Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2

CPVT-linked RYR2 mutations are prone to induce spontaneous Ca2+ release from the ER, which is associated with arrhythmias. Kurebayashi et al. used experiments and simulations to explore the mechanisms relating cytosolic Ca2+-dependent activity by RYR2 mutations and spontaneous Ca2+ release.

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