation and Dysfunction , 2014, BioMed research international.

[40]  Yong Song Gho,et al.  Importance of exosome depletion protocols to eliminate functional and RNA-containing extracellular vesicles from fetal bovine serum , 2014, Journal of extracellular vesicles.

[41]  P. ten Dijke,et al.  Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer. , 2013, Trends in biochemical sciences.

[42]  T. Walshe,et al.  The Role of Shear-Induced Transforming Growth Factor-&bgr; Signaling in the Endothelium , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[43]  G. Camussi,et al.  Role of stem-cell-derived microvesicles in the paracrine action of stem cells. , 2013, Biochemical Society transactions.

[44]  D. Peterson,et al.  Human Mesenchymal Stem Cell Grafts Enhance Normal and Impaired Wound Healing by Recruiting Existing Endogenous Tissue Stem/Progenitor Cells , 2013, Stem cells translational medicine.

[45]  R. Schiffelers,et al.  Microvesicles and exosomes: opportunities for cell-derived membrane vesicles in drug delivery. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[46]  H. Kuo,et al.  Higher levels of cell apoptosis and abnormal E‐cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis/painful bladder syndrome , 2011, BJU international.

[47]  Harihara Baskaran,et al.  Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals , 2011, Current Biology.

[48]  C. Parsons.  The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain , 2011, BJU international.

[49]  A. Tewari,et al.  Role of inflammation in bladder function and interstitial cystitis , 2011, Therapeutic advances in urology.

[50]  M. Pontari,et al.  Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. , 2010, The Journal of urology.

[51]  Xue-Ru Wu,et al.  Uroplakins in urothelial biology, function, and disease. , 2009, Kidney international.

[52]  G. Sant,et al.  The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. , 2007, Urology.

[53]  E. Ustinova,et al.  Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization. , 2006, American journal of physiology. Renal physiology.

[54]  Fang-Ming Deng,et al.  Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability. , 2002, American journal of physiology. Renal physiology.

[55]  T. Gjøen,et al.  Effect of Temperature on Endocytosis and Intracellular Transport in the Cell Line SHK-1 Derived from Salmon Head Kidney , 1997 .

[56]  Dong-Myung Shin,et al.  Ascorbic acid 2-glucoside stably promotes the primitiveness of embryonic and mesenchymal stem cells through TET- and CREB1-dependent mechanisms. , 2019, Antioxidants & redox signaling.

[57]  Dong-Myung Shin,et al.  Stem Cell Therapy for Interstitial Cystitis/Bladder Pain Syndrome , 2015, Current Urology Reports.

[58]  Richard J Simpson,et al.  A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. , 2015, Methods in molecular biology.