Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib
暂无分享,去创建一个
Steven H. Liang | G. El Fakhri | U. Mahmood | D. Wooten | M. Normandin | N. Vasdev | R. Waterhouse | E. Livni | M. Stabin | K. Maresca | Jianqing Chen | T. Collier | Nickeisha A Stephenson | S. Esfahani | Wei Wang | Paul G. Richardson | Nickeisha A. Stephenson | Paul Richardson | Shadi A Esfahani
[1] Lauren L. Ritterhouse,et al. Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer. , 2016, Cancer discovery.
[2] Lauren L. Ritterhouse,et al. Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer , 2016 .
[3] Steven H. Liang,et al. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. , 2016, Angewandte Chemie.
[4] D. Costa. ALK inhibitors: plateauing systemic and intracranial activity? , 2016, The Lancet Oncology.
[5] D. Costa,et al. Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches , 2016, Therapeutic advances in respiratory disease.
[6] Steven H. Liang,et al. Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(iii) ylides , 2016, Chemical science.
[7] N. Sach,et al. Conformational Studies and Atropisomerism Kinetics of the ALK Clinical Candidate Lorlatinib (PF-06463922) and Desmethyl Congeners. , 2016, Angewandte Chemie.
[8] D. Planchard,et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments , 2016, Therapeutic advances in medical oncology.
[9] R. Schirrmacher,et al. Recent Advances in the Development and Application of Radiolabeled Kinase Inhibitors for PET Imaging , 2015, Molecules.
[10] Akira Inoue,et al. Brain Metastases in NSCLC - are TKIs Changing the Treatment Strategy? , 2015, Anticancer research.
[11] K. Varnäs,et al. Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. , 2015, Journal of medicinal chemistry.
[12] C. Lovly,et al. Anaplastic Lymphoma Kinase as a Therapeutic Target in Non–Small Cell Lung Cancer , 2015, Cancer journal.
[13] Shibing Deng,et al. PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models. , 2015, Cancer cell.
[14] G. Toyokawa,et al. Updated Evidence on the Mechanisms of Resistance to ALK Inhibitors and Strategies to Overcome Such Resistance: Clinical and Preclinical Data , 2015, Oncology Research and Treatment.
[15] M. McTigue,et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations , 2015, Proceedings of the National Academy of Sciences.
[16] Steven H. Liang,et al. Iodonium Ylide–Mediated Radiofluorination of 18F-FPEB and Validation for Human Use , 2015, The Journal of Nuclear Medicine.
[17] V. Mittal,et al. Novel ALK inhibitors in clinical use and development , 2015, Journal of Hematology & Oncology.
[18] S. Ou,et al. Anaplastic lymphoma kinase inhibitors in brain metastases from ALK+ non-small cell lung cancer: hitting the target even in the CNS. , 2015, Chinese clinical oncology.
[19] Meining Wang,et al. Alectinib: a novel second generation anaplastic lymphoma kinase (ALK) inhibitor for overcoming clinically-acquired resistance , 2015, Acta pharmaceutica Sinica. B.
[20] S. Yamazaki,et al. Pharmacodynamic Relationships in Nonclinical Tumor Models: A Case Study of Orally Available Novel Inhibitors of Anaplastic Lymphoma Kinase AUTHORS: , 2014 .
[21] Andrei K. Yudin,et al. Macrocycles: lessons from the distant past, recent developments, and future directions , 2014, Chemical science.
[22] Giancarlo Pascali,et al. Optimization of nucleophilic 18F radiofluorinations using a microfluidic reaction approach , 2014, Nature Protocols.
[23] M. Ceccon. Ceritinib as a promising therapy for ALK related diseases. , 2014, Translational lung cancer research.
[24] Wei Liu,et al. Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain expos , 2014, Journal of medicinal chemistry.
[25] Huichun Zhu,et al. Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant , 2014 .
[26] Steven H. Liang,et al. Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics , 2014, Nature Communications.
[27] Steven H. Liang,et al. Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque. , 2014, Journal of labelled compounds & radiopharmaceuticals.
[28] R. Pazdur,et al. U.S. Food and Drug Administration Approval: Crizotinib for Treatment of Advanced or Metastatic Non–Small Cell Lung Cancer That Is Anaplastic Lymphoma Kinase Positive , 2014, Clinical Cancer Research.
[29] H. Ohno,et al. Variant translocation partners of the anaplastic lymphoma kinase (ALK) gene in two cases of anaplastic large cell lymphoma, identified by inverse cDNA polymerase chain reaction. , 2014, Journal of clinical and experimental hematopathology : JCEH.
[30] P. Cumming,et al. PET radiopharmaceuticals for probing enzymes in the brain. , 2013, American journal of nuclear medicine and molecular imaging.
[31] F. Hirsch,et al. The role of anaplastic lymphoma kinase inhibitors in the treatment of advanced nonsmall cell lung cancer , 2013, Current opinion in oncology.
[32] W. Wadsak,et al. Radiolabeling of [18F]altanserin - a microfluidic approach. , 2012, Nuclear medicine and biology.
[33] P. Cumming,et al. PET of Signal Transduction Pathways in Cancer , 2012, The Journal of Nuclear Medicine.
[34] Robert B. Innis,et al. Suggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies , 2011, European Journal of Nuclear Medicine and Molecular Imaging.
[35] J. Llop,et al. Fully automated and reproducible radiosynthesis of high specific activity [11C]raclopride and [11C]Pittsburgh compound-B using the combination of two commercial synthesizers , 2011, Nuclear medicine communications.
[36] W. Wadsak,et al. Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB). , 2011, Applied Radiation and Isotopes.
[37] S. Kobayashi,et al. CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[38] Alan A. Wilson,et al. Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT , 2010, Molecules.
[39] F. Kelleher,et al. The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene. , 2010, European journal of cancer.
[40] Petr Znamenskiy,et al. Behavioral and Neurochemical Alterations in Mice Deficient in Anaplastic Lymphoma Kinase Suggest Therapeutic Potential for Psychiatric Indications , 2008, Neuropsychopharmacology.
[41] Michael G Stabin,et al. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[42] Michael G Stabin,et al. PHYSICAL MODELS AND DOSE FACTORS FOR USE IN INTERNAL DOSE ASSESSMENT , 2003, Health physics.
[43] Matthew J. McAuliffe,et al. Medical Image Processing, Analysis and Visualization in clinical research , 2001, Proceedings 14th IEEE Symposium on Computer-Based Medical Systems. CBMS 2001.
[44] J. Chan,et al. TIMELY TOPIC: ANAPLASTIC LYMPHOMA KINASE (ALK) SPREADS ITS INFLUENCE , 2001, Pathology.
[45] Alan A. Wilson,et al. Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method. , 2000, Nuclear medicine and biology.
[46] D M Foster,et al. Developing and testing integrated multicompartment models to describe a single-input multiple-output study using the SAAM II software system. , 1998, Advances in experimental medicine and biology.
[47] L. Deady,et al. Relative rates of N-methylation of o-substituted pyridines. Steric and electronic effects , 1972 .