cysteine proteinases including osteoclastic cathepsin K Pathologic gene expression in Gaucher disease: up-regulation of

[1]  M. Duffy The role of proteolytic enzymes in cancer invasion and metastasis , 1992, Clinical & Experimental Metastasis.

[2]  K. Matsushima,et al.  Serial analysis of gene expression in human monocytes and macrophages. , 1999, Blood.

[3]  G. Dranoff,et al.  Cathepsin S required for normal MHC class II peptide loading and germinal center development. , 1999, Immunity.

[4]  A. Rudensky,et al.  Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. , 1999, Immunity.

[5]  Sheila J. Jones,et al.  Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[6]  P. Libby,et al.  Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. , 1998, The Journal of clinical investigation.

[7]  R. Mitchell,et al.  Cathepsin S activity regulates antigen presentation and immunity. , 1998, The Journal of clinical investigation.

[8]  K. Kanaoka,et al.  Fluorescence microscopic demonstration of cathepsin K activity as the major lysosomal cysteine proteinase in osteoclasts. , 1998, Journal of biochemistry.

[9]  Y. Okamura-Oho,et al.  Maturation and degradation of β‐galactosidase in the post‐Golgi compartment are regulated by cathepsin B and a non‐cysteine protease , 1997, FEBS letters.

[10]  T. Cox,et al.  3 Gaucher's disease: clinical features and natural history , 1997 .

[11]  C. Hollak,et al.  4 Plasma and metabolic abnormalities in Gaucher's disease , 1997 .

[12]  M. Horowitz,et al.  Gaucher's disease: molecular, genetic and enzymological aspects. , 1997, Bailliere's clinical haematology.

[13]  Y. Sakaki,et al.  A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. , 1997, Journal of immunology.

[14]  C. Debouck,et al.  Genomic organization and chromosome localization of the human cathepsin K gene (CTSK). , 1997, Genomics.

[15]  L. Schaefer,et al.  Specific Catalytic Activity of Cathepsin S in Comparison to Cathepsins B and L along the Rat Nephron , 1997, Biological chemistry.

[16]  Xiayang Qiu,et al.  Crystal structure of human osteoclast cathepsin K complex with E-64 , 1997, Nature Structural Biology.

[17]  N. Rushton,et al.  Pro-inflammatory cytokines and the pathogenesis of Gaucher's disease: increased release of interleukin-6 and interleukin-10. , 1997, QJM : monthly journal of the Association of Physicians.

[18]  C. Hollak,et al.  Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease. , 1996, Biochimica et biophysica acta.

[19]  B. Gelb,et al.  Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency , 1996, Science.

[20]  Aaron P. Campbell,et al.  Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[21]  D. Mcnulty,et al.  Proteolytic Activity of Human Osteoclast Cathepsin K , 1996, The Journal of Biological Chemistry.

[22]  C. Debouck,et al.  Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (*) , 1996, The Journal of Biological Chemistry.

[23]  D. Breuillé,et al.  Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways. , 1996, The Journal of clinical investigation.

[24]  D. Brömme,et al.  Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts , 1996, The Journal of Biological Chemistry.

[25]  M. Yano,et al.  Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. , 1996, The Journal of clinical investigation.

[26]  A. V. van Zonneveld,et al.  Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages (*) , 1995, The Journal of Biological Chemistry.

[27]  D. Brömme,et al.  Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution. , 1995, Biological chemistry Hoppe-Seyler.

[28]  A. Baici,et al.  Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage. , 1995, Annals of the rheumatic diseases.

[29]  G. Bilbe,et al.  Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone. , 1995, Biochemical and biophysical research communications.

[30]  N. Ajubi,et al.  nmb, a novel gene, is expressed in low‐metastatic human melanoma cell lines and xenografts , 1995, International journal of cancer.

[31]  S. Ho,et al.  A surrogate 15 kDa JC kappa protein is expressed in combination with mu heavy chain by human B cell precursors. , 1994, The EMBO journal.

[32]  Jessup Jm Cathepsin B and other proteases in human colorectal carcinoma. , 1994 .

[33]  A. C. Webb,et al.  Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. , 1994, The Journal of biological chemistry.

[34]  J. Chirgwin,et al.  Cloning and characterization of the 5′‐flanking region of the mouse tartrate‐resistant acid phosphatase gene , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[35]  T. Chambers,et al.  Degradation of bone matrix proteins by osteoclast cathepsins. , 1993, The International journal of biochemistry.

[36]  L. Devi,et al.  Sequence analysis, tissue distribution, and expression of rat cathepsin S. , 1992, The Journal of biological chemistry.

[37]  A. Saven,et al.  Gaucher Disease: Clinical, Laboratory, Radiologic, and Genetic Features of 53 Patients , 1992, Medicine.

[38]  S. Takao,et al.  A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression. , 1992, Journal of biochemistry.

[39]  C. R. Connell,et al.  DNA sequencing with dye-labeled terminators and T7 DNA polymerase: effect of dyes and dNTPs on incorporation of dye-terminators and probability analysis of termination fragments. , 1992, Nucleic acids research.

[40]  D. Rich,et al.  Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. , 1992, The Journal of biological chemistry.

[41]  T. Chambers,et al.  Human osteoclastomas contain multiple forms of cathepsin B. , 1992, Biochimica et biophysica acta.

[42]  R. Gay,et al.  Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis. , 2010, Arthritis and rheumatism.

[43]  A. D. Dunn,et al.  Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L. , 1991, The Journal of biological chemistry.

[44]  W. Hsueh,et al.  Identification of renal cathepsin B as a human prorenin-processing enzyme. , 1991, The Journal of biological chemistry.

[45]  D. Sheer,et al.  Type 5 acid phosphatase. Sequence, expression and chromosomal localization of a differentiation-associated protein of the human macrophage. , 1990, European journal of biochemistry.

[46]  H. Kirschke,et al.  Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins. , 1989, The Biochemical journal.

[47]  D. Steiner,et al.  Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues. , 1989, Cancer research.

[48]  P. Marynen,et al.  Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts. , 1989, The Journal of biological chemistry.

[49]  Bonnie F. Sloane,et al.  Enhanced levels of cathepsin B mRNA in murine tumors , 1989, FEBS letters.

[50]  R. Maciewicz,et al.  A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen. , 1988, The Biochemical journal.

[51]  K. Svenson,et al.  The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. , 1987, The Journal of biological chemistry.

[52]  D. Steiner,et al.  Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[53]  J. Tang,et al.  Porcine spleen cathepsin B is an exopeptidase. , 1986, The Journal of biological chemistry.

[54]  D. Steiner,et al.  Differences in cathepsin B mRNA levels in rat tissues ssuggest specialized functions , 1986, FEBS letters.

[55]  A. Feinberg,et al.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. , 1983, Analytical biochemistry.

[56]  K. Suzuki Glucosylceramide and related compounds in normal tissues and in Gaucher disease. , 1982, Progress in clinical and biological research.

[57]  R. Brady,et al.  Selective effects of glucocerebroside (Gaucher's storage material) on macrophage cultures. , 1981, The Journal of clinical investigation.

[58]  A. Barrett Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates. , 1980, The Biochemical journal.

[59]  H. Towbin,et al.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[60]  A. Barrett,et al.  The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism. , 1978, The Biochemical journal.

[61]  C. R. Barker,et al.  Surface marker and other characteristics of Gaucher's cells. , 1977, Journal of clinical pathology.

[62]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[63]  R. Brady,et al.  METABOLISM OF GLUCOCEREBROSIDES. II. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN GAUCHER'S DISEASE. , 1965, Biochemical and biophysical research communications.