Chronic Stress, Genetic Risk, and Obesity in US Hispanic/Latinos: Results From the Hispanic Community Health Study/Study of Latinos

ABSTRACT Objective This study aimed to investigate whether the association of chronic stress with obesity is independent of genetic risk and test whether it varies by the underlying genetic risk. Methods The analysis included data from the Hispanic Community Health Study/Study of Latinos, a community-based study of Hispanic/Latinos living in four US communities (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). The sample consisted of 5336 women and 3231 men who attended the Hispanic Community Health Study/Study of Latinos second in-person examination, had measures of obesity, and chronic stress, and were genotyped. Chronic stress burden was assessed by an eight-item scale. An overall polygenic risk score was calculated based on the summary statistics from GIANT and UK BioBank meta-analysis of body mass index (BMI) genome-wide association studies. Mixed-effect models were used to account for genetic relatedness and sampling design, as well as to adjust for potential confounders. Results A higher number of chronic stressors were associated with both BMI (β [log odds] = 0.31 [95% confidence interval = 0.23–0.38]) and obesity (β [log odds] = 0.10 [95% confidence interval = 0.07–0.13]), after adjustment for covariates and genetic risk. No interactions were found between chronic stress and the genetic risk score for BMI or obesity. Conclusions We did not find evidence for an interaction between chronic stress and polygenic risk score, which was not consistent with other publications that showed greater BMI or obesity in the groups with high stressors and elevated genetic risk.

[1]  Henry J. Lin,et al.  Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes , 2021, medRxiv.

[2]  M. Lamar,et al.  Physical activity, stress, and cardiovascular disease risk: HCHS/SOL Sociocultural Ancillary Study , 2020, Preventive medicine reports.

[3]  M. Sliwinski,et al.  Stress is Associated with Neurocognitive Function in Hispanic/Latino Adults: Results from HCHS/SOL Socio-Cultural Ancillary Study. , 2019, The journals of gerontology. Series B, Psychological sciences and social sciences.

[4]  J. Bjørngaard,et al.  Quantifying the impact of genes on body mass index during the obesity epidemic: longitudinal findings from the HUNT Study , 2019, BMJ.

[5]  Shing Wan Choi,et al.  PRSice-2: Polygenic Risk Score software for biobank-scale data , 2019, GigaScience.

[6]  Marcelo P. Segura-Lepe,et al.  Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity , 2019, Nature Genetics.

[7]  Ian J. Deary,et al.  Sex-specific moderation by lifestyle and psychosocial factors on the genetic contributions to adiposity in 112,151 individuals from UK Biobank , 2019, Scientific Reports.

[8]  Ying Sun,et al.  Polygenic differential susceptibility to cumulative stress exposure and childhood obesity , 2018, International Journal of Obesity.

[9]  P. Visscher,et al.  Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry , 2018, bioRxiv.

[10]  T. Sofer,et al.  Objectively Measured Physical Activity, Sedentary Behavior, and Genetic Predisposition to Obesity in U.S. Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) , 2017, Diabetes.

[11]  S. Kardia,et al.  Interaction between Social/Psychosocial Factors and Genetic Variants on Body Mass Index: A Gene-Environment Interaction Analysis in a Longitudinal Setting , 2017, International journal of environmental research and public health.

[12]  M. Rask-Andersen,et al.  Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status , 2017, PLoS genetics.

[13]  S. Redline,et al.  Stress and sleep: Results from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study , 2017, SSM - population health.

[14]  Kyoung-Bok Min,et al.  Interaction between the RGS6 gene and psychosocial stress on obesity-related traits. , 2017, Endocrine journal.

[15]  Stéphane Joost,et al.  Gene–obesogenic environment interactions in the UK Biobank study , 2017, International journal of epidemiology.

[16]  S. Marshall,et al.  The Role of Stress in Understanding Differences in Sedentary Behavior in Hispanic/Latino Adults: Results From the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study. , 2016, Journal of physical activity & health.

[17]  Ryung S. Kim,et al.  Association of Childhood Economic Hardship with Adult Height and Adult Adiposity among Hispanics/Latinos. The HCHS/SOL Socio-Cultural Ancillary Study , 2016, PLoS ONE.

[18]  Kathleen F. Kerr,et al.  Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. , 2016, American journal of human genetics.

[19]  N. Schneiderman,et al.  Objectively Measured Sedentary Time and Cardiometabolic Biomarkers in US Hispanic/Latino Adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL). , 2015, Circulation.

[20]  N. Schneiderman,et al.  Chronic stress, inflammation, and glucose regulation in U.S. Hispanics from the HCHS/SOL Sociocultural Ancillary Study. , 2015, Psychophysiology.

[21]  Toshiko Tanaka,et al.  Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry , 2015, Human molecular genetics.

[22]  S. Marshall,et al.  Accelerometer adherence and performance in a cohort study of US Hispanic adults. , 2015, Medicine and science in sports and exercise.

[23]  N. Schneiderman,et al.  Is Acculturation Related to Obesity in Hispanic/Latino Adults? Results from the Hispanic Community Health Study/Study of Latinos , 2015, Journal of obesity.

[24]  N. Schneiderman,et al.  Psychosocial stress is associated with obesity and diet quality in Hispanic/Latino adults. , 2015, Annals of epidemiology.

[25]  W. Kraus,et al.  Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene , 2014, European Journal of Human Genetics.

[26]  Jianwen Cai,et al.  Body Mass Index, Sex, and Cardiovascular Disease Risk Factors Among Hispanic/Latino Adults: Hispanic Community Health Study/Study of Latinos , 2014, Journal of the American Heart Association.

[27]  N. Schneiderman,et al.  Associations of Chronic Stress Burden, Perceived Stress, and Traumatic Stress With Cardiovascular Disease Prevalence and Risk Factors in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study , 2014, Psychosomatic medicine.

[28]  Leena Choi,et al.  Validation of accelerometer wear and nonwear time classification algorithm. , 2011, Medicine and science in sports and exercise.

[29]  John P Elder,et al.  Sample design and cohort selection in the Hispanic Community Health Study/Study of Latinos. , 2010, Annals of epidemiology.

[30]  Lloyd E Chambless,et al.  Design and implementation of the Hispanic Community Health Study/Study of Latinos. , 2010, Annals of epidemiology.

[31]  S. Goodwin,et al.  The Practical Guide to the Identification, Evaluation and Treatment of Overweight and Obesity in Adults , 2002 .

[32]  K. Matthews,et al.  A longitudinal study of the effects of pessimism, trait anxiety, and life stress on depressive symptoms in middle-aged women. , 1996, Psychology and aging.

[33]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[34]  R. Shephard.  Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study , 2011 .