Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay.

[1]  R. G. Klein,et al.  Systemic genotoxic effects of tobacco-related nitrosamines following oral and inhalational administration to Sprague-Dawley rats , 1992, The clinical investigator.

[2]  N. Mathur,et al.  The effect of smoking and eating habits on DNA damage in Indian population as measured in the Comet assay. , 2001, Mutation research.

[3]  G. Yang,et al.  Tea and tea polyphenols in cancer prevention. , 2000, Advances in experimental medicine and biology.

[4]  C. Ioannides,et al.  Effect of antioxidant flavonoids and a food mutagen on lymphocytes of a thalassemia patient without chelation therapy in the Comet assay. , 2001, Teratogenesis, carcinogenesis, and mutagenesis.

[5]  M. Clifford,et al.  Hippuric acid as a major excretion product associated with black tea consumption , 2000, Xenobiotica; the fate of foreign compounds in biological systems.

[6]  R. Schulte‐Hermann,et al.  Search for Compounds That Inhibit the Genotoxic and Carcinogenic Effects of Heterocyclic Aromatic Amines , 2000, Critical reviews in toxicology.

[7]  J. Lin,et al.  Cancer chemoprevention by tea polyphenols. , 2000, Proceedings of the National Science Council, Republic of China. Part B, Life sciences.

[8]  C. Ioannides,et al.  Differential modulation of the genotoxicity of food carcinogens by naturally occurring monomeric and dimeric polyphenolics , 2000, Environmental and molecular mutagenesis.

[9]  R. Tice,et al.  Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing , 2000, Environmental and molecular mutagenesis.

[10]  H. Mukhtar,et al.  Green tea polyphenols and cancer: biologic mechanisms and practical implications. , 2009, Nutrition reviews.

[11]  R. Agarwal,et al.  Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. , 1999, Carcinogenesis.

[12]  C. Ioannides,et al.  Consumption of tea modulates the urinary excretion of mutagens in rats treated with IQ. Role of caffeine. , 1999, Mutation research.

[13]  C. Sempoux,et al.  Cytochrome P450 3A proteins are expressed in B lymphocytes but not in T lymphocytes. , 1999, Pharmacogenetics.

[14]  C. Ioannides,et al.  Modulation of hepatic cytochrome P450 activity and carcinogen bioactivation by black and decaffeinated black tea. , 1999, Environmental toxicology and pharmacology.

[15]  R. Mohan,et al.  A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model. , 1999, Cancer research.

[16]  C. Sempoux,et al.  CYP 3A proteins are expressed in human neutrophils and lymphocytes but are not induced by rifampicin. , 1999, Life sciences.

[17]  Y. Hara,et al.  Antimutagenic and anticarcinogenic activity of tea polyphenols. , 1999, Mutation research.

[18]  C. Ioannides,et al.  Contribution of theafulvins to the antimutagenicity of black tea: their mechanism of action. , 1998, Mutagenesis.

[19]  J. Rivas-Gonzalo,et al.  Analysis of flavanols in beverages by high-performance liquid chromatography with chemical reaction detection , 1998 .

[20]  C. Ioannides,et al.  Contribution of caffeine and flavanols in the induction of hepatic Phase II activities by green tea. , 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[21]  M. Dobrzyńska,et al.  Flavonoids modulate comet assay responses to food mutagens in human lymphocytes and sperm. , 1998, Mutation research.

[22]  H. Ashida,et al.  Antimutagenicity of flavones and flavonols to heterocyclic amines by specific and strong inhibition of the cytochrome P450 1A family. , 1998, Bioscience, biotechnology, and biochemistry.

[23]  C. Ioannides,et al.  Fractionation of green tea extracts: correlation of antimutagenic effect with flavanol content , 1997 .

[24]  C. S. Yang,et al.  Bioavailability of flavonoids from tea. , 1997, Critical reviews in food science and nutrition.

[25]  G. Yang,et al.  Black tea constituents, theaflavins, inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. , 1997, Carcinogenesis.

[26]  S. Anttila,et al.  Detection of mRNA encoding xenobiotic‐metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes , 1997, Molecular carcinogenesis.

[27]  G. Yang,et al.  Polyphenols as inhibitors of carcinogenesis. , 1997, Environmental health perspectives.

[28]  M. Boukharta,et al.  Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin. , 1997, International journal of oncology.

[29]  Norman R. Farnsworth,et al.  Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes , 1997, Science.

[30]  M. Dobrzyńska,et al.  Modulating effects of flavonoids on food mutagens in human blood and sperm samples in the comet assay. , 1997, Teratogenesis, carcinogenesis, and mutagenesis.

[31]  A. Davis,et al.  1H and 13C NMR Assignments of Some Green Tea Polyphenols , 1996 .

[32]  C. Ioannides,et al.  A comparison of the antimutagenic potential of green, black and decaffeinated teas: contribution of flavanols to the antimutagenic effect. , 1996, Mutagenesis.

[33]  P. Thomas,et al.  Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[34]  Z. Apostolides,et al.  Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) mutagenicity by black and green tea extracts and polyphenols. , 1996, Mutation research.

[35]  A. Davis,et al.  1H and 13C NMR assignment of theaflavin, theaflavin monogallate and theaflavin digallate , 1995 .

[36]  M. Clifford,et al.  Use of Porter's reagents for the characterisation of thearubigins and other non-proanthocyanidins , 1995 .

[37]  C. Ioannides,et al.  Stimulation of rat hepatic UDP-glucuronosyl transferase activity following treatment with green tea. , 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[38]  C. Ioannides,et al.  Selective induction of rat hepatic CYP1 and CYP4 proteins and of peroxisomal proliferation by green tea. , 1994, Carcinogenesis.

[39]  C. Ioannides,et al.  Marked antimutagenic potential of aqueous green tea extracts: mechanism of action. , 1994, Mutagenesis.

[40]  Y. Lou,et al.  Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice. , 1994, Cancer research.

[41]  E. Fiala,et al.  Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat. , 1994, Xenobiotica; the fate of foreign compounds in biological systems.

[42]  E. Feskens,et al.  Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study , 1993, The Lancet.

[43]  R. Klein,et al.  Assessment of genotoxic effects by lindane. , 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[44]  G. Block,et al.  Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. , 1992, Nutrition and cancer.

[45]  G. Wong,et al.  Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. , 1991, Carcinogenesis.

[46]  C. Omiecinski,et al.  Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction. , 1990, Cancer research.

[47]  R. Tice,et al.  A simple technique for quantitation of low levels of DNA damage in individual cells. , 1988, Experimental cell research.