Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children

BackgroundPrevious investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to examine the relationships between bitter tasting ability and variation at the TAS2R38 locus and to assess the role of psychosocial factors in explaining residual, within group, variation in tasting ability.ResultsIn a large sample of children from the Avon Longitudinal Study of Parents and Children, we confirmed an association between bitter compound tasting ability and TAS2R38 variation and found evidence of a genetic association with intermediate tasting ability. Antisocial behaviour, social class and depression showed no consistent relationship with the distribution of taste test scores.ConclusionFactors which could influence a child's chosen taste score, extra to taste receptor variation, appeared not to show relationships with test score. Observed spread in the distribution of the taste test scores within hypothesised taster groups, is likely to be, or at least in part, due to physiological differentiation regulated by other genetic contributors. Results confirm relationships between genetic variation and bitter compound tasting ability in a large sample, and suggest that TAS2R38 variation may also be associated with intermediate tasting ability.

[1]  K. Kidd,et al.  Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. , 2004, Alcoholism, clinical and experimental research.

[2]  M. W. Klein,et al.  Cross-National Research in Self-Reported Crime and Delinquency , 1989 .

[3]  Tom R. Gaunt,et al.  TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. , 2005, The American journal of clinical nutrition.

[4]  E. Thompson,et al.  Performing the exact test of Hardy-Weinberg proportion for multiple alleles. , 1992, Biometrics.

[5]  J. Weiffenbach,et al.  Association Between 6-n-Propylthiouracil (PROP) Bitterness and Colonic Neoplasms , 2005, Digestive Diseases and Sciences.

[6]  I. J. Miller.  Variation in human fungiform taste bud densities among regions and subjects , 1986, The Anatomical record.

[7]  Mark Leppert,et al.  Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide , 2003, Science.

[8]  I. J. Miller,et al.  Variation in Human Taste Bud Density as a Function of Age a , 1989, Annals of the New York Academy of Sciences.

[9]  S. Ring,et al.  A new human genetic resource: a DNA bank established as part of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC) , 2000, European Journal of Human Genetics.

[10]  J. Slack,et al.  The Molecular Basis of Individual Differences in Phenylthiocarbamide and Propylthiouracil Bitterness Perception , 2005, Current Biology.

[11]  B. Tepper.  6-n-Propylthiouracil: a genetic marker for taste, with implications for food preference and dietary habits. , 1998, American journal of human genetics.

[12]  M. Behrens,et al.  Signaling in the Chemosensory Systems , 2006, Cellular and Molecular Life Sciences CMLS.

[13]  Linda M. Bartoshuk,et al.  PTC/PROP tasting: Anatomy, psychophysics, and sex effects , 1994, Physiology & Behavior.

[14]  P. Breslin,et al.  Relationship of papillae number to bitter intensity of quinine and PROP within and between individuals , 2001, Physiology & Behavior.

[15]  A. Blakeslee,et al.  OUR DIFFERENT TASTE WORLDS P. T. C. as a Demonstration of Genetic Differences in Taste , 1932 .

[16]  M. Pembrey,et al.  ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology. , 2001, Paediatric and perinatal epidemiology.

[17]  C. Bell,et al.  Localization of a gene for bitter-taste perception to human chromosome 5p15. , 1999, American journal of human genetics.

[18]  Adrian Angold,et al.  Development of a Short Questionnaire for Use in Epidemiological Studies of Depression in Children and Adolescents: Factor Composition and Structure Across Development. , 1995 .

[19]  David P. Farrington,et al.  Development of a New Measure of Self-Reported Antisocial Behavior for Young Children: Prevalence and Reliability , 1989 .

[20]  D. Reed,et al.  The genetics of phenylthiocarbamide perception. , 2001, Annals of human biology.

[21]  Linda M. Bartoshuk,et al.  Differences in Our Sensory Worlds , 2005 .

[22]  Surveys.,et al.  Standard occupational classification , 1990 .

[23]  M. Boehnke,et al.  Alternative genetic models for the inheritance of the phenylthiocarbamide taste deficiency , 1989, Genetic epidemiology.

[24]  H. Coon,et al.  Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p , 2003, Human Genetics.

[25]  I. J. Miller,et al.  Variations in human taste bud density and taste intensity perception , 1990, Physiology & Behavior.

[26]  A. L. Fox.  The Relationship between Chemical Constitution and Taste. , 1932, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Peter Donnelly,et al.  A comparison of bayesian methods for haplotype reconstruction from population genotype data. , 2003, American journal of human genetics.

[28]  H. Kalmus,et al.  Taste thresholds of further eighteen compounds and their correlation with P.T.C thresholds. , 1951, Annals of eugenics.

[29]  V. Duffy,et al.  Food acceptance and genetic variation in taste. , 2000, Journal of the American Dietetic Association.

[30]  H. Kalmus,et al.  Chemical specificity in genetical differences of taste sensitivity. , 1949, Annals of eugenics.

[31]  W. Nance,et al.  Linkage relations of the loci for Kell and phenylthiocarbamide taste sensitivity. , 1976, Human heredity.

[32]  D. Rao,et al.  Phenylthiocarbamide taste sensitivity revisited: Complete sorting test supports residual family resemblance , 1989, Genetic epidemiology.