Analysis of the composition, assembly kinetics and activity of native Apaf‐1 apoptosomes

[1]  J. Kofron,et al.  Distinctive Roles of PHAP Proteins and Prothymosin-α in a Death Regulatory Pathway , 2003, Science.

[2]  Mason R. Mackey,et al.  Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane , 2002, Cell.

[3]  P. McNamara,et al.  Regulation of Histone Acetylation and Transcription by Nuclear Protein pp32, a Subunit of the INHAT Complex* , 2002, The Journal of Biological Chemistry.

[4]  Xuejun Jiang,et al.  Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. , 2002, Molecular cell.

[5]  Seamus J. Martin,et al.  Apoptosis‐associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl‐2 , 2001, The EMBO journal.

[6]  A. Görg,et al.  Improved silver staining protocols for high sensitivity protein identification using matrix‐assisted laser desorption/ionization‐time of flight analysis , 2001, Proteomics.

[7]  A. Godzik,et al.  A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis* , 2001, The Journal of Biological Chemistry.

[8]  Colin Adrain,et al.  Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis* , 2001, The Journal of Biological Chemistry.

[9]  S. B. Bratton,et al.  Recruitment, activation and retention of caspases‐9 and ‐3 by Apaf‐1 apoptosome and associated XIAP complexes , 2001, The EMBO journal.

[10]  Xiaodong Wang,et al.  Cytochrome c Promotes Caspase-9 Activation by Inducing Nucleotide Binding to Apaf-1* , 2000, The Journal of Biological Chemistry.

[11]  S. Srinivasula,et al.  Negative regulation of cytochrome c‐mediated oligomerization of Apaf‐1 and activation of procaspase‐9 by heat shock protein 90 , 2000, The EMBO journal.

[12]  Dick D. Mosser,et al.  Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome , 2000, Nature Cell Biology.

[13]  Emad S. Alnemri,et al.  Negative regulation of the Apaf-1 apoptosome by Hsp70 , 2000, Nature Cell Biology.

[14]  Robert L Moritz,et al.  Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins , 2000, Cell.

[15]  Xiaodong Wang,et al.  Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition , 2000, Cell.

[16]  E. Cheng,et al.  Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1. , 2000, Molecular cell.

[17]  Gail Walker,et al.  Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes* , 2000, The Journal of Biological Chemistry.

[18]  Y. Lazebnik,et al.  Caspase-9 and APAF-1 form an active holoenzyme. , 1999, Genes & development.

[19]  H. Stennicke,et al.  Catalytic properties of the caspases , 1999, Cell Death and Differentiation.

[20]  G. Cohen,et al.  Caspase Activation Involves the Formation of the Aposome, a Large (∼700 kDa) Caspase-activating Complex* , 1999, The Journal of Biological Chemistry.

[21]  Seamus J. Martin,et al.  Regulation of Apoptotic Protease Activating Factor-1 Oligomerization and Apoptosis by the WD-40 Repeat Region* , 1999, The Journal of Biological Chemistry.

[22]  J. Rebel,et al.  Identification of Sequences Required for Inhibition of Oncogene-mediated Transformation by pp32* , 1999, The Journal of Biological Chemistry.

[23]  X. Liu,et al.  An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9* , 1999, The Journal of Biological Chemistry.

[24]  Emad S. Alnemri,et al.  Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner , 1999, The Journal of cell biology.

[25]  V. Dixit,et al.  Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex* , 1998, The Journal of Biological Chemistry.

[26]  S. Srinivasula,et al.  Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade , 1997, Cell.

[27]  G M Cohen,et al.  Caspases: the executioners of apoptosis. , 1997, The Biochemical journal.

[28]  Guy S. Salvesen,et al.  X-linked IAP is a direct inhibitor of cell-death proteases , 1997, Nature.

[29]  S. Pfeffer,et al.  Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[30]  D. Green,et al.  The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.

[31]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[32]  G. Pasternack,et al.  Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci. , 1996, Molecular biology of the cell.

[33]  Z. Damuni,et al.  Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. , 1996, Biochemistry.

[34]  D. Danley,et al.  D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis (*) , 1996, Journal of Biological Chemistry.

[35]  D. Green,et al.  The cytotoxic cell protease granzyme B initiates apoptosis in a cell‐free system by proteolytic processing and activation of the ICE/CED‐3 family protease, CPP32, via a novel two‐step mechanism. , 1996, The EMBO journal.

[36]  Seamus J. Martin,et al.  Protease activation during apoptosis: Death by a thousand cuts? , 1995, Cell.

[37]  J. Kofron,et al.  Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. , 2003, Science.

[38]  G. Salvesen,et al.  Caspase activation. , 2003, Biochemical Society symposium.

[39]  G M Cohen,et al.  Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. , 2000, The Journal of biological chemistry.

[40]  G. Cohen,et al.  Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. , 1999, The Journal of biological chemistry.