Protecting microRNAs from RNase degradation with steric DNA nanostructures† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc01829g Click here for additional data file.

A DNA nanostructure bearing a “Shuriken” shape is designed to deliver, protect and activate microRNA-145 functionality in human colorectal cancer cells. This novel DNA nanostructure enabled therapeutic platform greatly suppresses cancer cell proliferation and tumor growth.

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