Condensational growth of combination drug‐excipient submicrometer particles for targeted high‐efficiency pulmonary delivery: evaluation of formulation and delivery device

Objectives  The objective of this study was to investigate the in‐vitro particle‐size growth of combination drug and excipient submicrometer aerosols generated from a series of formulations and two aerosol delivery devices.

[1]  M. Hindle,et al.  Evaluation of the Respimat Soft Mist Inhaler using a concurrent CFD and in vitro approach. , 2009, Journal of aerosol medicine and pulmonary drug delivery.

[2]  B. Zierenberg Optimizing the in vitro performance of Respimat. , 1999, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[3]  C. Kim,et al.  Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women. , 2000, Inhalation toxicology.

[4]  J. Thudium Water uptake and equilibrium sizes of aerosol particles at high relative humidities: Their dependence on the composition of the water-soluble material , 1978 .

[5]  T. Voshaar,et al.  A review of the development of Respimat Soft Mist Inhaler. , 2004, International journal of pharmaceutics.

[6]  Gottfried Hänel,et al.  Aerosol size and relative humidity: Water uptake by mixtures of salts , 1979 .

[7]  P Worth Longest,et al.  Characterization of Nanoaerosol Size Change During Enhanced Condensational Growth , 2010, Aerosol science and technology : the journal of the American Association for Aerosol Research.

[8]  P. Worth Longest,et al.  Condensational Growth of Combination Drug-Excipient Submicrometer Particles for Targeted High Efficiency Pulmonary Delivery: Comparison of CFD Predictions with Experimental Results , 2011, Pharmaceutical Research.

[9]  Bo Olsson,et al.  Degree of throat deposition can explain the variability in lung deposition of inhaled drugs. , 2006, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[10]  M. Hindle,et al.  Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data , 2007 .

[11]  Jinxiang Xi,et al.  Transport and Deposition of Micro-Aerosols in Realistic and Simplified Models of the Oral Airway , 2007, Annals of Biomedical Engineering.

[12]  M. Hindle,et al.  Evaluation of Enhanced Condensational Growth (ECG) for Controlled Respiratory Drug Delivery in a Mouth-Throat and Upper Tracheobronchial Model , 2010, Pharmaceutical Research.

[13]  Yu Zhang,et al.  In vivo-in vitro comparison of deposition in three mouth-throat models with Qvar and Turbuhaler inhalers. , 2007, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[14]  P Worth Longest,et al.  CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data. , 2010, Journal of aerosol science.

[15]  T. Martonen,et al.  Behavior of Hygroscopic Pharmaceutical Aerosols and the Influence of Hydrophobic Additives , 2004, Pharmaceutical Research.

[16]  I. Gonda,et al.  Perspectives on the Biopharmacy of Inhalation Aerosols , 1978 .

[17]  Michael Hindle,et al.  Numerical Model to Characterize the Size Increase of Combination Drug and Hygroscopic Excipient Nanoparticle Aerosols , 2011, Aerosol science and technology : the journal of the American Association for Aerosol Research.

[18]  E. Israel,et al.  Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network. , 1996, American journal of respiratory and critical care medicine.

[19]  C. Leach,et al.  Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. , 1998, The European respiratory journal.

[20]  W. J. Irwin,et al.  Effect of hydrophobic coating on the behavior of a hygroscopic aerosol powder in an environment of controlled temperature and relative humidity. , 1990, Journal of pharmaceutical sciences.

[21]  Geng Tian,et al.  Characterization of Respiratory Drug Delivery with Enhanced Condensational Growth using an Individual Path Model of the Entire Tracheobronchial Airways , 2011, Annals of Biomedical Engineering.

[22]  Y. Cheng,et al.  Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica. , 2001, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[23]  W. Busse,et al.  Evolution of dry powder inhaler design, formulation, and performance. , 2002, Respiratory medicine.