Tomographic Imaging of BiologicalTissue by Time-Resolved, Model-Based, Iterative Image Reconstruction

Currently available tomographic image reconstruction schemes for photon migration tomography (PMT) are mostly based on the limiting assumptions of small perturbations and a priori knowledge of the optical properties of a reference medium. In this work a modelbased iterative image reconstruction (MOBIIR) method is presented, which does not require the knowledge of a reference medium or that the encountered heterogeneities are small perturbations. After a description of the major code structure and a review of the mathematical background, the clinically relevant examples of brain imaging and breast cancer detection and are discussed. It is shown that ventricular bleedings in the brain can be detected and that cysts and tumors in the breast can be distinguished using the MOBIIR technique.

[1]  Hanli Liu,et al.  Characterization of absorption and scattering properties of small-volume biological samples using time-resolved spectroscopy. , 1993, Analytical biochemistry.

[2]  E. Gratton,et al.  Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry , 1995 .

[3]  R G Grossman,et al.  Early detection of delayed traumatic intracranial hematomas using near-infrared spectroscopy. , 1995, Journal of neurosurgery.

[4]  R. Barbour,et al.  Frequency-domain optical imaging of absorption and scattering distributions by a Born iterative method. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[5]  B. Pogue,et al.  Optical image reconstruction using frequency-domain data: simulations and experiments , 1996 .

[6]  David Friedman,et al.  Rapid Changes of Optical Parameters in the Human Brain During a Tapping Task , 1995, Journal of Cognitive Neuroscience.

[7]  Britton Chance,et al.  Optical Tomography and Spectroscopy of Tissue VIII , 1999 .

[8]  Harry L. Graber,et al.  MRI-guided optical tomography: prospects and computation for a new imaging method , 1995 .

[9]  Britton Chance,et al.  Development of time-resolved spectroscopy system for quantitative noninvasive tissue measurement , 1995, Photonics West.

[10]  Britton Chance,et al.  Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II , 1997 .

[11]  Kevin Wells,et al.  UCL multichannel time-resolved system for optical tomography , 1997, Photonics West - Biomedical Optics.

[12]  J. Melissen,et al.  Tomographic image reconstruction from optical projections in light-diffusing media. , 1997, Applied optics.

[13]  Britton Chance,et al.  Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation , 1995 .

[14]  B. Chance,et al.  Spectroscopy and Imaging with Diffusing Light , 1995 .

[15]  Kenneth M. Hanson,et al.  Model-based image reconstruction from time-resolved diffusion data , 1997, Medical Imaging.

[16]  D. Boas,et al.  Experimental images of heterogeneous turbid media by frequency-domain diffusing-photon tomography. , 1995, Optics letters.

[17]  Judith R. Mourant,et al.  Physiological monitoring of brain function with a broadband multifiber continuous-wave optical system , 1997, Photonics West - Biomedical Optics.

[18]  James G. Fujimoto,et al.  Advances in Optical Imaging and Photon Migration , 1996 .

[19]  E. Gratton,et al.  Image reconstruction by backprojection from frequency-domain optical measurements in highly scattering media. , 1997, Applied optics.

[20]  D. Benaron,et al.  Imaging Brain Injury Using Time-Resolved Near Infrared Light Scanning , 1996, Pediatric Research.

[21]  D. O'connor,et al.  Time-Correlated Single Photon Counting , 1984 .