Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia.

In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.

[1]  M. Relling,et al.  Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. , 2005, Cancer cell.

[2]  R. Griffin,et al.  Preferential action of arsenic trioxide in solid-tumor microenvironment enhances radiation therapy. , 2005, International journal of radiation oncology, biology, physics.

[3]  Cheng Cheng,et al.  Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. , 2004, The New England journal of medicine.

[4]  J. Karlsson,et al.  Arsenic Trioxide-Induced Death of Neuroblastoma Cells Involves Activation of Bax and Does Not Require p53 , 2004, Clinical Cancer Research.

[5]  M. D. Boer,et al.  Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  W. Tissing,et al.  Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform‐specific real‐time polymerase chain reaction approach , 2003, British journal of haematology.

[7]  S. Armstrong,et al.  Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. , 2003, Blood.

[8]  M. Schrappe,et al.  Clinical Outcome of Patients with Childhood Acute Lymphoblastic Leukaemia and an Initial Leukaemic Blood Blast Count of Less than 1000 per Microliter , 2001, Klinische Padiatrie.

[9]  R. Latagliata,et al.  Arsenic trioxide in the treatment of advanced acute promyelocytic leukemia. , 2004, Haematologica.

[10]  M. Schrappe,et al.  Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia. , 2003, Haematologica.

[11]  W. Tissing,et al.  Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia , 2003, Leukemia.