N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer
暂无分享,去创建一个
[1] M. Takeichi,et al. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. , 1988, Development.
[2] B. Geiger,et al. Cleavage of A-CAM by endogenous proteinases in cultured lens cells and in developing chick embryos. , 1990, Developmental biology.
[3] M. Caligiuri,et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice , 1994, Nature.
[4] F. Walsh,et al. Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin , 1994, Neuron.
[5] Peter D. Kwong,et al. Structural basis of cell-cell adhesion by cadherins , 1995, Nature.
[6] M. Herlyn,et al. Shifts in cadherin profiles between human normal melanocytes and melanomas. , 1996, The journal of investigative dermatology. Symposium proceedings.
[7] T. Carey,et al. Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion , 1996, The Journal of cell biology.
[8] P. Lansdorp,et al. Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia. , 1996, Blood.
[9] E. Voura,et al. Role of cadherins in the transendothelial migration of melanoma cells in culture. , 1997, Cell motility and the cytoskeleton.
[10] B. Gumbiner,et al. Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function , 1997, Current Biology.
[11] K. Knudsen,et al. N-cadherin promotes the commitment and differentiation of skeletal muscle precursor cells. , 1997, Developmental biology.
[12] R. Hynes,et al. Developmental defects in mouse embryos lacking N-cadherin. , 1997, Developmental biology.
[13] B. Geiger,et al. Inhibition of β-catenin-mediated transactivation by cadherin derivatives , 1998 .
[14] Gerhard Christofori,et al. A causal role for E-cadherin in the transition from adenoma to carcinoma , 1998, Nature.
[15] B. Geiger,et al. Inhibition of beta-catenin-mediated transactivation by cadherin derivatives. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[16] Keith R. Johnson,et al. N-Cadherin Promotes Motility in Human Breast Cancer Cells Regardless of Their E-Cadherin Expression , 1999, The Journal of cell biology.
[17] Paul Polakis,et al. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors , 1999, Oncogene.
[18] J. Schalken,et al. Cadherin switching in human prostate cancer progression. , 2000, Cancer research.
[19] K. Sass,et al. N-Cadherin Extracellular Repeat 4 Mediates Epithelial to Mesenchymal Transition and Increased Motility , 2000, The Journal of cell biology.
[20] O. Blaschuk,et al. A Novel Family of Cyclic Peptide Antagonists Suggests That N-cadherin Specificity Is Determined by Amino Acids That Flank the HAV Motif* , 2000, The Journal of Biological Chemistry.
[21] Stuart A. Aaronson,et al. Exogenous Expression of N-Cadherin in Breast Cancer Cells Induces Cell Migration, Invasion, and Metastasis , 2000, The Journal of cell biology.
[22] David R. Colman,et al. Molecular Modification of N-Cadherin in Response to Synaptic Activity , 2000, Neuron.
[23] G. Christofori,et al. N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling , 2001, Nature Cell Biology.
[24] S. Armeanu,et al. N-cadherin is developmentally regulated and functionally involved in early hematopoietic cell differentiation. , 2001, Journal of cell science.
[25] M. Gimbrone,et al. Molecular Events in Transmembrane Signaling via E-selectin , 2001, The Journal of Biological Chemistry.
[26] S. Skaper,et al. Identification of an N-cadherin Motif That Can Interact with the Fibroblast Growth Factor Receptor and Is Required for Axonal Growth* , 2001, The Journal of Biological Chemistry.
[27] K Satyamoorthy,et al. N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. , 2001, Cancer research.
[28] R. Hazan,et al. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. , 2002, Cancer cell.
[29] Yusuke Nakamura,et al. Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers , 2002, Oncogene.
[30] N. Tran,et al. Signal Transduction from N-cadherin Increases Bcl-2 , 2002, The Journal of Biological Chemistry.
[31] A. Blangy,et al. N-cadherin–dependent cell–cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts , 2002, The Journal of cell biology.
[32] Albert B. Reynolds,et al. A core function for p120-catenin in cadherin turnover , 2003, The Journal of cell biology.
[33] Tony Reiman,et al. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. , 2003, Blood.
[34] Eva M. Kovacs,et al. Direct cadherin-activated cell signaling , 2003, The Journal of cell biology.
[35] G. Morgan,et al. A Global Expression-based Analysis of the Consequences of the t(4;14) Translocation in Myeloma , 2004, Clinical Cancer Research.
[36] S. Hanks,et al. Roles played by a subset of integrin signaling molecules in cadherin-based cell–cell adhesion , 2004, The Journal of cell biology.
[37] R. Proia,et al. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. , 2004, Genes & development.
[38] R. Nusse,et al. Convergence of Wnt, ß-Catenin, and Cadherin Pathways , 2004, Science.
[39] O. Blaschuk,et al. Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling. , 2004, Experimental cell research.
[40] R. Nusse,et al. Convergence of Wnt, beta-catenin, and cadherin pathways. , 2004, Science.
[41] R. Hazan,et al. Cadherin Switch in Tumor Progression , 2004, Annals of the New York Academy of Sciences.
[42] M. Imamura,et al. N-Cadherin Expression and Epithelial-Mesenchymal Transition in Pancreatic Carcinoma , 2004, Clinical Cancer Research.
[43] Robert Moore,et al. N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis. , 2005, Experimental cell research.
[44] Keith R. Johnson,et al. Effect of N‐cadherin misexpression by the mammary epithelium in mice , 2005, Journal of cellular biochemistry.
[45] A. Echarri,et al. Integrin regulation of membrane domain trafficking and Rac targeting. , 2005, Biochemical Society transactions.
[46] J. Lilien,et al. The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. , 2005, Current opinion in cell biology.
[47] J. Keats,et al. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. , 2005, Blood.
[48] N. Chen,et al. Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway. , 2005, Molecular biology of the cell.
[49] O. Harrison,et al. The mechanism of cell adhesion by classical cadherins: the role of domain 1 , 2005, Journal of Cell Science.
[50] O. De Wever,et al. Soluble N‐cadherin in human biological fluids , 2006, International journal of cancer.
[51] B. Aronow,et al. beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer. , 2006, Cancer research.
[52] C. Heizmann,et al. The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer. , 2006, Gastroenterology.
[53] A. Trumpp,et al. Bone-marrow haematopoietic-stem-cell niches , 2006, Nature Reviews Immunology.
[54] Gareth Williams,et al. The Fibroblast Growth Factor Receptor Acid Box Is Essential for Interactions with N-Cadherin and All of the Major Isoforms of Neural Cell Adhesion Molecule*♦ , 2006, Journal of Biological Chemistry.
[55] D. Becker,et al. The role of N-Cadherin, MCAM, and β3 integrin in melanoma progression, proliferation, migration and invasion , 2006, Cancer biology & therapy.
[56] Jianfei Qi,et al. Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells. , 2005, Molecular biology of the cell.
[57] H. Wallerand,et al. N-Cadherin as a Novel Prognostic Marker of Progression in Superficial Urothelial Tumors , 2006, Clinical Cancer Research.
[58] D. Scadden,et al. The hematopoietic stem cell in its place , 2006, Nature Immunology.
[59] J. Huot,et al. Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases , 2006, Oncogene.
[60] Pascal Silberzan,et al. Traction forces exerted through N‐cadherin contacts , 2006, Biology of the cell.
[61] M. Hollingsworth,et al. Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. , 2006, Cancer research.
[62] J. Dick,et al. Targeting of CD44 eradicates human acute myeloid leukemic stem cells , 2006, Nature Medicine.
[63] N. Heisterkamp,et al. Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells , 2007, Leukemia.
[64] W. Weis,et al. Structure and mechanism of cadherins and catenins in cell-cell contacts. , 2007, Annual review of cell and developmental biology.
[65] W. Figg,et al. ADH1, an N-cadherin inhibitor, evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer , 2007, Anti-cancer drugs.
[66] M. Lisanti,et al. N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation. , 2007, Cancer research.
[67] L. Kèlland. Drug evaluation: ADH-1, an N-cadherin antagonist targeting cancer vascularization. , 2007, Current opinion in molecular therapeutics.
[68] A. Yap,et al. Not so simple: the complexity of phosphotyrosine signaling at cadherin adhesive contacts , 2007, Journal of Molecular Medicine.
[69] K. Gravdal,et al. A Switch from E-Cadherin to N-Cadherin Expression Indicates Epithelial to Mesenchymal Transition and Is of Strong and Independent Importance for the Progress of Prostate Cancer , 2007, Clinical Cancer Research.
[70] C. Favard,et al. Rac1 and RhoA GTPases have antagonistic functions during N‐cadherin‐dependent cell—cell contact formation in C2C12 myoblasts , 2007, Biology of the cell.
[71] E. Yu,et al. Neural cadherin overexpression is a predictive marker for early postoperative recurrence in hepatocellular carcinoma patients , 2008, Journal of gastroenterology and hepatology.
[72] R. Silverman-Gavrila,et al. Homotypic and Endothelial Cell Adhesions via N-Cadherin Determine Polarity and Regulate Migration of Vascular Smooth Muscle Cells , 2008, Circulation research.
[73] E. Verwiel,et al. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. , 2008, Cancer research.
[74] P. Febbo,et al. Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment. , 2008, Cancer research.
[75] Y. Shintani,et al. Cadherin switching , 2008, Journal of Cell Science.
[76] M. Hollingsworth,et al. ADH‐1 suppresses N‐cadherin‐dependent pancreatic cancer progression , 2008, International journal of cancer.
[77] O. Blaschuk,et al. Identification of a novel N-cadherin antagonist , 2008, Peptides.
[78] R. Arceci,et al. The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. , 2008, Blood.
[79] Angela C. Colmone,et al. Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells , 2008, Science.
[80] Chen Wang,et al. CD44v4 Is a Major E-Selectin Ligand that Mediates Breast Cancer Cell Transendothelial Migration , 2008, PloS one.
[81] W. Birchmeier,et al. Wnt signalling and its impact on development and cancer , 2008, Nature Reviews Cancer.
[82] C. Favard,et al. N-cadherin/p120 Catenin Association at Cell-Cell Contacts Occurs in Cholesterol-rich Membrane Domains and Is Required for RhoA Activation and Myogenesis* , 2009, The Journal of Biological Chemistry.
[83] S. Morrison,et al. Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. , 2009, Cell stem cell.
[84] R. Huang,et al. Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.
[85] M. Pierce,et al. Regulation of Homotypic Cell-Cell Adhesion by Branched N-Glycosylation of N-cadherin Extracellular EC2 and EC3 Domains* , 2009, The Journal of Biological Chemistry.
[86] S. M. Burden-Gulley,et al. Novel peptide mimetic small molecules of the HAV motif in N-cadherin inhibit N-cadherin-mediated neurite outgrowth and cell adhesion , 2009, Peptides.
[87] A. Mancuso,et al. Clinical and pharmacological phase I evaluation of Exherin (ADH-1), a selective anti-N-cadherin peptide in patients with N-cadherin-expressing solid tumours. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.
[88] M. Ross,et al. A phase 1 study of systemic ADH‐1 in combination with melphalan via isolated limb infusion in patients with locally advanced in‐transit malignant melanoma , 2009, Cancer.
[89] Z. Estrov,et al. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. , 2009, Blood.
[90] M. Parsons,et al. Collective Chemotaxis Requires Contact-Dependent Cell Polarity , 2010, Developmental cell.
[91] Q. Rao,et al. Enrichment of N-Cadherin and Tie2-bearing CD34+/CD38-/CD123+ leukemic stem cells by chemotherapy-resistance. , 2010, Cancer letters.
[92] Linheng Li,et al. Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow. , 2010, Cell stem cell.
[93] W. Birchmeier,et al. Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. , 2010, Cold Spring Harbor perspectives in biology.
[94] H. Wallerand,et al. Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines. , 2010, Urologic oncology.
[95] S. Horvath,et al. Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance , 2010, Nature Medicine.
[96] B. Katz,et al. Adhesion molecules--The lifelines of multiple myeloma cells. , 2010, Seminars in cancer biology.
[97] K. Jennbacken,et al. N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer. , 2010, Endocrine-related cancer.
[98] Robert A. Weinberg,et al. Tumor Metastasis: Molecular Insights and Evolving Paradigms , 2011, Cell.
[99] Stephanie Alexander,et al. Cancer Invasion and the Microenvironment: Plasticity and Reciprocity , 2011, Cell.
[100] M. Kersten,et al. N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation , 2011, Haematologica.
[101] Anant Chopra,et al. Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing. , 2011, American journal of physiology. Heart and circulatory physiology.
[102] S. Miyano,et al. N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells. , 2011, American journal of cancer research.
[103] A. Green,et al. The cadherin switch in ovarian high-grade serous carcinoma is associated with disease progression , 2011, Virchows Archiv.
[104] M. Quinn,et al. Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell‐like profile , 2011, Journal of cellular biochemistry.
[105] D. Leckband,et al. Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. , 2011, Physiological reviews.
[106] H. Miyake,et al. Expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract is associated with disease recurrence in patients undergoing nephroureterectomy. , 2011, Urology.
[107] H. Kuwano,et al. E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma , 2011, British Journal of Cancer.
[108] B. Honig,et al. The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. , 2011, Structure.
[109] Merrick I Ross,et al. Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[110] S. Persad,et al. Cadherin switch from E‐ to N‐cadherin in melanoma progression is regulated by the PI3K/PTEN pathway through Twist and Snail , 2012, The British journal of dermatology.
[111] H. Miyake,et al. Expression profile of E-cadherin and N-cadherin in non-muscle-invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection. , 2012, Urologic oncology.
[112] J. Vadgama,et al. Expression of Wnt3 Activates Wnt/β-Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells , 2012, Molecular Cancer Research.
[113] S. Yamada,et al. N-cadherin-mediated cell–cell adhesion promotes cell migration in a three-dimensional matrix , 2012, Journal of Cell Science.
[114] S. Natsugoe,et al. Clinical implications of N‐cadherin expression in gastric cancer , 2012, Pathology international.
[115] Konrad Basler,et al. The many faces and functions of β‐catenin , 2012, The EMBO journal.
[116] D. Link,et al. N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. , 2011, Blood.
[117] Li Li,et al. Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. , 2012, Cancer research.
[118] L. Calvi,et al. Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells. , 2012, Blood.
[119] I. Ghobrial,et al. Myeloma as a model for the process of metastasis: implications for therapy. , 2012, Blood.
[120] S. Batra,et al. MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1. , 2012, Carcinogenesis.
[121] A. Zannettino,et al. Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche? , 2012, Blood Cancer Journal.
[122] X. Yao,et al. Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma , 2012, OncoTargets and therapy.
[123] W. Fang,et al. Nuclear expression of N‐cadherin correlates with poor prognosis of nasopharyngeal carcinoma , 2012, Histopathology.
[124] A. Sudo,et al. Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors , 2013, BMC Cancer.
[125] F. Speleman,et al. N-Cadherin in Neuroblastoma Disease: Expression and Clinical Significance , 2012, PloS one.
[126] J. Li,et al. N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer , 2012, Oncogene.
[127] D. Leckband,et al. N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signaling pathways , 2013, Nature Communications.
[128] D. Jonker,et al. Phase I clinical trial of Exherin (ADH-1) in patients with advanced solid tumors. , 2013, Current clinical pharmacology.
[129] Zhaogang Dong,et al. N-Cadherin Expression Is Associated with Acquisition of EMT Phenotype and with Enhanced Invasion in Erlotinib-Resistant Lung Cancer Cell Lines , 2013, PloS one.
[130] S. Hamilton-Dutoit,et al. E‐ to N‐cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression , 2013, The British journal of dermatology.
[131] Xinming Chen,et al. Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: correlations with poor prognosis. , 2013, Oral oncology.
[132] Ming Li,et al. DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway , 2013, Molecular Cancer.
[133] Alexander Gheldof,et al. Cadherins and epithelial-to-mesenchymal transition. , 2013, Progress in molecular biology and translational science.
[134] Qian Ning,et al. Vascular Endothelial Growth Factor Receptor-1 Activation Promotes Migration and Invasion of Breast Cancer Cells through Epithelial-Mesenchymal Transition , 2013, PloS one.
[135] A. Yap,et al. Coordinating Rho and Rac: the regulation of Rho GTPase signaling and cadherin junctions. , 2013, Progress in molecular biology and translational science.
[136] A. Zannettino,et al. Circulating N‐cadherin levels are a negative prognostic indicator in patients with multiple myeloma , 2013, British journal of haematology.
[137] J. Kirshner,et al. N-cadherin impedes proliferation of the multiple myeloma cancer stem cells. , 2013, American journal of blood research.
[138] H Putter,et al. Expression of cell adhesion molecules and prognosis in breast cancer , 2013, The British journal of surgery.
[139] X. Qiu,et al. Prognostic Significance of Twist and N-Cadherin Expression in NSCLC , 2013, PloS one.
[140] S. Seok,et al. Interleukin-6-induced Twist and N-cadherin enhance melanoma cell metastasis , 2013, Melanoma research.
[141] G. Berx,et al. Regulatory networks defining EMT during cancer initiation and progression , 2013, Nature Reviews Cancer.
[142] H. Lee,et al. Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer. , 2013, Human pathology.
[143] E. Hsiao,et al. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. , 2013, Cell stem cell.
[144] D. Campana,et al. Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. , 2012, Blood.
[145] M. Loh,et al. Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. , 2013, Blood.
[146] I. Ellis,et al. Epithelial mesenchymal transition in early invasive breast cancer: an immunohistochemical and reverse phase protein array study , 2014, Breast Cancer Research and Treatment.
[147] Erqun Song,et al. CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE‐cadherin junction on metastatic melanoma cells , 2014, FEBS letters.
[148] L. Norton,et al. N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties , 2014, Oncogene.
[149] S. Etienne-Manneville,et al. Neighborly relations during collective migration. , 2014, Current opinion in cell biology.
[150] N. Ditsch,et al. Strong correlation between N-cadherin and CD133 in breast cancer: role of both markers in metastatic events , 2014, Journal of Cancer Research and Clinical Oncology.
[151] Jing-he Li,et al. N-cadherin and P-cadherin are biomarkers for invasion, metastasis, and poor prognosis of gallbladder carcinomas. , 2014, Pathology, research and practice.
[152] C. Streuli,et al. Signalling pathways linking integrins with cell cycle progression. , 2014, Matrix biology : journal of the International Society for Matrix Biology.
[153] Q. Rao,et al. N-Cadherin and Tie2 positive CD34⁺CD38⁻CD123⁺ leukemic stem cell populations can develop acute myeloid leukemia more effectively in NOD/SCID mice. , 2014, Leukemia research.
[154] T. Gauler,et al. Individual profiling of circulating tumor cell composition in patients with non-small cell lung cancer receiving platinum based treatment. , 2014, Translational lung cancer research.
[155] T. Gauler,et al. Detection of Circulating Tumor Cell Subpopulations in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC) , 2014, PloS one.
[156] Baoan Ma,et al. microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R , 2014, International journal of oncology.
[157] R. Davis,et al. Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance. , 2014, Blood.
[158] A. Ridley,et al. Rho GTPase signalling in cell migration , 2015, Current opinion in cell biology.
[159] M. Dewhirst,et al. Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. , 2015, Annals of surgery.
[160] Xuebing Yan,et al. N-cadherin, a novel prognostic biomarker, drives malignant progression of colorectal cancer. , 2015, Molecular medicine reports.
[161] M. Civera,et al. Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions. , 2015, Organic & biomolecular chemistry.
[162] K. Mrozik,et al. Therapeutic targeting of N‐cadherin is an effective treatment for multiple myeloma , 2015, British journal of haematology.
[163] L. R. Wasil,et al. Epstein–Barr virus LMP1 induces focal adhesions and epithelial cell migration through effects on integrin-α5 and N-cadherin , 2015, Oncogenesis.
[164] D. N. Watkins,et al. Hedgehog Signaling in the Maintenance of Cancer Stem Cells , 2015, Cancers.
[165] Ming Zhou,et al. Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance. , 2015, International journal of clinical and experimental medicine.
[166] I. Ellis,et al. Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification , 2015, Breast Cancer Research and Treatment.
[167] H. Rui,et al. Blocking the adhesion cascade at the premetastatic niche for prevention of breast cancer metastasis. , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.
[168] Andrew G. Clark,et al. Modes of cancer cell invasion and the role of the microenvironment. , 2015, Current opinion in cell biology.
[169] M. Deininger,et al. β-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia , 2015, Leukemia.
[170] D. Lombardo,et al. Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasion , 2015, British Journal of Cancer.
[171] W. Birchmeier,et al. New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals , 2015, Gut.
[172] Chin-Lee Wu,et al. Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells , 2015, Oncotarget.
[173] O. Blaschuk. N-cadherin antagonists as oncology therapeutics , 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.
[174] Shile Huang,et al. Understanding of leukemic stem cells and their clinical implications , 2017, Molecular Cancer.
[175] Z. Yao,et al. N‐Cadherin Aided in Maintaining the Characteristics of Leukemic Stem Cells , 2016, Anatomical record.
[176] K. Lidke,et al. Tetraspanin CD82 regulates bone marrow homing of acute myeloid leukemia by modulating the molecular organization of N-cadherin , 2015, Oncogene.
[177] Brent W. Weyers,et al. Deletion of the cytoplasmic domain of N-cadherin reduces, but does not eliminate, traction force-transmission. , 2016, Biochemical and biophysical research communications.
[178] T. Gauler,et al. Circulating Tumor Cell Composition in Renal Cell Carcinoma , 2016, PloS one.
[179] M. Andreeff,et al. Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang , 2016, Cancer biology & medicine.
[180] Brian D Cosgrove,et al. N-Cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells , 2016, Nature materials.
[181] T. Kohno,et al. LPP inhibits collective cell migration during lung cancer dissemination , 2016, Oncogene.
[182] Roberto Mayor,et al. The front and rear of collective cell migration , 2016, Nature Reviews Molecular Cell Biology.
[183] M. Dimopoulos,et al. Expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in localized prostate cancer. , 2016, Urologic oncology.
[184] R. Hruban,et al. N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN , 2015, Oncogene.
[185] Jianrong Lu,et al. Cancer cells remodel themselves and vasculature to overcome the endothelial barrier. , 2016, Cancer letters.
[186] Senlin Zhao,et al. FERMT1 mediates epithelial–mesenchymal transition to promote colon cancer metastasis via modulation of β-catenin transcriptional activity , 2017, Oncogene.
[187] Ruifeng Lu,et al. A central role for cadherin signaling in cancer. , 2017, Experimental cell research.
[188] S. Etienne-Manneville,et al. Single and collective cell migration: the mechanics of adhesions , 2017, Molecular biology of the cell.
[189] Q. Liao,et al. Overexpression of PAK1 Correlates with Aberrant Expression of EMT Markers and Poor Prognosis in Non-Small Cell Lung Cancer , 2017, Journal of Cancer.
[190] Ye Wang,et al. MicroRNA-199b-5p attenuates TGF-β1-induced epithelial–mesenchymal transition in hepatocellular carcinoma , 2017, British Journal of Cancer.
[191] M. Stack,et al. Cadherin Composition and Multicellular Aggregate Invasion In Organotypic Models of Epithelial Ovarian Cancer Intraperitoneal Metastasis , 2017, Oncogene.
[192] A. Nardini,et al. Clinical significance of epithelial‐to‐mesenchymal transition in laryngeal carcinoma: Its role in the different subsites , 2017, Head & neck.
[193] A. Fougerat,et al. Small GTPases orchestrate cell-cell communication during collective cell movement , 2020, Small GTPases.
[194] Yi-qing Wang,et al. Wnt3a Expression Is Associated with Epithelial-Mesenchymal Transition and Impacts Prognosis of Lung Adenocarcinoma Patients , 2017, Journal of Cancer.
[195] S. Natsugoe,et al. Clinical significance of altering epithelial–mesenchymal transition in metastatic lymph nodes of gastric cancer , 2017, Gastric Cancer.
[196] Jian Xu,et al. MiRNA-145 suppresses lung adenocarcinoma cell invasion and migration by targeting N-cadherin , 2017, Biotechnology Letters.
[197] D. Link,et al. N‐cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage–Specific , 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[198] D. Pirone,et al. Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell–endothelial cell-regulated barrier function , 2017, Proceedings of the National Academy of Sciences.
[199] A. Briganti,et al. Prognostic Role of N‐cadherin Expression in Patients With Invasive Bladder Cancer , 2017, Clinical genitourinary cancer.
[200] R. Kypta,et al. WNT signalling in prostate cancer , 2017, Nature Reviews Urology.
[201] R. Mayor,et al. Adjustable viscoelasticity allows for efficient collective cell migration , 2019, Seminars in cell & developmental biology.
[202] Yuzhu Hu,et al. Upregulated N‐cadherin expression is associated with poor prognosis in epithelial‐derived solid tumours: A meta‐analysis , 2018, European journal of clinical investigation.