Effects of progesterone on human astrocytoma progression

Los gliomas son los tumores cerebrales primarios mas frecuentes en la poblacion mundial. Los astrocitomas son el tipo mas comun de glioma, constituyen el 76% de estos tumores y la Organizacion Mundial de la Salud los ha clasificado en 4 grados (I-IV) de acuerdo a sus caracteristicas histologicas, siendo los de grado IV los mas agresivos. Se ha informado que la progesterona (P) promueve la proliferacion, migracion e invasion celulares en los astrocitomas humanos a traves de la interaccion con su receptor intracelular (RP), el cual es un factor de transcripcion activado por su ligando que esta involucrado en la regulacion de genes relacionados con el control del ciclo celular y la metastasis. La expresion del RP en los astrocitomas esta directamente relacionada con el grado de evolucion del tumor, lo que sugiere que los tumores que expresan al RP presentan un fuerte potencial oncogenico. En esta revision se presenta un panorama general acerca del papel de la P en el desarrollo y progresion de los astrocitomas humanos

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