Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.
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A. Ghose | Brian T. Campbell | Raffaella Faraoni | Darren E. Insko | Andiliy G. Lai | E. Setti | R. Armstrong | B. Ruggeri | T. Herbertz | R. Gunawardane | Merryl D. Cramer | Q. Chao | K. Sprankle | J. James | S. Bhagwat | Sunny Abraham | B. Dorsey | R. Nepomuceno | M. Holladay | M. Ator | J. Apuy | Michael Williams | S. Jones-Bolin | Maiko Ezawa | L. Tran | M. Gibney | M. Gardner | M. Rowbottom | Helen Hua | Dana Gitnick | Brian Struss | Ianina Valenta | Michael J. Gibney