On-chip micromanipulation and assembly of colloidal particles by electric fields.

We overview the ways in which electric fields can be used for on-chip manipulation and assembly of colloidal particles. Particles suspended in water readily respond to alternating (AC) or direct current (DC) electric fields. Charged particles in DC fields are moved towards oppositely charged electrodes by electrophoresis. Dielectrophoresis, particle mobility in AC fields, allows precise manipulation of particles through a range of parameters including field strength and frequency and electrode geometry. Simultaneously, DC or AC electrokinetics may drive liquid flows inside the experimental cells, which also leads to transport and redistribution of the suspended particles. Examples of dielectrophoretic manipulation and assembly of nanoparticles and microparticles by planar on-chip electrodes are presented. The structures assembled include conductive microwires from metallic nanoparticles and switchable two-dimensional crystals from polymer microspheres. We also discuss how dielectrophoresis and AC electrokinetics can be used in droplet-based microfluidic chips, biosensors, and devices for collection of particles from diluted suspensions.

[1]  V. R. Raju,et al.  Paper-like electronic displays: Large-area rubber-stamped plastic sheets of electronics and microencapsulated electrophoretic inks , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[2]  W. D. de Heer,et al.  Carbon Nanotubes--the Route Toward Applications , 2002, Science.

[3]  D. Scott,et al.  Assembly of colloidal particles into microwires using an alternating electric field. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[4]  Hiroyuki Fujita,et al.  Positioning living cells on a high-density electrode array by negative dielectrophoresis , 2003 .

[5]  N. Decoster,et al.  AC field induced two-dimensional aggregation of multilamellar vesicles , 1998 .

[6]  Castellanos,et al.  Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. I. Experimental measurements , 2000, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[7]  P. Sides Electrohydrodynamic Particle Aggregation on an Electrode Driven by an Alternating Electric Field Normal to It , 2001 .

[8]  Burçak Alp,et al.  Construction of biofilms with defined internal architecture using dielectrophoresis and flocculation. , 2003, Biotechnology and bioengineering.

[9]  Lee R. White,et al.  Electrophoretic mobility of a spherical colloidal particle , 1978 .

[10]  Thomas B. Jones,et al.  Size-selective deposition of particles combining liquid and particulate dielectrophoresis , 2005 .

[11]  Castellanos,et al.  Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. II. A linear double-layer analysis , 2000, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[12]  Howard A. Stone,et al.  ENGINEERING FLOWS IN SMALL DEVICES , 2004 .

[13]  Michael P. Hughes,et al.  AC electrokinetics: applications for nanotechnology , 2000 .

[14]  Cheng,et al.  Hydrogen storage in single-walled carbon nanotubes at room temperature , 1999, Science.

[15]  Thomas B. Jones,et al.  Electromechanics of Particles , 1995 .

[16]  J. E. Mattson,et al.  A Group-IV Ferromagnetic Semiconductor: MnxGe1−x , 2002, Science.

[17]  Seiji Akita,et al.  RAPID COMMUNICATION: Orientation and purification of carbon nanotubes using ac electrophoresis , 1998 .

[18]  J. Fagan,et al.  Vertical Oscillatory Motion of a Single Colloidal Particle Adjacent to an Electrode in an ac Electric Field , 2002 .

[19]  Murat Okandan,et al.  Combined field-induced dielectrophoresis and phase separation for manipulating particles in microfluidics , 2003 .

[20]  Joonwon Kim,et al.  Electrostatic actuation of microscale liquid-metal droplets , 2002 .

[21]  O. Velev,et al.  Control and modeling of the dielectrophoretic assembly of on-chip nanoparticle wires. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[22]  Hong Lin,et al.  Electrophoretic deposition and optical property of titania nanotubes films , 2006 .

[23]  Tomas Bergman,et al.  Microfluidic electrocapture for separation of peptides. , 2005, Analytical chemistry.

[24]  Janko Auerswald,et al.  Quantitative assessment of dielectrophoresis as a micro fluidic retention and separation technique for beads and human blood erythrocytes , 2003 .

[25]  Frederick F Becker,et al.  Microsample preparation by dielectrophoresis: isolation of malaria. , 2002, Lab on a chip.

[26]  Dominik P. J. Barz,et al.  Model and verification of electrokinetic flow and transport in a micro-electrophoresis device. , 2005, Lab on a chip.

[27]  M. Washizu Electrostatic actuation of liquid droplets for micro-reactor applications , 1997 .

[28]  M. Hon,et al.  Effect of colloid characteristics on the fabrication of ZnO nanowire arrays by electrophoretic deposition , 2002 .

[29]  M. Mpholo,et al.  Low voltage plug flow pumping using anisotropic electrode arrays , 2003 .

[30]  J. Fagan,et al.  Evidence of multiple electrohydrodynamic forces acting on a colloidal particle near an electrode due to an alternating current electric field. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[31]  Hsueh-Chia Chang,et al.  Manipulation and characterization of red blood cells with alternating current fields in microdevices , 2003, Electrophoresis.

[32]  P. Gascoyne,et al.  Droplet-based chemistry on a programmable micro-chip. , 2004, Lab on a chip.

[33]  P. Sides Calculation of Electrohydrodynamic Flow around a Single Particle on an Electrode , 2003 .

[34]  R. Westervelt,et al.  Dielectrophoretic manipulation of drops for high-speed microfluidic sorting devices , 2006 .

[35]  O. Velev,et al.  Dielectrophoretic assembly of oriented and switchable two-dimensional photonic crystals , 2003 .

[36]  O. Velev,et al.  Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors , 2004, Nature materials.

[37]  S G Shirley,et al.  Dielectrophoretic sorting of particles and cells in a microsystem. , 1998, Analytical chemistry.

[38]  Paul E. Laibinis,et al.  Directed Movement of Liquids on Patterned Surfaces Using Noncovalent Molecular Adsorption , 2000 .

[39]  A. Ajdari,et al.  Pumping liquids using asymmetric electrode arrays , 2000, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[40]  W. Fritzsche,et al.  Electrical Classification of the Concentration of Bioconjugated Metal Colloids after Surface Adsorption and Silver Enhancement , 2001 .

[41]  R. Fair,et al.  Electrowetting-based actuation of droplets for integrated microfluidics. , 2002, Lab on a chip.

[42]  J. Eijkel,et al.  An AC electroosmotic micropump for circular chromatographic applications. , 2004, Lab on a chip.

[43]  Paul Mulvaney,et al.  Preparation of ordered colloid monolayers by electrophoretic deposition , 1993 .

[44]  Hsueh-Chia Chang,et al.  Long-Range AC Electroosmotic Trapping and Detection of Bioparticles , 2005 .

[45]  K. Kaler,et al.  A novel dielectrophoresis-based device for the selective retention of viable cells in cell culture media. , 1997, Biotechnology and bioengineering.

[46]  R. Pethig,et al.  Transverse dipolar chaining in binary suspensions induced by rf fields , 1999 .

[47]  Electric Field-Reversible Three-Dimensional Colloidal Crystals , 2003 .

[48]  A. Ajdari,et al.  Electrically induced flows in the vicinity of a dielectric stripe on a conducting plane , 2002, The European physical journal. E, Soft matter.

[49]  D. Marr,et al.  Two-Dimensional Electrohydrodynamically Induced Colloidal Phases , 2002 .

[50]  B Wagner,et al.  Levitation, holding, and rotation of cells within traps made by high-frequency fields. , 1992, Biochimica et biophysica acta.

[51]  Castellanos,et al.  AC Electric-Field-Induced Fluid Flow in Microelectrodes. , 1999, Journal of colloid and interface science.

[52]  O. Kurosawa,et al.  Quantitative analysis of DNA orientation in stationary AC electric field using fluorescence anisotropy , 1995, IAS '95. Conference Record of the 1995 IEEE Industry Applications Conference Thirtieth IAS Annual Meeting.

[53]  H. Morgan,et al.  Electrohydrodynamics and dielectrophoresis in microsystems: scaling laws , 2003 .

[54]  Miguel Holgado,et al.  Electrophoretic Deposition To Control Artificial Opal Growth , 1999 .

[55]  Bernhard Wagner,et al.  Radio-frequency microtools for particle and live cell manipulation , 1994, Naturwissenschaften.

[56]  S. Guelcher,et al.  Two-particle dynamics on an electrode in ac electric fields. , 2002, Advances in Colloid and Interface Science.

[57]  Ronald Pethig,et al.  Positive and negative dielectrophoretic collection of colloidal particles using interdigitated castellated microelectrodes , 1992 .

[58]  George M. Whitesides,et al.  How to Make Water Run Uphill , 1992, Science.

[59]  M. Mcdonnell,et al.  RAPID COMMUNICATION: Use of combined dielectrophoretic/electrohydrodynamic forces for biosensor enhancement , 2003 .

[60]  Hiroyuki Ohshima,et al.  Henry's Function for Electrophoresis of a Cylindrical Colloidal Particle , 1996 .

[61]  Masao Washizu,et al.  Applications of electrostatic stretch-and-positioning of DNA , 1993, Conference Record of the 1993 IEEE Industry Applications Conference Twenty-Eighth IAS Annual Meeting.

[62]  David W. M. Marr,et al.  Electrically Switchable Colloidal Ordering in Confined Geometries , 2001 .

[63]  Osamu Sato,et al.  Fabrication of structured porous film by electrophoresis [2] , 2001 .

[64]  Wim Rutten,et al.  Understanding dielectrophoretic trapping of neuronal cells: modelling electric field, electrode-liquid interface and fluid flow , 2002 .

[65]  C. R. Martin,et al.  Carbon nanotubule membranes for electrochemical energy storage and production , 1998, Nature.

[66]  R. J. Hunter Foundations of Colloid Science , 1987 .

[67]  P. Burke,et al.  Electronic manipulation of DNA, proteins, and nanoparticles for potential circuit assembly. , 2004, Biosensors & bioelectronics.

[68]  大房 健 基礎講座 電気泳動(Electrophoresis) , 2005 .

[69]  I. Hsing,et al.  An improved anodic bonding process using pulsed voltage technique , 2000, Journal of Microelectromechanical Systems.

[70]  Hsueh-Chia Chang,et al.  A new electro-osmotic pump based on silica monoliths , 2006 .

[71]  A. Ajdari,et al.  Electrically induced interactions between colloidal particles in the vicinity of a conducting plane. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[72]  Ichimura,et al.  Light-driven motion of liquids on a photoresponsive surface , 2000, Science.

[73]  Junya Suehiro,et al.  Dielectrophoretic filter for separation and recovery of biological cells in water , 2003 .

[74]  C. Mirkin,et al.  Array-Based Electrical Detection of DNA with Nanoparticle Probes , 2002, Science.

[75]  S. Cho,et al.  Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits , 2003 .

[76]  L. White,et al.  Effects of stern-layer conductance on electrokinetic transport properties of colloidal particles , 1990 .

[77]  Masao Washizu,et al.  Dielectrophoretic detection of molecular bindings , 2000, Conference Record of the 2000 IEEE Industry Applications Conference. Thirty-Fifth IAS Annual Meeting and World Conference on Industrial Applications of Electrical Energy (Cat. No.00CH37129).

[78]  Wolfgang Fritzsche,et al.  Pearl chain formation of nanoparticles in microelectrode gaps by dielectrophoresis. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[79]  P. Alivisatos The use of nanocrystals in biological detection , 2004, Nature Biotechnology.

[80]  John L. Anderson,et al.  Particle Clustering and Pattern Formation during Electrophoretic Deposition: A Hydrodynamic Model , 1997 .

[81]  N. Manaresi,et al.  A CMOS chip for individual cell manipulation and detection , 2003, 2003 IEEE International Solid-State Circuits Conference, 2003. Digest of Technical Papers. ISSCC..

[82]  Ryan J. Kershner,et al.  The role of electrochemical reactions during electrophoretic particle deposition. , 2004, Journal of colloid and interface science.

[83]  Jun Zeng,et al.  Principles of droplet electrohydrodynamics for lab-on-a-chip. , 2004, Lab on a chip.

[84]  J. W. Parce,et al.  Electrokinetically controlled microfluidic analysis systems. , 2000, Annual review of biophysics and biomolecular structure.

[85]  Hongjie Dai,et al.  Functionalized Carbon Nanotubes for Molecular Hydrogen Sensors , 2001 .

[86]  T. Jones,et al.  Dielectrophoretic liquid actuation and nanodroplet formation , 2001 .

[87]  D. Weitz,et al.  Geometrically mediated breakup of drops in microfluidic devices. , 2003, Physical review letters.

[88]  H. Stone,et al.  Microfluidics: Basic issues, applications, and challenges , 2001 .

[89]  Zhiyong Tang,et al.  One‐Dimensional Assemblies of Nanoparticles: Preparation, Properties, and Promise , 2005 .

[90]  Fabrication of nanometer-spaced electrodes using gold nanoparticles , 2002, cond-mat/0211213.

[91]  P. A. Smith,et al.  Electric-field assisted assembly and alignment of metallic nanowires , 2000 .

[92]  M. Bazant,et al.  Induced-charge electrokinetic phenomena: theory and microfluidic applications. , 2003, Physical review letters.

[93]  D. A. Saville,et al.  Field-Induced Layering of Colloidal Crystals , 1996, Science.

[94]  O. Velev,et al.  Dielectrophoretic Assembly of Electrically Functional Microwires from Nanoparticle Suspensions , 2001, Science.

[95]  T. Jones Liquid dielectrophoresis on the microscale , 2001 .

[96]  J. Fagan,et al.  Vertical motion of a charged colloidal particle near an AC polarized electrode with a nonuniform potential distribution: theory and experimental evidence. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[97]  Vanessa Brisson,et al.  Self-assembly and two-dimensional patterning of cell arrays by electrophoretic deposition. , 2002, Biotechnology and bioengineering.

[98]  L. White,et al.  Calculation of the electric polarizability of a charged spherical dielectric particle by the theory of colloidal electrokinetics. , 2005, Journal of colloid and interface science.

[99]  Y. Huang,et al.  Differences in the AC electrodynamics of viable and non-viable yeast cells determined through combined dielectrophoresis and electrorotation studies. , 1992, Physics in medicine and biology.

[100]  O. Velev,et al.  Two-dimensional crystallization of microspheres by a coplanar AC electric field. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[101]  Chih-Ming Ho,et al.  Electrokinetic bioprocessor for concentrating cells and molecules. , 2004, Analytical chemistry.

[102]  J. Gilman,et al.  Nanotechnology , 2001 .

[103]  Sonia Grego,et al.  An AC electrokinetic technique for collection and concentration of particles and cells on patterned electrodes. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[104]  O. Park,et al.  The fabrication of micropatterns of a 2D colloidal assembly by electrophoretic deposition , 2006 .

[105]  Joseph T. Hupp,et al.  Assembly of Micropatterned Colloidal Gold Thin Films via Microtransfer Molding and Electrophoretic Deposition , 2000 .

[106]  E. Braun,et al.  DNA-templated assembly and electrode attachment of a conducting silver wire , 1998, Nature.

[107]  A. Ajdari Electrokinetic ‘ratchet’ pumps for microfluidics , 2002 .

[108]  J. Voldman,et al.  Dielectrophoretic registration of living cells to a microelectrode array. , 2004, Biosensors & bioelectronics.

[109]  Hsueh-Chia Chang,et al.  Microfluidic mixing by dc and ac nonlinear electrokinetic vortex flows , 2004 .

[110]  Hongjie Dai,et al.  Carbon nanotubes: opportunities and challenges , 2002 .

[111]  J. Prost,et al.  Two-dimensional aggregation and crystallization of a colloidal suspension of latex spheres , 1984 .

[112]  Hao Zhou,et al.  Calculation of the dynamic impedance of the double layer on a planar electrode by the theory of electrokinetics. , 2005, Journal of colloid and interface science.

[113]  A. Boccaccini Editorial: Electrophoretic deposition: fundamentals and applications in materials science , 2004 .

[114]  T. Fujii,et al.  Handling of Picoliter Liquid Samples in a Poly(dimethylsiloxane)-Based Microfluidic Device , 1999 .

[115]  Masao Washizu,et al.  Molecular dielectrophoresis of bio-polymers , 1992, Conference Record of the 1992 IEEE Industry Applications Society Annual Meeting.

[116]  O. Velev,et al.  Evaporation-induced particle microseparations inside droplets floating on a chip. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[117]  G. van den Engh,et al.  Trapping of DNA by dielectrophoresis , 2002, Electrophoresis.

[118]  Junya Suehiro,et al.  Selective detection of viable bacteria using dielectrophoretic impedance measurement method , 2003 .

[119]  M. A. Bevan,et al.  Aggregation Dynamics for Two Particles during Electrophoretic Deposition under Steady Fields , 2000 .

[120]  M. Gao,et al.  Electric field directed layer-by-layer assembly of highly fluorescent CdTe nanoparticles. , 2001, Journal of nanoscience and nanotechnology.

[121]  Y. Huang,et al.  Introducing dielectrophoresis as a new force field for field-flow fractionation. , 1997, Biophysical journal.

[122]  Hsueh-Chia Chang,et al.  Electrokinetic mixing vortices due to electrolyte depletion at microchannel junctions. , 2003, Journal of colloid and interface science.

[123]  M. Washizu,et al.  Electrostatic manipulation of DNA in microfabricated structures , 1989, Conference Record of the IEEE Industry Applications Society Annual Meeting,.

[124]  Mathieu Allard,et al.  In situ study of colloid crystallization in constrained geometry. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[125]  H. A. Pohl,et al.  Separation of Living and Dead Cells by Dielectrophoresis , 1966, Science.

[126]  Xinqi Chen,et al.  Aligning single-wall carbon nanotubes with an alternating-current electric field , 2001 .

[127]  Chia-Fu Chou,et al.  Electrodeless dielectrophoresis of single- and double-stranded DNA. , 2002, Biophysical journal.

[128]  Hsueh-Chia Chang,et al.  STATIC AND SPONTANEOUS ELECTROWETTING , 2005 .

[129]  Thomas B. Jones,et al.  On the Relationship of Dielectrophoresis and Electrowetting , 2002 .

[130]  Hsueh-Chia Chang,et al.  Electrokinetic transport of red blood cells in microcapillaries , 2002, Electrophoresis.

[131]  H. Stone,et al.  Formation of dispersions using “flow focusing” in microchannels , 2003 .

[132]  Ilhan A. Aksay,et al.  Assembly of Colloidal Crystals at Electrode Interfaces , 1997 .

[133]  Orlin D. Velev,et al.  In situ assembly of colloidal particles into miniaturized biosensors , 1999 .

[134]  Heiko B. Weber,et al.  Simultaneous Deposition of Metallic Bundles of Single-walled Carbon Nanotubes Using Ac-dielectrophoresis , 2003 .

[135]  C. Kim,et al.  Surface-tension-driven microactuation based on continuous electrowetting , 2000, Journal of Microelectromechanical Systems.

[136]  M. Bazant,et al.  Induced-charge electro-osmosis , 2003, Journal of Fluid Mechanics.

[137]  L. White,et al.  Lateral separation of colloids or cells by dielectrophoresis augmented by AC electroosmosis. , 2005, Journal of colloid and interface science.

[138]  P. Gascoyne,et al.  Particle separation by dielectrophoresis , 2002, Electrophoresis.

[139]  N. Abbott,et al.  Using Light to Control Dynamic Surface Tensions of Aqueous Solutions of Water Soluble Surfactants , 1999 .

[140]  Cengiz S. Ozkan,et al.  Electric Field Assisted Patterning of Neuronal Networks for the Study of Brain Functions , 2003 .

[141]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[142]  M. Bohmer In Situ Observation of 2-Dimensional Clustering during Electrophoretic Deposition , 1996 .

[143]  Ajdari,et al.  Electro-osmosis on inhomogeneously charged surfaces. , 1995, Physical review letters.

[144]  D. Saville,et al.  Assembly of colloidal aggregates by electrohydrodynamic flow: Kinetic experiments and scaling analysis. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[145]  Andrew G. Glen,et al.  APPL , 2001 .

[146]  J. Jacobson,et al.  An electrophoretic ink for all-printed reflective electronic displays , 1998, Nature.

[147]  H. A. Pohl The Motion and Precipitation of Suspensoids in Divergent Electric Fields , 1951 .

[148]  Michael Seul,et al.  Assembly of ordered colloidal aggregrates by electric-field-induced fluid flow , 1997, Nature.

[149]  Qiang Zhao,et al.  Electrochemical sensors based on carbon nanotubes , 2002 .

[150]  D A Saville,et al.  Electrically guided assembly of planar superlattices in binary colloidal suspensions. , 2003, Physical review letters.

[151]  L. Yeo,et al.  Electrowetting films on parallel line electrodes. , 2006, Physical review. E, Statistical, nonlinear, and soft matter physics.

[152]  Lee R. White,et al.  Electrophoretic mobility of a spherical colloidal particle in an oscillating electric field , 1992 .

[153]  Carl D. Meinhart,et al.  Experimental analysis of particle and fluid motion in ac electrokinetics , 2005 .

[154]  M. Heller,et al.  Dielectrophoretic cell separation and gene expression profiling on microelectronic chip arrays. , 2002, Analytical chemistry.

[155]  O. Velev,et al.  On-chip manipulation of free droplets , 2003, Nature.

[156]  Hywel Morgan,et al.  AC ELECTROKINETICS: COLLOIDS AND NANOPARTICLES. , 2002 .

[157]  Zachary Gagnon,et al.  Aligning fast alternating current electroosmotic flow fields and characteristic frequencies with dielectrophoretic traps to achieve rapid bacteria detection , 2005, Electrophoresis.

[158]  J. Lyklema Water at interfaces: A colloid-chemical approach , 1977 .

[159]  D. A. Saville,et al.  Electrophoretic assembly of colloidal crystals with optically tunable micropatterns , 2000, Nature.

[160]  M. Chaudhury,et al.  Rectified Motion of Liquid Drops on Gradient Surfaces Induced by Vibration , 2002 .

[161]  Hari Singh Nalwa,et al.  Handbook of surfaces and interfaces of materials , 2001 .

[162]  Shah,et al.  Electrochemical principles for active control of liquids on submillimeter scales , 1999, Science.

[163]  Nicholas A. Kotov,et al.  Electrophoretic Deposition of Latex-Based 3D Colloidal Photonic Crystals: A Technique for Rapid Production of High-Quality Opals , 2000 .

[164]  Hsueh-Chia Chang,et al.  PROOF COPY 022212PHF Nonlinear electrokinetic ejection and entrainment due to polarization at nearly insulated wedges , 2002 .

[165]  Hsueh-Chia Chang,et al.  Particle detection by electrical impedance spectroscopy with asymmetric-polarization AC electroosmotic trapping , 2005 .

[166]  W. Balachandran,et al.  Sub-micron sized biological particle manipulation and characterisation , 2001 .

[167]  Giovanni De Gasperis,et al.  Trapping of micrometre and sub-micrometre particles by high-frequency electric fields and hydrodynamic forces , 1996 .

[168]  H. Morgan,et al.  Ac electrokinetics: a review of forces in microelectrode structures , 1998 .

[169]  E. Dulkeith,et al.  Lateral Patterning of CdTe Nanocrystal Films by the Electric Field Directed Layer-by-Layer Assembly Method , 2002 .