Adding herbal extracts to silicone gel on post-sternotomy scar: a prospective randomised double-blind study.

OBJECTIVE Silicone gel has been shown effective in improving healing post-sternotomy scars. It remains to be determined whether adding herbal extracts to the gel would augment the healing effect. METHOD After median sternotomy, patients were randomised into two groups. Group 1: topical silicone gel plus herbal extract gel (Allium cepa, Centella Asiatica, Aloe vera and Paper Mulberry) and Group 2: silicone gel. Patients were treated for six months. The postoperative scars were assessed at three and six months by plastic surgeons using the Vancouver Scar Scale (VSS) and the patient assessment scar scale. RESULTS Each group comprised 23 patients (n=46 in total). The VSS was significantly lower in Group 1 than in Group 2 (p=0.018 and p=0.051, respectively). In Group 1, the four differences from baseline were vascularity scores at three and six months (-0.391, p=0.025; -0.435, p=0.013, respectively), and pigmentation scores at three and six months (-0.391, p=0.019; -0.609, p=0.000, respectively). In Group 2, differences from baseline were the pigmentation and vascularity score at six months (-0.6609, p=0.000; -0.348, p=0.046, respectively). CONCLUSION Our results suggest, post-sternotomy scars trend to have better vascularity and pigmentation when treated with silicone gel plus herbal extracts.

[1]  D. Rahayu,et al.  Formulation of Antioxidant Gel from Black Mulberry Fruit Extract (Morus nigra L.) , 2019, Journal of pharmacy & bioallied sciences.

[2]  R. Ogawa,et al.  Objective Spectrometric Measurement of Keloid Color in the East Asian Population: Pitfalls of Subjective Color Measurements. , 2016, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

[3]  B. Hwang,et al.  Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology , 2015, Molecules.

[4]  Tarek M. Fakhouri,et al.  Scar prevention and remodeling: a review of the medical, surgical, topical and light treatment approaches , 2014, International journal of dermatology.

[5]  Daegu Son,et al.  Overview of Surgical Scar Prevention and Management , 2014, Journal of Korean medical science.

[6]  A. Chuangsuwanich,et al.  The Efficacy of Combined Herbal Extracts Gel in Reducing Scar Development at a Split-Thickness Skin Graft Donor Site , 2013, Aesthetic Plastic Surgery.

[7]  C. Kuptarnond,et al.  Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial , 2012, International wound journal.

[8]  V. Gabriel,et al.  Hypertrophic scar. , 2011, Physical medicine and rehabilitation clinics of North America.

[9]  O. P. Mushin,et al.  Silicone-Based Scar Therapy: A Review of the Literature , 2010, Aesthetic Plastic Surgery.

[10]  E. Swennen,et al.  In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers. , 2008, Nutrition.

[11]  F. Lacarrubba,et al.  An open‐label pilot study to evaluate the efficacy and tolerability of a silicone gel in the treatment of hypertrophic scars using clinical and ultrasound assessments , 2008, The Journal of dermatological treatment.

[12]  Thomas A. Mustoe, MD, FACS Evolution of Silicone Therapy and Mechanism of Action in Scar Management , 2007, Aesthetic Plastic Surgery.

[13]  B. Atiyeh,et al.  Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods , 2020, Aesthetic Plastic Surgery.

[14]  C. Li-Tsang,et al.  A prospective randomized clinical trial to investigate the effect of silicone gel sheeting (Cica-Care) on post-traumatic hypertrophic scar among the Chinese population. , 2006, Burns : journal of the International Society for Burn Injuries.

[15]  Chetwyn C H Chan,et al.  Prevalence of hypertrophic scar formation and its characteristics among the Chinese population. , 2005, Burns : journal of the International Society for Burn Injuries.

[16]  T. Gilman Silicone sheet for treatment and prevention of hypertrophic scar: a new proposal for the mechanism of efficacy , 2003, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[17]  H. Huynh,et al.  Suppression of insulin‐like growth factor signalling pathway and collagen expression in keloid‐derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids , 2003, The British journal of dermatology.

[18]  Hiko Hyakusoku,et al.  Postoperative Electron‐Beam Irradiation Therapy for Keloids and Hypertrophic Scars: Retrospective Study of 147 Cases Followed for More Than 18 Months , 2003, Plastic and reconstructive surgery.

[19]  Thomas A. Mustoe, MD, FACS,et al.  Effect of Mederma on hypertrophic scarring in the rabbit ear model. , 2002, Plastic and reconstructive surgery.

[20]  M. Kon,et al.  The Use of Silicone Occlusive Sheeting (Sil‐K) and Silicone Occlusive Gel (Epiderm) in the Prevention of Hypertrophic Scar Formation , 1998, Plastic and reconstructive surgery.

[21]  B. Escalante,et al.  Antiinflammatory activity of extracts from Aloe vera gel. , 1996, Journal of ethnopharmacology.

[22]  R. Roberts,et al.  Hypertrophic Sternal Scars: Silicone Gel Sheet versus Kenalog Injection Treatment , 1992, Plastic and reconstructive surgery.

[23]  K. Sone,et al.  Treatment of scars and keloids with a cream containing silicone oil. , 1990, British journal of plastic surgery.