Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects

[1]  J. Levy,et al.  Immunoradiometric assay of insulin, intact proinsulin and 32–33 split proinsulin and radioimmunoassay of insulin in diet-treated Type 2 (non-insulin-dependent) diabetic subjects , 1992, Diabetologia.

[2]  Y. Iwamoto,et al.  Serum proinsulin levels at fasting and after oral glucose load in patients with Type 2 (non-insulin-dependent) diabetes mellitus , 1988, Diabetologia.

[3]  Y. Iwamoto,et al.  Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance , 1991, Diabetologia.

[4]  P. Arner,et al.  Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects , 1991, Diabetologia.

[5]  D. Porte,et al.  Disproportionate elevation of immunoreactive proinsulin in Type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance , 1987, Diabetologia.

[6]  E. Ravussin,et al.  Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. , 1993, The New England journal of medicine.

[7]  M. Davies,et al.  Insulin Deficiency and Increased Plasma Concentration of Intact and 32/33 Split Proinsulin in Subjects with Impaired Glucose Tolerance , 1993, Diabetic medicine : a journal of the British Diabetic Association.

[8]  W. Sheu,et al.  Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. , 1993, The Journal of clinical endocrinology and metabolism.

[9]  K. Alberti,et al.  Proinsulin and insulin concentrations following intravenous glucose challenges in normal, obese, and non-insulin-dependent diabetic subjects. , 1993, Metabolism: clinical and experimental.

[10]  R. DeFronzo,et al.  The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. , 1992, Diabetes.

[11]  N. Day,et al.  Raised proinsulin concentration as early indicator of beta cell dysfunction. , 1991, BMJ.

[12]  A. Fontbonne,et al.  Risk Factors for NIDDM in White Population: Paris Prospective Study , 1991, Diabetes.

[13]  M. Laakso,et al.  Asymptomatic hyperglycemia and cardiovascular risk factors in the elderly. , 1991, Atherosclerosis.

[14]  P. Bennett,et al.  A two-step model for development of non-insulin-dependent diabetes. , 1991, The American journal of medicine.

[15]  A. Krolewski,et al.  Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. , 1990, Annals of internal medicine.

[16]  M. Laakso,et al.  Prevalence of Diabetes and Impaired Glucose Tolerance in Elderly Subjects and Their Association With Obesity and Family History of Diabete , 1990, Diabetes Care.

[17]  P. Bennett,et al.  Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus. , 1990, The Journal of clinical endocrinology and metabolism.

[18]  S. Haffner,et al.  Incidence of Type II Diabetes in Mexican Americans Predicted by Fasting Insulin and Glucose Levels, Obesity, and Body-Fat Distribution , 1990, Diabetes.

[19]  S. Kahn,et al.  Hyperproinsulinemia and Amyloid in NIDDM: Clues to Etiology of Islet β-Cell Dysfunction? , 1989, Diabetes.

[20]  L. Groop,et al.  Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. , 1989, The New England journal of medicine.

[21]  P. Bennett,et al.  SEQUENTIAL CHANGES IN SERUM INSULIN CONCENTRATION DURING DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES , 1989, The Lancet.

[22]  D. Owens,et al.  Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. , 1989, The Biochemical journal.

[23]  D. Owens,et al.  INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES , 1989, The Lancet.

[24]  P. Bennett,et al.  The natural history of impaired glucose tolerance in the Pima Indians. , 1988, The New England journal of medicine.

[25]  R. Sicree,et al.  Plasma Insulin Response Among Nauruans: Prediction of Deterioration in Glucose Tolerance Over 6 Yr , 1987, Diabetes.

[26]  H. Yki-Järvinen,et al.  The effect of exogenous hyperinsulinemia on proinsulin secretion in normal man, obese subjects, and patients with insulinoma. , 1986, The Journal of clinical endocrinology and metabolism.

[27]  S. O’Rahilly,et al.  BETA-CELL DYSFUNCTION, RATHER THAN INSULIN INSENSITIVITY, IS THE PRIMARY DEFECT IN FAMILIAL TYPE 2 DIABETES , 1986, The Lancet.

[28]  K. Polonsky,et al.  The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes. , 1984, The Journal of clinical endocrinology and metabolism.

[29]  S. Efendić,et al.  On the Pathogenesis of Maturity-Onset Diabetes , 1981, Diabetes Care.

[30]  L. Stimmler.  Immunoassay of insulin with insulin antibody precipitate. , 1963, Lancet.