Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model
暂无分享,去创建一个
[1] Caroline F. Wright,et al. De novo mutations in regulatory elements in neurodevelopmental disorders , 2018, Nature.
[2] Sina A. Gharib,et al. Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood , 2018, Nature Communications.
[3] Jakob Grove,et al. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection , 2018, Nature Genetics.
[4] Cook,et al. Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps , 2018, bioRxiv.
[5] Martin C Frith,et al. A survey of localized sequence rearrangements in human DNA , 2017, Nucleic acids research.
[6] Jean-Claude Tardif,et al. HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology , 2018, Nature Reviews Cardiology.
[7] K. Brennand,et al. Mapping regulatory variants in hiPSC models , 2017, Nature Genetics.
[8] Brent S. Pedersen,et al. A map of constrained coding regions in the human genome , 2017, Nature Genetics.
[9] S. Faraone. The Omnigenic Model: Implications for Psychiatric Genetics , 2017 .
[10] Nancy J. Cox. Comments on Pritchard Paper , 2017 .
[11] Yang I Li,et al. The Omnigenic Model: Response from the Authors , 2017 .
[12] B. Franke. What’s in a Name: the “Omnigenic” Model as a Point of Departure for Polygenic Psychiatric Disorders , 2017 .
[13] Yufeng Shen,et al. Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands , 2017, Nature Genetics.
[14] Enrico Amico,et al. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. , 2017, The Lancet. Neurology.
[15] Timothy Caulfield,et al. Genes, cells, and biobanks: Yes, there’s still a consent problem , 2017, PLoS biology.
[16] Yang I Li,et al. An Expanded View of Complex Traits: From Polygenic to Omnigenic , 2017, Cell.
[17] M. Daly,et al. Regional missense constraint improves variant deleteriousness prediction , 2017, bioRxiv.
[18] Marius Wernig,et al. μNeurocircuitry: Establishing in vitro models of neurocircuits with human neurons. , 2017, Technology.
[19] E. Callaway. New concerns raised over value of genome-wide disease studies , 2017, Nature.
[20] Alireza Mashaghi,et al. An end-user perspective on Organ-on-a-Chip : Assays and usability aspects , 2017 .
[21] Christine A. Sedore,et al. Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects , 2017, Nature Communications.
[22] M. Berger,et al. Precision oncology: Charting a path forward to broader deployment of genomic profiling , 2017, PLoS medicine.
[23] N. Baliga,et al. The State of Systems Genetics in 2017. , 2017, Cell systems.
[24] Deciphering Developmental Disorders Study,et al. Prevalence and architecture of de novo mutations in developmental disorders , 2017, Nature.
[25] Daniel J. Gaffney,et al. Molecular and functional variation in iPSC-derived sensory neurons , 2017, bioRxiv.
[26] Marcelo P. Segura-Lepe,et al. Rare and low-frequency coding variants alter human adult height , 2016, Nature.
[27] A. Price,et al. Dissecting the genetics of complex traits using summary association statistics , 2016, Nature Reviews Genetics.
[28] Loukas Moutsianas,et al. Exploring the genetic architecture of inflammatory bowel disease , 2016 .
[29] Jos Joore,et al. High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform , 2016, Scientific Reports.
[30] Hyejung Won,et al. The road to precision psychiatry: translating genetics into disease mechanisms , 2016, Nature Neuroscience.
[31] Giulio Genovese,et al. Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia , 2016, Nature Neuroscience.
[32] Stephen C. J. Parker,et al. The genetic architecture of type 2 diabetes , 2016, Nature.
[33] A. Chakravarti,et al. Revealing rate‐limiting steps in complex disease biology: The crucial importance of studying rare, extreme‐phenotype families , 2016, BioEssays : news and reviews in molecular, cellular and developmental biology.
[34] The effect of gene interactions on the long-term response to selection , 2016, Proceedings of the National Academy of Sciences.
[35] M. Keshavan,et al. Biomarkers in Psychiatry - A Critique , 2016, Annals of Neurosciences.
[36] Giulio Genovese,et al. Schizophrenia risk from complex variation of complement component 4 , 2016, Nature.
[37] Martin Eklund,et al. Prostate cancer screening in men aged 50-69 years (STHLM3): a prospective population-based diagnostic study. , 2015, The Lancet. Oncology.
[38] B. Shields,et al. A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults , 2015, Diabetes Care.
[39] Genetic differential calculus , 2015, Nature Genetics.
[40] P. Visscher,et al. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index , 2015, Nature Genetics.
[41] Jane S. Paulsen,et al. Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease , 2015, Cell.
[42] Daniel H. Geschwind,et al. Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders , 2015, Nature Reviews Genetics.
[43] P. Visscher,et al. Nature Genetics Advance Online Publication , 2022 .
[44] Mulin Jun Li,et al. Nature Genetics Advance Online Publication a N a Ly S I S the Support of Human Genetic Evidence for Approved Drug Indications , 2022 .
[45] W. G. Hill,et al. Dominance genetic variation contributes little to the missing heritability for human complex traits. , 2015, American journal of human genetics.
[46] P. Elliott,et al. UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.
[47] F. Collins,et al. A new initiative on precision medicine. , 2015, The New England journal of medicine.
[48] Naomi R. Wray,et al. Genetic Studies of Major Depressive Disorder: Why Are There No Genome-wide Association Study Findings and What Can We Do About It? , 2014, Biological Psychiatry.
[49] C. Spencer,et al. Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.
[50] W. G. Hill,et al. Influence of Gene Interaction on Complex Trait Variation with Multilocus Models , 2014, Genetics.
[51] Samuel F. Berkovic,et al. The hidden genetics of epilepsy—a clinically important new paradigm , 2014, Nature Reviews Neurology.
[52] A. Lusis,et al. Systems genetics approaches to understand complex traits , 2013, Nature Reviews Genetics.
[53] M. McGilliard,et al. Phenotypic responses of chickens to long-term, bidirectional selection for juvenile body weight--historical perspective. , 2013, Poultry science.
[54] Patrick F. Sullivan,et al. Genetic architectures of psychiatric disorders: the emerging picture and its implications , 2012, Nature Reviews Genetics.
[55] Adam Kiezun,et al. Exome sequencing and the genetic basis of complex traits , 2012, Nature Genetics.
[56] P. Visscher,et al. Genetic architecture of body size in mammals , 2012, Genome Biology.
[57] Joseph K. Pickrell,et al. A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes , 2012, Science.
[58] E. Lander,et al. The mystery of missing heritability: Genetic interactions create phantom heritability , 2012, Proceedings of the National Academy of Sciences.
[59] M C O'Donovan,et al. Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia , 2011, Molecular Psychiatry.
[60] S. Salzberg,et al. Repetitive DNA and next-generation sequencing: computational challenges and solutions , 2011, Nature Reviews Genetics.
[61] F. Agakov,et al. Abundant pleiotropy in human complex diseases and traits. , 2011, American journal of human genetics.
[62] David M. Simcha,et al. Tackling the widespread and critical impact of batch effects in high-throughput data , 2010, Nature Reviews Genetics.
[63] Marylyn D. Ritchie,et al. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations , 2010, Bioinform..
[64] W. G. Hill,et al. Understanding and using quantitative genetic variation , 2010, Philosophical Transactions of the Royal Society B: Biological Sciences.
[65] A. Barabasi,et al. Network medicine : a network-based approach to human disease , 2010 .
[66] M. Siegal,et al. Robustness: mechanisms and consequences. , 2009, Trends in genetics : TIG.
[67] P. Visscher,et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder , 2009, Nature.
[68] P. Phillips. Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems , 2008, Nature Reviews Genetics.
[69] David L Stern,et al. The Loci of Evolution: How Predictable is Genetic Evolution? , 2008, Evolution; international journal of organic evolution.
[70] M. Slatkin. Exchangeable Models of Complex Inherited Diseases , 2008, Genetics.
[71] W. G. Hill,et al. Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits , 2008, PLoS genetics.
[72] Joachim Hermisson,et al. EVOLUTION OF GENETIC ARCHITECTURE UNDER DIRECTIONAL SELECTION , 2006, Evolution; international journal of organic evolution.
[73] Stylianos E. Antonarakis,et al. Mendelian disorders deserve more attention , 2006, Nature Reviews Genetics.
[74] J. Pritchard,et al. The allelic architecture of human disease genes: common disease-common variant...or not? , 2002, Human molecular genetics.
[75] E. Lander,et al. On the allelic spectrum of human disease. , 2001, Trends in genetics : TIG.
[76] J. Pritchard. Are rare variants responsible for susceptibility to complex diseases? , 2001, American journal of human genetics.
[77] J. Cheverud. Genetics and analysis of quantitative traits , 1999 .
[78] M. Lynch,et al. Genetics and Analysis of Quantitative Traits , 1996 .
[79] H. A. Orr,et al. The Genetics of Adaptation: A Reassessment , 1992, The American Naturalist.
[80] M. Kimura,et al. An introduction to population genetics theory , 1971 .
[81] J. Shields,et al. A polygenic theory of schizophrenia , 1967 .
[82] L. Penrose. The genetical background of common diseases. , 1953, Acta genetica et statistica medica.