Age-related trends of gastritis and intestinal metaplasia in gastric carcinoma patients and in controls representing the population at large.

Age-related trends of gastritis and intestinal metaplasia (IM) were studied in 476 endoscopically examined and bioptically proved cases of gastric carcinoma (GC), 263 of which were of intestinal (IGC) and 213 of diffuse (DGC) types. Endoscopic biopsy specimens from the area around the tumour were available in all cases, and from the antrum and/or body distant from the tumour area in 238 cases. A representative sample of an endoscopically and bioptically examined Finnish population consisting of 431 subjects was used as control material. In patients with IGC the prevalence of atrophic gastritis in the gastric area affected by the tumour was higher and that of superficial gastritis lower than expected, and the age-group scores of gastritis and IM were situated above the age-dependent line of gastritis scores of controls in all age groups studied. This was seen to indicate a more rapid progression of gastritis in IGC patients than in the population at large. In the opposite area of the stomach, i.e. in the tumour-free area, the progression of gastritis and IM was virtually similar to that in controls. No such differences were seen with regard to DGC. It is concluded that IGC is dynamically closely linked to gastritis and IM, while in DGC no such relationship is demonstrable.

[1]  M. Siurala,et al.  Long-term observation of subjects with normal mucosa and with superficial gastritis: results of 23--27 years' follow-up examinations. , 1978, Scandinavian journal of gastroenterology.

[2]  S. Tarpila,et al.  Ultrastructure of various metaplasias of the stomach. , 2009, Acta pathologica et microbiologica Scandinavica.

[3]  T. Takemoto,et al.  An Endoscopic Recognition of the Atrophic Border and its Significance in Chronic Gastritis , 1969 .

[4]  M. Siurala,et al.  Morphological, functional and immunological state of the gastric mucosa in gastric carcinoma families. Comparison with a computer-matched family sample. , 1979, Scandinavian journal of gastroenterology.

[5]  K. Varis.  A family study of chronic gastritis. Histological, immunological and functional aspects. , 1971, Scandinavian Journal of Gastroenterology, Supplement.

[6]  H. Nielsen,et al.  »Small Intestinal Type« and »Colonic Type« Intestinal Metaplasia of The Human Stomach, and Their Relationship to the Histogenetic Types of Gastric Adenocarcinoma , 1978, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.

[7]  P. Schlag,et al.  Gastritis, intestinal metaplasia and dysplasia versus benign ulcer in stomach and duodenum and gastric carcinoma -- a histotopographical study. , 1979, Pathology, research and practice.

[8]  M. Lipkin,et al.  CELL PROLIFERATION KINETICS IN THE GASTROINTESTINAL TRACT OF MAN. II. CELL RENEWAL IN STOMACH, ILEUM, COLON, AND RECTUM. , 1963, Gastroenterology.

[9]  K. Kawai,et al.  Epidemiology and pathogenesis of gastric cancer. , 1980, Frontiers of gastrointestinal research.

[10]  M. Siurala,et al.  The behaviour of gastritis and related conditions in different population samples. , 1981, Annals of clinical research.

[11]  K. Heilmann,et al.  Loss of differentiation in intestinal metaplasia in cancerous stomachs. A comparative morphologic study. , 1979, Pathology, research and practice.

[12]  P. Laurén,et al.  THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. , 1965, Acta pathologica et microbiologica Scandinavica.

[13]  I. Mackay,et al.  Simple atrophic gastritis and gastric carcinoma , 1971, Gut.

[14]  S. Kuikka,et al.  A theory to the stochastic dynamic model building for chronic progressive disease processes with an application to chronic gastritis. , 1976, Journal of theoretical biology.

[15]  S. Eriksson,et al.  Pernicious anemia as a risk factor in gastric cancer. The extent of the problem. , 2009, Acta medica Scandinavica.

[16]  B. Morson,et al.  Intestinal Metaplasia of the Gastric Mucosa , 1955, British Journal of Cancer.

[17]  P. Laurén,et al.  On the role of heterotopias of the intestinal epithelium in the pathogenesis of gastric cancer. , 2009, Acta pathologica et microbiologica Scandinavica.

[18]  A. Gad.  A histochemical study of human alimentary tract mucosubstances in health and disease. I. Normal and tumours. , 1969, British Journal of Cancer.

[19]  H. Goldman,et al.  Fine structure of intestinal metaplasia and adenocarcinoma of the human stomach. , 1968, Laboratory investigation; a journal of technical methods and pathology.

[20]  R. C. Connelly.  Atrophic gastritis. , 1949, Journal - Michigan State Medical Society.

[21]  G. Stemmermann,et al.  Intestinal metaplasia of the gastric mucosa: a gross and microscopic study of its distribution in various disease states. , 1968, Journal of the National Cancer Institute.

[22]  T. Larmi,et al.  Histochemistry of three dehydrogenase systems in cancerous and non-cancerous human stomachs with special reference to intestinal metaplasia. , 2009, Acta pathologica et microbiologica Scandinavica.

[23]  Turner Cn,et al.  ATROPHIC GASTRITIS : A FIVE–YEAR SURVEY OF THIRTY‐TWO CASES PROVEN BY GASTRIC BIOPSY , 1955, The Medical journal of Australia.

[24]  P. Sipponen,et al.  Gastric polyps; their morphological and endoscopical characteristics and relation to gastric carcinoma. , 2009, Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology.

[25]  H. Planteydt,et al.  Enzyme histochemistry of the human stomach, with spcial reference to intestinal metaplasia. , 1960, The Journal of pathology and bacteriology.

[26]  N. Muñoz,et al.  Histologic types of gastric carcinoma in high‐ and low‐risk areas , 1968, International journal of cancer.

[27]  P. Sipponen,et al.  Atrophic chronic gastritis and intestinal metaplasia in gastric carcinoma. Comparison with a representative population sample , 1983, Cancer.

[28]  M. Siurala,et al.  Long-term follow-up of subjects with superficial gastritis or a normal gastric mucosa. , 1971, Scandinavian journal of gastroenterology.

[29]  P. Sipponen,et al.  INTESTINAL METAPLASIA WITH COLONIC‐TYPE SULPHOMUCINS IN THE GASTRIC MUCOSA; ITS ASSOCIATION WITH GASTRIC CARCINOMA , 1980, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.