Discovery of novel and selective SIRT6 inhibitors.
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C. Franceschi | A. Ballestrero | P. Damonte | S. Bruzzone | A. Nencioni | M. Parenti | A. Del Rio | E. Millo | Giovanna Sociali | Alessia Grozio | Lauretta Galeno | I. Bauer | G. Sociali | Inga Bauer
[1] R. Mostoslavsky,et al. The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease. , 2013, Current topics in medicinal chemistry.
[2] S. Bruzzone,et al. Editorial (Thematic Issue: NAD + Biosynthesis and Signaling as an Emerging Area in Medicinal Chemistry) , 2013 .
[3] Tian Zhu,et al. Hit identification and optimization in virtual screening: practical recommendations based on a critical literature analysis. , 2013, Journal of medicinal chemistry.
[4] Yi Wang,et al. Sirt6 regulates TNFα secretion via hydrolysis of long chain fatty acyl lysine , 2013, Nature.
[5] Alberto Del Rio,et al. Modulation of Epigenetic Targets for Anticancer Therapy: Clinicopathological Relevance, Structural Data and Drug Discovery Perspectives , 2012, Current pharmaceutical design.
[6] A. Ballestrero,et al. Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets , 2012, Current pharmaceutical design.
[7] A. Regev,et al. The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism , 2012, Cell.
[8] G. Feldmann,et al. The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+ Responses* , 2012, The Journal of Biological Chemistry.
[9] J. Denu,et al. Sirtuin Catalysis and Regulation* , 2012, The Journal of Biological Chemistry.
[10] F. Jiang,et al. Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5. , 2012, The Journal of organic chemistry.
[11] Alberto Del Rio,et al. Freely accessible databases of commercial compounds for high- throughput virtual screenings. , 2012 .
[12] S. Singhal,et al. Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging , 2012, Molecular and Cellular Biochemistry.
[13] Pierre Tufféry,et al. The FAF-Drugs2 server: a multistep engine to prepare electronic chemical compound collections , 2011, Bioinform..
[14] A. Seluanov,et al. SIRT6 Promotes DNA Repair Under Stress by Activating PARP1 , 2011, Science.
[15] W. Sippl,et al. Computer- and structure-based lead design for epigenetic targets. , 2011, Bioorganic & medicinal chemistry.
[16] P. Pan,et al. Structure and Biochemical Functions of SIRT6* , 2011, The Journal of Biological Chemistry.
[17] Giuseppe Felice Mangiatordi,et al. CoCoCo: a free suite of multiconformational chemical databases for high-throughput virtual screening purposes. , 2010, Molecular bioSystems.
[18] Oksana Gavrilova,et al. SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice* , 2010, The Journal of Biological Chemistry.
[19] J. Baell,et al. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. , 2010, Journal of medicinal chemistry.
[20] Orian S. Shirihai,et al. The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α , 2010, Cell.
[21] A. Ballestrero,et al. Catastrophic NAD+ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE , 2009, PloS one.
[22] C. Deng,et al. Recent progress in the biology and physiology of sirtuins , 2009, Nature.
[23] Véronique Kruys,et al. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner , 2009, Nature Medicine.
[24] Howard Y. Chang,et al. SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span , 2009, Cell.
[25] Olivier Sperandio,et al. FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects , 2008, BMC Bioinformatics.
[26] Howard Y. Chang,et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin , 2008, Nature.
[27] Pingfang Liu,et al. Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 , 2006, Cell.
[28] C. Wolberger,et al. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. , 2005, Molecular cell.
[29] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .
[30] Santosh A. Khedkar,et al. Successful applications of computer aided drug discovery: moving drugs from concept to the clinic. , 2010, Current topics in medicinal chemistry.