Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
暂无分享,去创建一个
Steven E. Arnold | Suzanne Craft | David M. Holtzman | D. Holtzman | S. Arnold | L. Stoeckel | R. Ahima | Z. Arvanitakis | S. Gandy | D. Nathan | S. Craft | Hoau Yan Wang | Sam Gandy | Hoau-Yan Wang | Zoe Arvanitakis | Shannon L. Macauley-Rambach | Aaron M. Koenig | C. Buettner | Christoph Buettner | David M. Nathan | Luke E. Stoeckel | Rexford S. Ahima | A. Koenig
[1] Sterling C. Johnson,et al. Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[2] J. Detre,et al. Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study , 2017, Alzheimer disease and associated disorders.
[3] Bryan J. Neth,et al. Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial , 2017, Journal of Alzheimer's disease : JAD.
[4] S. Agarwal,et al. Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders. , 2017, Biochemical and biophysical research communications.
[5] Matthias Gralle. The neuronal insulin receptor in its environment , 2017, Journal of neurochemistry.
[6] S. Allan,et al. Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease , 2016, Journal of Alzheimer's disease : JAD.
[7] C. Brayne,et al. Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology? , 2016, Brain pathology.
[8] C. Power,et al. HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation , 2017, Journal of Neuroimmune Pharmacology.
[9] T. Montine,et al. Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes , 2016, Neurobiology of Aging.
[10] E. McNay,et al. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory , 2016, The Journal of Neuroscience.
[11] J. Williamson,et al. Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes. , 2016, Journal of diabetes and its complications.
[12] V. Routh,et al. Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation , 2016, Diabetes.
[13] H. Gu,et al. Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction , 2016, Brain Imaging and Behavior.
[14] C. Hölscher,et al. Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases , 2016, Reviews in the neurosciences.
[15] M. Sander,et al. Mechanisms of β‐cell functional adaptation to changes in workload , 2016, Diabetes, obesity & metabolism.
[16] F. Schmitt,et al. Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology , 2016, Alzheimer's & Dementia.
[17] Impaired fasting glucose is associated with increased regional cerebral amyloid , 2016, Neurobiology of Aging.
[18] M. Ehrlich,et al. Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels , 2016, Alzheimer's & Dementia.
[19] D. Holtzman,et al. Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence? , 2016, The Journal of experimental medicine.
[20] D. Tropea,et al. The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity , 2016, Neuroscience.
[21] J. Fadel,et al. Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits , 2016, Current Opinion in Behavioral Sciences.
[22] G. King,et al. Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture , 2016, Diabetes.
[23] P. D. Meyts. The Insulin Receptor and Its Signal Transduction Network , 2016 .
[24] N. Kimura. Diabetes Mellitus Induces Alzheimer’s Disease Pathology: Histopathological Evidence from Animal Models , 2016, International journal of molecular sciences.
[25] Á. Pascual-Leone,et al. "White Paper" meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. , 2016, F1000Research.
[26] D. Yoo,et al. Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus , 2016, The Journal of veterinary medical science.
[27] D. El-Lebedy,et al. Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease , 2016, Cardiovascular Diabetology.
[28] Sher Ali,et al. Genes, Genetics, and Environment in Type 2 Diabetes: Implication in Personalized Medicine. , 2016, DNA and cell biology.
[29] Derek K. Jones,et al. White Matter Microstructure and Cognitive Function in Young Women With Polycystic Ovary Syndrome , 2015, Journal of Clinical Endocrinology and Metabolism.
[30] D. Devanand,et al. Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial. , 2016, Journal of Alzheimer's disease : JAD.
[31] M. Woodward,et al. Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia , 2015, Diabetes Care.
[32] H. Rao,et al. Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI , 2015, Medicine.
[33] B. Stollery,et al. Glucose improves object-location binding in visual-spatial working memory , 2015, Psychopharmacology.
[34] V. Srikanth,et al. Type 2 diabetes mellitus and biomarkers of neurodegeneration , 2015, Neurology.
[35] L. Pantoni,et al. Is type 2 diabetes related to leukoaraiosis? an updated review , 2015, Acta neurologica Scandinavica.
[36] Sterling C. Johnson,et al. Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease. , 2015, JAMA neurology.
[37] D. Walker,et al. Insulin Modulates In Vitro Secretion of Cytokines and Cytotoxins by Human Glial Cells. , 2015, Current Alzheimer research.
[38] P. Heath,et al. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors , 2015, Molecular Brain.
[39] M. Boehnke,et al. Recent advances in understanding the genetic architecture of type 2 diabetes. , 2015, Human molecular genetics.
[40] C. DeCarli,et al. Glucose indices are associated with cognitive and structural brain measures in young adults , 2015, Neurology.
[41] H. Rao,et al. Disrupted resting-state attentional networks in T2DM patients , 2015, Scientific Reports.
[42] J. Schneider,et al. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease , 2015, Alzheimer's & Dementia.
[43] D. Butterfield,et al. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive impairment and late‐stage AD , 2015, Journal of neurochemistry.
[44] J. Walsh,et al. High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity , 2015, PloS one.
[45] W. Maetzler,et al. The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier? , 2015, PloS one.
[46] Sterling C. Johnson,et al. Insulin resistance predicts brain amyloid deposition in late middle-aged adults , 2015, Alzheimer's & Dementia.
[47] H. Rao,et al. Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study , 2015, BioMed research international.
[48] M. Diamond,et al. Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test , 2015, Journal of diabetes research.
[49] Jian Wang,et al. Memory Dysfunction in Type 2 Diabetes Mellitus Correlates with Reduced Hippocampal CA1 and Subiculum Volumes , 2015, Chinese medical journal.
[50] K. Ishii,et al. Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies , 2015, Journal of the Neurological Sciences.
[51] Dimitrios Kapogiannis,et al. Insulin Resistance Predicts Medial Temporal Hypermetabolism in Mild Cognitive Impairment Conversion to Alzheimer Disease , 2015, Diabetes.
[52] A. Goate,et al. Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis , 2015, Biological Psychiatry.
[53] Emily H. Trittschuh,et al. Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. , 2015, Journal of Alzheimer's disease : JAD.
[54] J. Freiherr,et al. Central insulin administration improves odor-cued reactivation of spatial memory in young men. , 2015, The Journal of clinical endocrinology and metabolism.
[55] Sterling C. Johnson,et al. Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOEɛ4 Carriers. , 2015, Journal of Alzheimer's disease : JAD.
[56] J. Schmeidler,et al. Neuropathology of type 2 diabetes: a short review on insulin-related mechanisms , 2014, European Neuropsychopharmacology.
[57] M. Brundel,et al. Brain imaging in type 2 diabetes , 2014, European Neuropsychopharmacology.
[58] P. Kahle,et al. Diet‐induced obesity accelerates the onset of terminal phenotypes in α‐synuclein transgenic mice , 2014, Journal of neurochemistry.
[59] Richard D. Smith,et al. Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. , 2014, Cell metabolism.
[60] Jing Fang,et al. Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes , 2014, Diabetes.
[61] C. Torborg,et al. Recommendations of the Alzheimer's Disease–Related Dementias Conference , 2014, Neurology.
[62] J. Trojanowski,et al. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies , 2014, Acta Neuropathologica.
[63] I. Lucki,et al. High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice , 2014, Neurobiology of Disease.
[64] N. Cámpora,et al. Cardiovascular risk factors and frontotemporal dementia: a case–control study , 2014, Translational Neurodegeneration.
[65] S. Arnold,et al. Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease , 2014, Diabetes.
[66] C. Jack,et al. Diabetes and Elevated Hemoglobin A1c Levels Are Associated with Brain Hypometabolism but Not Amyloid Accumulation , 2014, The Journal of Nuclear Medicine.
[67] René Westerhausen,et al. Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation , 2014, Human brain mapping.
[68] Gwenn S. Smith,et al. The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging , 2014, Psychiatry Research: Neuroimaging.
[69] Cheng Hu,et al. Genetics of Type 2 Diabetes: Insights into the Pathogenesis and Its Clinical Application , 2014, BioMed research international.
[70] E. Benarroch. Brain glucose transporters , 2014, Neurology.
[71] Luca Cucullo,et al. Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview. , 2014, Journal of pharmacovigilance.
[72] Eric D. Vidoni,et al. Impaired glycemia increases disease progression in mild cognitive impairment , 2014, Neurobiology of Aging.
[73] P. Novak,et al. Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes , 2014, Diabetes Care.
[74] H. Preissl,et al. Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans. , 2014, The Journal of clinical endocrinology and metabolism.
[75] L. Rui,et al. Energy metabolism in the liver. , 2014, Comprehensive Physiology.
[76] Joan C. Borod,et al. Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus , 2014, Journal of clinical and experimental neuropsychology.
[77] L. Ación,et al. Cognitive dysfunctions in middle-aged type 2 diabetic patients and neuroimaging correlations: a cross-sectional study. , 2014, Journal of Alzheimer's disease : JAD.
[78] J. Jurčovičová,et al. Glucose transport in brain - effect of inflammation. , 2014, Endocrine regulations.
[79] M. Synofzik,et al. Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans , 2014, Acta Diabetologica.
[80] C. Hölscher,et al. New animal models of Alzheimer’s disease that display insulin desensitization in the brain , 2013, Reviews in the neurosciences.
[81] J. Kielstein,et al. Glucose levels and risk of dementia. , 2013, The New England journal of medicine.
[82] T. Spires-Jones,et al. Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice , 2013, Psychoneuroendocrinology.
[83] F. Bai,et al. Altered baseline brain activity in type 2 diabetes: A resting-state fMRI study , 2013, Psychoneuroendocrinology.
[84] L. Ferrucci,et al. Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging , 2013, Neurobiology of Aging.
[85] L. Ferrucci,et al. Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging. , 2013, JAMA neurology.
[86] S. Haneuse,et al. Glucose levels and risk of dementia. , 2013, The New England journal of medicine.
[87] Mark T. W. Ebbert,et al. Genetics of Alzheimer's Disease , 2013, BioMed research international.
[88] M. Sabbagh,et al. Increased Alzheimer's disease neuropathology is associated with type 2 diabetes and ApoE ε.4 carrier status. , 2013, Current Alzheimer research.
[89] R. Albin,et al. Diabetes is associated with postural instability and gait difficulty in Parkinson disease. , 2013, Parkinsonism & related disorders.
[90] A. Bhansali,et al. Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies , 2013, Journal of diabetes investigation.
[91] Sterling C. Johnson,et al. Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle–Aged Adults , 2013, Diabetes Care.
[92] H. Arai,et al. Brain accumulation of amyloid β protein visualized by positron emission tomography and BF‐227 in Alzheimer's disease patients with or without diabetes mellitus , 2013, Geriatrics & gerontology international.
[93] F. D. De Felice. Alzheimer's disease and insulin resistance: translating basic science into clinical applications. , 2013, The Journal of clinical investigation.
[94] G. Eslick,et al. Type 2 diabetes as a risk factor for Alzheimer's disease: the confounders, interactions, and neuropathology associated with this relationship. , 2013, Epidemiologic reviews.
[95] James D. Johnson,et al. Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. , 2012, Cell metabolism.
[96] K. Kawabe,et al. Clinical Features of Parkinson Disease when Onset of Diabetes Came First: A Case-Control Study , 2012, Neurology.
[97] W. Banks,et al. Insulin in the brain: there and back again. , 2012, Pharmacology & therapeutics.
[98] A. Convit,et al. Obesity and Metabolic Syndrome and Functional and Structural Brain Impairments in Adolescence , 2012, Pediatrics.
[99] J. Cauley,et al. Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia. , 2012, Archives of neurology.
[100] Nick C Fox,et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. , 2012, The New England journal of medicine.
[101] M. Shenton,et al. Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes , 2012, Diabetes.
[102] Chih-Cheng Hsu,et al. Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort. , 2012, Parkinsonism & related disorders.
[103] Y. Reijmer,et al. Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes. , 2012, Journal of diabetes and its complications.
[104] R. Chaudhary,et al. Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease , 2012, Cardiovascular Diabetology.
[105] Domenico Consoli,et al. Dementia is associated with Insulin Resistance in patients with Parkinson's Disease , 2012, Journal of the Neurological Sciences.
[106] Chung-Yi Li,et al. Risk of Parkinson Disease Onset in Patients With Diabetes , 2012, Diabetes Care.
[107] D. Munoz,et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. , 2012, The Journal of clinical investigation.
[108] J. Schneider,et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. , 2012, The Journal of clinical investigation.
[109] Samantha J. Brooks,et al. Impaired Insulin Sensitivity as Indexed by the HOMA Score Is Associated With Deficits in Verbal Fluency and Temporal Lobe Gray Matter Volume in the Elderly , 2012, Diabetes Care.
[110] T. Montine,et al. Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment A Pilot Clinical Trial , 2011 .
[111] A. Convit,et al. Type 2 diabetes affects hippocampus volume differentially in men and women , 2012, Diabetes/metabolism research and reviews.
[112] V. Haroutunian,et al. Changes in glycemic control are associated with changes in cognition in non-diabetic elderly. , 2012, Journal of Alzheimer's disease : JAD.
[113] S. M. de la Monte. Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease. , 2012, Frontiers in bioscience.
[114] A. Reiss,et al. Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease , 2011, Neurobiology of Aging.
[115] S. Kanba,et al. Glucose tolerance status and risk of dementia in the community , 2011, Neurology.
[116] K. Hsu,et al. Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways , 2011, Neuropharmacology.
[117] A. Saunders,et al. Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies. , 2011, Current Alzheimer research.
[118] Sudha Seshadri,et al. Association of Metabolic Dysregulation With Volumetric Brain Magnetic Resonance Imaging and Cognitive Markers of Subclinical Brain Aging in Middle-Aged Adults , 2011, Diabetes Care.
[119] M. Heni,et al. Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes , 2011, PloS one.
[120] P. Lee,et al. Mid-life and late-life vascular risk factors and dementia in Korean men and women. , 2011, Archives of gerontology and geriatrics.
[121] Xuemei Huang,et al. Diabetes and Risk of Parkinson’s Disease , 2011, Diabetes Care.
[122] R. Zechner,et al. Brain insulin controls adipose tissue lipolysis and lipogenesis. , 2011, Cell metabolism.
[123] S. Minoshima,et al. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. , 2011, Archives of neurology.
[124] J. Mielke,et al. Insulin, synaptic function, and opportunities for neuroprotection. , 2011, Progress in molecular biology and translational science.
[125] Hubert Preissl,et al. Insulin Modulation of Magnetoencephalographic Resting State Dynamics in Lean and Obese Subjects , 2010, Front. Syst. Neurosci..
[126] A. Hofman,et al. Insulin metabolism and the risk of Alzheimer disease , 2010, Neurology.
[127] Jan Born,et al. Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory. , 2010, The Journal of clinical endocrinology and metabolism.
[128] Rudolph E Tanzi,et al. Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex , 2010, The Journal of Neuroscience.
[129] B. Winblad,et al. Diabetes, Alzheimer disease, and vascular dementia , 2010, Neurology.
[130] J. Antel,et al. Response of Human Oligodendrocyte Progenitors to Growth Factors and Axon Signals , 2010, Journal of neuropathology and experimental neurology.
[131] K. Blennow,et al. Cerebrospinal fluid insulin during non-neurological surgery , 2010, Journal of Neural Transmission.
[132] B. A. Ardekani,et al. Preliminary evidence for brain complications in obese adolescents with type 2 diabetes mellitus , 2010, Diabetologia.
[133] Victoria E. Cotero,et al. Mini-review: Impact of recurrent hypoglycemia on cognitive and brain function , 2010, Physiology & Behavior.
[134] Jesús Avila,et al. Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors , 2010, Expert review of neurotherapeutics.
[135] I. Torres-Aleman,et al. Toward a comprehensive neurobiology of IGF‐I , 2010, Developmental neurobiology.
[136] Hubert Preissl,et al. Insulin modulates food-related activity in the central nervous system. , 2010, The Journal of clinical endocrinology and metabolism.
[137] Rosemary O’Connor,et al. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling , 2010, Neurobiology of Aging.
[138] J. Born,et al. Euglycemic Infusion of Insulin Detemir Compared With Human Insulin Appears to Increase Direct Current Brain Potential Response and Reduces Food Intake While Inducing Similar Systemic Effects , 2010, Diabetes.
[139] D. Clegg,et al. Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats. , 2010, American journal of physiology. Regulatory, integrative and comparative physiology.
[140] Suzanne Timmons,et al. Akt signal transduction dysfunction in Parkinson's disease , 2009, Neuroscience Letters.
[141] C. Grillo,et al. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent , 2009, Brain Research.
[142] Charles D. Smith,et al. Human cerebral neuropathology of Type 2 diabetes mellitus. , 2009, Biochimica et biophysica acta.
[143] L. Kappelle,et al. Cognition in the Early Stage of Type 2 Diabetes , 2009, Diabetes Care.
[144] J. Henquin. Regulation of insulin secretion: a matter of phase control and amplitude modulation , 2009, Diabetologia.
[145] Stephan Züchner,et al. Genomic convergence to identify candidate genes for Alzheimer Disease on chromosome 10 , 2009, Human mutation.
[146] Paul K Crane,et al. Different patterns of cerebral injury in dementia with or without diabetes. , 2009, Archives of neurology.
[147] H. Soininen,et al. β‐Amyloid deposition in brains of subjects with diabetes , 2009, Neuropathology and applied neurobiology.
[148] S. M. de la Monte,et al. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. , 2009, Journal of Alzheimer's disease : JAD.
[149] M. Arami,et al. Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment. , 2008, Diabetes research and clinical practice.
[150] Sherita Hill Golden,et al. Depression and Type 2 Diabetes Over the Lifespan , 2008, Diabetes Care.
[151] B. Pakkenberg,et al. Neocortical glial cell numbers in human brains , 2008, Neurobiology of Aging.
[152] J. Buring,et al. Prospective Cohort Study of Type 2 Diabetes and the Risk of Parkinson's Disease , 2008, Diabetes Care.
[153] V. Haroutunian,et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology , 2008, Neurology.
[154] Nancy L. Pedersen,et al. O1-05-08: Mid- and late-life diabetes in relation to the risk of dementia: A population-based twin study , 2008, Alzheimer's & Dementia.
[155] Hollis T. Cline,et al. Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo , 2008, Neuron.
[156] D. Alkon,et al. Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair. , 2008, European journal of pharmacology.
[157] J. Born,et al. Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. , 2008, The Journal of clinical endocrinology and metabolism.
[158] Simon Lovestone,et al. The GSK3 hypothesis of Alzheimer's disease , 2008, Journal of neurochemistry.
[159] J. Born,et al. Obese men respond to cognitive but not to catabolic brain insulin signaling , 2008, International Journal of Obesity.
[160] G. Schellenberg,et al. Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. , 2008, Journal of Alzheimer's disease : JAD.
[161] H. Preissl,et al. Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans , 2008, Diabetologia.
[162] D. Leroith,et al. Insulin and insulin-like growth factor receptors in the nervous system , 2008, Molecular Neurobiology.
[163] B. Yandell,et al. SORCS1: A Novel Human Type 2 Diabetes Susceptibility Gene Suggested by the Mouse , 2007, Diabetes.
[164] G. Lienhard,et al. Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. , 2007, Cell metabolism.
[165] Richard Mayeux,et al. Relation of diabetes to mild cognitive impairment. , 2007, Archives of neurology.
[166] G. Collingridge,et al. LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β , 2007, Neuron.
[167] A. Convit,et al. Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes , 2007, Diabetologia.
[168] D. Bennett,et al. Diabetes is related to cerebral infarction but not to AD pathology in older persons , 2006, Neurology.
[169] Y. T. Wang,et al. Endogenous insulin signaling protects cultured neurons from oxygen–glucose deprivation-induced cell death , 2006, Neuroscience.
[170] Geert Jan Biessels,et al. Brain Imaging in Patients With Diabetes , 2006, Diabetes Care.
[171] Paul K. Marsden,et al. Attenuation of Insulin-Evoked Responses in Brain Networks Controlling Appetite and Reward in Insulin Resistance , 2006, Diabetes.
[172] F. Kim,et al. Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis , 2006, Brain Research.
[173] N. Birbaumer,et al. The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study , 2006, Proceedings of the National Academy of Sciences.
[174] G. Ramakers,et al. Insulin signaling in the central nervous system: Learning to survive , 2006, Progress in Neurobiology.
[175] D. Bennett,et al. Diabetes mellitus, dementia, and cognitive function in older persons. , 2006, The Journal of Nutrition, Health & Aging.
[176] P. Zandi,et al. Vascular Risk Factors for Incident Alzheimer Disease and Vascular Dementia: The Cache County Study , 2006, Alzheimer disease and associated disorders.
[177] Jeroen van der Grond,et al. Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. , 2006, Diabetes.
[178] E. Uemura,et al. Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3 , 2006, Experimental Neurology.
[179] G. Schellenberg,et al. Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype , 2006, Neurobiology of Aging.
[180] P. Scheltens,et al. Risk of dementia in diabetes mellitus: a systematic review , 2006, The Lancet Neurology.
[181] B. Winblad,et al. Levels of mTOR and its downstream targets 4E‐BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain , 2005, The FEBS journal.
[182] A. Artola,et al. Insulin modulates hippocampal activity‐dependent synaptic plasticity in a N‐methyl‐d‐aspartate receptor and phosphatidyl‐inositol‐3‐kinase‐dependent manner , 2005, Journal of neurochemistry.
[183] K. Nanjo,et al. Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions , 2005, Brain Research.
[184] Yu Wang,et al. A biochemical and functional characterization of diet‐induced brain insulin resistance , 2005, Journal of neurochemistry.
[185] Gary J. Schwartz,et al. Hypothalamic KATP channels control hepatic glucose production , 2005, Nature.
[186] R. Ravid,et al. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology , 2005, Journal of neurochemistry.
[187] J. Wands,et al. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. , 2005, Journal of Alzheimer's disease : JAD.
[188] J. Wands,et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? , 2005, Journal of Alzheimer's disease : JAD.
[189] R. Nitsch,et al. Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type , 2005, Journal of Neural Transmission.
[190] Y. Han,et al. Insulin inhibits AMPA-induced neuronal damage via stimulation of protein kinase B (Akt) , 2005, Journal of Neural Transmission.
[191] A. Newman,et al. The metabolic syndrome, inflammation, and risk of cognitive decline. , 2004, JAMA.
[192] Jan Born,et al. Intranasal insulin improves memory in humans , 2004, Psychoneuroendocrinology.
[193] J. Born,et al. Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain. , 2004, Diabetes.
[194] E. Barrett-Connor,et al. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women , 2004, Neurology.
[195] Bengt Winblad,et al. Akt activity in Alzheimer's disease and other neurodegenerative disorders , 2004, Neuroreport.
[196] B. McEwen,et al. Glucose transporter expression in the central nervous system: relationship to synaptic function. , 2004, European journal of pharmacology.
[197] William A Banks,et al. The source of cerebral insulin. , 2004, European journal of pharmacology.
[198] F. Grodstein,et al. Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years , 2004, BMJ : British Medical Journal.
[199] K. Hirayama,et al. Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease , 1994, Acta Neuropathologica.
[200] M. Permutt,et al. Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues , 1985, Diabetologia.
[201] B. Wróblewska,et al. The binding of insulin to cerebral capillaries and astrocytes of the rat , 1982, Neurochemical Research.
[202] P. J. Koudstaal,et al. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI , 2003, Diabetologia.
[203] Debashis Ghosh,et al. Impact of diabetes on cognitive function among older Latinos: a population-based cohort study. , 2003, Journal of clinical epidemiology.
[204] J. Meigs,et al. The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging. , 2003, Diabetes.
[205] D. Ghosh,et al. Impact of antidiabetic medications on physical and cognitive functioning of older Mexican Americans with diabetes mellitus: a population-based cohort study. , 2003, Annals of epidemiology.
[206] S. Woods,et al. Insulin and the blood-brain barrier. , 2003, Current pharmaceutical design.
[207] D. Ghosh,et al. Diabetes as a predictor of change in functional status among older Mexican Americans: a population-based cohort study. , 2003, Diabetes care.
[208] Karen J. Ferguson,et al. Increased blood–brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging , 2003, Journal of neurology, neurosurgery, and psychiatry.
[209] H. Braak,et al. Role of protein kinase B in Alzheimer's neurofibrillary pathology , 2003, Acta Neuropathologica.
[210] P. E. Gold,et al. Food for thought: fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulation. , 2002, Behavioral and cognitive neuroscience reviews.
[211] L. Rossetti,et al. Hypothalamic insulin signaling is required for inhibition of glucose production , 2002, Nature Medicine.
[212] J. Bockmann,et al. ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53 , 2002, Journal of neurochemistry.
[213] B. Goldstein. Insulin resistance as the core defect in type 2 diabetes mellitus. , 2002, The American journal of cardiology.
[214] G. Mcclearn,et al. Diabetes Mellitus Is a Risk Factor for Vascular Dementia, but Not for Alzheimer's Disease: A Population-Based Study of the Oldest Old , 2002, International Psychogeriatrics.
[215] K. Rockwood,et al. Diabetes mellitus and the Risk of Dementia, Alzheimer’s Disease and Vascular Cognitive Impairment in the Canadian Study of Health and Aging , 2002, Dementia and Geriatric Cognitive Disorders.
[216] P. Ye,et al. Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination. , 2002, Brain research. Developmental brain research.
[217] Zhaohui Feng,et al. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats , 2002, Nature Neuroscience.
[218] E. Air,et al. Acute third ventricular administration of insulin decreases food intake in two paradigms , 2002, Pharmacology Biochemistry and Behavior.
[219] R. Mayeux,et al. The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function , 2002, Neurology.
[220] L. Launer,et al. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. , 2002, Diabetes.
[221] H. Soininen,et al. Midlife vascular risk factors and late-life mild cognitive impairment , 2001, Neurology.
[222] J. Manson,et al. Type 2 diabetes and cognitive function in community-dwelling elderly women. , 2001, Diabetes care.
[223] R. Duelli,et al. Brain glucose transporters: relationship to local energy demand. , 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.
[224] B L Miller,et al. Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. , 2001, Archives of neurology.
[225] P Ducimetière,et al. Changes in cognitive abilities over a 4-year period are unfavorably affected in elderly diabetic subjects: results of the Epidemiology of Vascular Aging Study. , 2001, Diabetes care.
[226] R A Swanson,et al. Astrocytic Glycogen Influences Axon Function and Survival during Glucose Deprivation in Central White Matter , 2000, The Journal of Neuroscience.
[227] R. Martins,et al. Insulin Effects on Glucose Metabolism, Memory, and Plasma Amyloid Precursor Protein in Alzheimer's Disease Differ According to Apolipoprotein‐E Genotype , 2000, Annals of the New York Academy of Sciences.
[228] P. E. Gold,et al. Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[229] D. Alkon,et al. Brain Insulin Receptors and Spatial Memory , 1999, The Journal of Biological Chemistry.
[230] A Hofman,et al. Diabetes mellitus and the risk of dementia , 1999, Neurology.
[231] R. Schliebs,et al. Insulin‐sensitive GLUT4 glucose transporters are colocalized with GLUT3‐expressing cells and demonstrate a chemically distinct neuron‐specific localization in rat brain , 1999, Journal of neuroscience research.
[232] M. Abbott,et al. The Insulin Receptor Tyrosine Kinase Substrate p58/53 and the Insulin Receptor Are Components of CNS Synapses , 1999, The Journal of Neuroscience.
[233] J. Born,et al. Central nervous system effects of intranasally administered insulin during euglycemia in men. , 1999, Diabetes.
[234] R. Stewart,et al. Type 2 diabetes mellitus, cognitive impairment and dementia , 1999, Diabetic medicine : a journal of the British Diabetic Association.
[235] J. Unger,et al. Insulin receptors and signal transduction proteins in the hypothalamo-hypophyseal system: a review on morphological findings and functional implications. , 1998, Histology and histopathology.
[236] P. Magistretti,et al. Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle , 1998, Developmental Neuroscience.
[237] K. Jellinger,et al. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease , 1998, Journal of Neural Transmission.
[238] S. Hoyer,et al. Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis , 1998, Journal of Neural Transmission.
[239] W. Banks,et al. Transport of Insulin Across the Blood-Brain Barrier: Saturability at Euglycemic Doses of Insulin , 1997, Peptides.
[240] J. Heitner,et al. Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects , 1997, Neurology.
[241] I. Deary,et al. Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies , 1997, Diabetes Care.
[242] M. Laakso,et al. Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR) , 1996, Diabetes.
[243] Hiroshi Kimura,et al. Insulin receptor mRNA in the substantia nigra in Parkinson's disease , 1996, Neuroscience Letters.
[244] D. S. Zahm,et al. Insulin gene expression and insulin synthesis in mammalian neuronal cells. , 1994, The Journal of biological chemistry.
[245] S. Devaskar,et al. Insulin II gene expression in rat central nervous system , 1993, Regulatory Peptides.
[246] C Cobelli,et al. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. , 1993, The Journal of clinical investigation.
[247] O. Madsen,et al. Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[248] R Sandyk,et al. The relationship between diabetes mellitus and Parkinson's disease. , 1993, The International journal of neuroscience.
[249] S. Woods,et al. Insulin in the brain: a hormonal regulator of energy balance. , 1992, Endocrine reviews.
[250] R. Schechter,et al. Developmental regulation of insulin in the mammalian central nervous system , 1992, Brain Research.
[251] L. Fisher,et al. Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport. , 1991, The Journal of clinical investigation.
[252] J. Fleg,et al. Age as Independent Determinant of Glucose Tolerance , 1991, Diabetes.
[253] D. Porte,et al. Localization of insulin receptor mRNA in rat brain by in situ hybridization. , 1990, Endocrinology.
[254] K. O’Malley,et al. Analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues. , 1990, Brain research. Molecular brain research.
[255] G. Reaven,et al. Relationship Between Hyperglycemia and Cognitive Function in Older NIDDM Patients , 1990, Diabetes Care.
[256] G. Werther,et al. Localization and Characterization of Insulin‐Like Growth Factor‐I Receptors in Rat Brain and Pituitary Gland Using in vitro Autoradiography and Computerized Densitometry * A Distinct Distribution from Insulin Receptors , 1989, Journal of neuroendocrinology.
[257] P. R. Gilmore,et al. Glucose transport in primary cultured neurons , 1989, Journal of neuroscience research.
[258] G. Werther,et al. Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. , 1987, Endocrinology.
[259] D. Porte,et al. Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man. , 1987, The Journal of clinical endocrinology and metabolism.
[260] M. Raizada,et al. Insulin Is Released from Rat Brain Neuronal Cells in Culture , 1986, Journal of neurochemistry.
[261] W. Young. Periventricular hypothalamic cells in the rat brain contain insulin mRNA , 1986, Neuropeptides.
[262] W. Pardridge,et al. Human Blood—Brain Barrier Insulin Receptor , 1985, Journal of neurochemistry.
[263] D. Singer,et al. Decreased cognitive function in aging non-insulin-dependent diabetic patients. , 1984, The American journal of medicine.
[264] M. Raizada,et al. Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain. , 1984, The Journal of biological chemistry.
[265] B. Winblad,et al. Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type. , 2009, Acta medica Scandinavica.
[266] S. Woods,et al. The role of insulin as a satiety factor in the central nervous system. , 1983, Advances in metabolic disorders.
[267] B. Ajaya,et al. Effects of insulin administered into cerebrospinal fluid spaces on blood glucose in unanaesthetized and anaesthetized dogs. , 1982, The Indian journal of medical research.
[268] H. Bernstein,et al. C-peptide immunoreactive neurons in human brain. , 1982, Acta histochemica.
[269] Ralph A. DeFronzo. Glucose Intolerance and Aging , 1981, Diabetes Care.
[270] S. Woods,et al. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons , 1979, Nature.
[271] J. Strubbe,et al. Increased feeding in response to bilateral injection of insulin antibodies in the VMH , 1977, Physiology & Behavior.
[272] W. Millard,et al. Short-term influence of intra-ventromedial hypothalamic administration of insulin on feeding in normal and diabetic rats. , 1974, Pharmacology, biochemistry, and behavior.
[273] S. Aronson. INTRACRANIAL VASCULAR LESIONS IN PATIENTS WITH DIABETES MELLITUS , 1973, Journal of neuropathology and experimental neurology.
[274] A. Debons,et al. A direct action of insulin on the hypothalamic satiety center. , 1970, The American journal of physiology.
[275] R. Snider. The Human Brain in Figures and Tables , 1969, Neurology.
[276] M. Rinkel,et al. INSULIN TREATMENT IN PSYCHIATRY , 1959, The Ulster Medical Journal.
[277] W. R. Miles,et al. PSYCHOLOGIC TESTS APPLIED TO DIABETIC PATIENTS , 1922 .