Applications of biomolecular interaction analysis in drug development

Abstract Biomolecular interaction analysis (BIA) is now utilised increasingly in drug development to kinetically characterise binding events of relevant components. BIA thereby covers a broad range of applications in early ADME (adsorption, distribution, metabolism and excretion), secondary screens, functional and metabolic assays and in assay development. This versatile technology allows measurements in real time without the need of labelling. A wide range of affinities can be characterised in a near-native state, with high reproducibility, high sensitivity and low sample consumption. However, limitations due to experimental design, and limitations in sample throughput, may occur. Future developments of BIA aim at parallelisation and automatisation and at coupling to platform technologies already established in the drug development process.

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