Survival for immunity: the price of immune system activation for bumblebee workers.

Parasites do not always harm their hosts because the immune system keeps an infection at bay. Ironically, the cost of using immune defenses could itself reduce host fitness. This indirect cost of parasitism is often not visible because of compensatory resource intake. Here, workers of the bumblebee, Bombus terrestris, were challenged with lipopolysaccharides and micro-latex beads to induce their immune system under starvation (i.e., not allowing compensatory intake). Compared with controls, survival of induced workers was significantly reduced (by 50 to 70%).

[1]  D. Hultmark,et al.  Immune reactions in Drosophila and other insects: a model for innate immunity. , 1993, Trends in genetics : TIG.

[2]  K. Kadono-Okuda,et al.  Clearance of lipopolysaccharide in hemolymph of the silkworm Bombyx mori: Its role in the termination of cecropin mRNA induction , 1994 .

[3]  L. Dill,et al.  COSTS OF ENERGY SHORTFALL FOR BUMBLE BEE COLONIES: PREDATION, SOCIAL PARASITISM, AND BROOD DEVELOPMENT , 1991, The Canadian Entomologist.

[4]  N. Ratcliffe,et al.  Invertebrate Immunity: Basic Concepts and Recent Advances , 1985 .

[5]  G. Yan,et al.  COSTS AND BENEFITS OF MOSQUITO REFRACTORINESS TO MALARIA PARASITES: IMPLICATIONS FOR GENETIC VARIABILITY OF MOSQUITOES AND GENETIC CONTROL OF MALARIA , 1997, Evolution; international journal of organic evolution.

[6]  P. Schmid-Hempel,et al.  Foraging activity and immunocompetence in workers of the bumble bee, Bombus terrestris L , 1995, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[7]  P. Schmid-Hempel,et al.  Incidence and effects of four parasites in natural populations of bumble bees in Switzerland , 1991 .

[8]  W. Zhang,et al.  Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures. , 1994, The Journal of biological chemistry.

[9]  S. Zohari,et al.  Reproductive effort reduces specific immune response and parasite resistance , 1998, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[10]  T. Jomori,et al.  Purification and characterization of lipopolysaccharide-binding protein from hemolymph of American cockroach Periplaneta americana. , 1990, European journal of biochemistry.

[11]  K. Söderhäll.  Prophenoloxidase activating system and melanization - a recognition mechanism of arthropods? A review. , 1982, Developmental and comparative immunology.

[12]  H. Yokosawa,et al.  A novel lipopolysaccharide-binding hemagglutinin isolated from hemocytes of the solitary ascidian, Halocynthia roretzi: it can agglutinate bacteria. , 1991, Developmental and comparative immunology.

[13]  B. Sheldon,et al.  Ecological immunology: costly parasite defences and trade-offs in evolutionary ecology. , 1996, Trends in ecology & evolution.

[14]  K. Kadono-Okuda,et al.  Lipopolysaccharide-lipophorin complex formation in insect hemolymph: a common pathway of lipopolysaccharide detoxification both in insects and in mammals. , 1994, Insect biochemistry and molecular biology.

[15]  H. Godfray,et al.  Trade-off between parasitoid resistance and larval competitive ability in Drosophila melanogaster , 1997, Nature.

[16]  R. Lenski.  EXPERIMENTAL STUDIES OF PLEIOTROPY AND EPISTASIS IN ESCHERICHIA COLI. I. VARIATION IN COMPETITIVE FITNESS AMONG MUTANTS RESISTANT TO VIRUS T4 , 1988, Evolution; international journal of organic evolution.

[17]  M. Moniatte,et al.  Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea). , 1997, Insect biochemistry and molecular biology.

[18]  M. Begon,et al.  Trade-offs with resistance to a granulosis virus in the Indian meal moth, examined by a laboratory evolution experiment , 1993 .