Single spin‐echo proton transverse relaxometry of iron‐loaded liver

A single‐spin‐echo methodology is described for the measurement and imaging of proton transverse relaxation rates (R2) in iron‐loaded and normal human liver tissue in vivo. The methodology brings together previously reported techniques dealing with (i) the changes in gain between each spin‐echo acquisition, (ii) signal level offset due to background noise, (iii) estimation of signal intensities in decay curves at time zero to enable reliable extraction of relaxation times from tissues with very short T2 values, (iv) bi‐exponential modelling of decay curves with a small number of data points, and (v) reduction of respiratory motion artefacts. The accuracy of the technique is tested on aqueous manganese chloride solutions yielding a relaxivity of 74.1 ± 0.3 s−1 (mM)−1, consistent with previous reports. The precision of the in vivo measurement of mean liver R2 values is tested through duplicate measurements on 10 human subjects with mean liver R2 values ranging from 26 to 220 s−1. The random uncertainty on the measurement of mean liver R2 was found to be 7.7%. Copyright © 2004 John Wiley & Sons, Ltd.

[1]  E. Purcell,et al.  Relaxation Effects in Nuclear Magnetic Resonance Absorption , 1948 .

[2]  I. Solomon.  Relaxation Processes in a System of Two Spins , 1955 .

[3]  D. Marquardt.  An Algorithm for Least-Squares Estimation of Nonlinear Parameters , 1963 .

[4]  Gabor C. Temes,et al.  Least pth Approximation , 1969 .

[5]  C. Charalambous,et al.  New Algorithms for Network Optimization , 1973 .

[6]  T. Koh,et al.  Trace element analysis of bovine liver: interlaboratory survey in Australia and New Zealand. , 1980, Journal - Association of Official Analytical Chemists.

[7]  S. H. Koenig,et al.  Relaxation of solvent protons by paramagnetic ions and its dependence on magnetic field and chemical environment: implications for NMR imaging , 1984 .

[8]  C. Gips,et al.  Measurement of iron in liver biopsies--a comparison of three analytical methods. , 1984, Clinica chimica acta; international journal of clinical chemistry.

[9]  R. Brasch,et al.  Magnetic resonance imaging of transfusional hemosiderosis complicating thalassemia major. , 1984, Radiology.

[10]  M. Moseley,et al.  Magnetic resonance imaging and spectroscopy of hepatic iron overload. , 1985, Radiology.

[11]  S. H. Koenig,et al.  Relaxometry of ferritin solutions and the influence of the Fe3+ core ions , 1986, Magnetic resonance in medicine.

[12]  William H. Press,et al.  Numerical recipes in C. The art of scientific computing , 1987 .

[13]  E M Haacke,et al.  MR artifacts: a review. , 1986, AJR. American journal of roentgenology.

[14]  K. Gersonde,et al.  In vitro proton T1 and T2 studies on rat liver: Analysis of multiexponential relaxation processes , 1986, Magnetic resonance in medicine.

[15]  S. H. Koenig,et al.  Transverse relaxation of solvent protons induced by magnetized spheres: Application to ferritin, erythrocytes, and magnetite , 1987, Magnetic resonance in medicine.

[16]  R M Henkelman,et al.  Overcoming motion in abdominal MR imaging. , 1988, AJR. American journal of roentgenology.

[17]  R. Grossman,et al.  MR relaxation times and iron content of thalassemic spleens: an in vitro study. , 1988, AJR. American journal of roentgenology.

[18]  J. Felmlee,et al.  Adaptive technique for high-definition MR imaging of moving structures. , 1989, Radiology.

[19]  L R Schad,et al.  Evaluation of proton density by magnetic resonance imaging: phantom experiments and analysis of multiple component proton transverse relaxation. , 1990, Physics in medicine and biology.

[20]  J Szumowski,et al.  Correction of periodic motion artifacts along the slice selection axis in MRI. , 1990, IEEE transactions on medical imaging.

[21]  R. Gottschalk,et al.  Non‐invasive quantitation of liver iron‐overload by magnetic resonance imaging , 1990, British journal of haematology.

[22]  R L Ehman,et al.  Adaptive motion compensation in MR imaging without use of navigator echoes. , 1991, Radiology.

[23]  C. Thomsen,et al.  Identification of patients with hereditary haemochromatosis by magnetic resonance imaging and spectroscopic relaxation time measurements. , 1992, Magnetic resonance imaging.

[24]  William H. Press,et al.  The Art of Scientific Computing Second Edition , 1998 .

[25]  A. W. Kemp,et al.  Generalized Poisson Distributions: Properties and Applications. , 1992 .

[26]  A. Leblanc,et al.  The origin of biexponential T2 relaxation in muscle water , 1993, Magnetic resonance in medicine.

[27]  G. Radda,et al.  Assessment of hepatic iron overload in thalassemic patients by magnetic resonance spectroscopy , 1994, Hepatology.

[28]  R. Fischer,et al.  Liver iron quantification: studies in aqueous iron solutions, iron overloaded rats, and patients with hereditary hemochromatosis. , 1994, Magnetic resonance imaging.

[29]  C Andersen,et al.  Precision, accuracy, and image plane uniformity in NMR relaxation time imaging on a 1.5 T whole-body MR imaging system. , 1994, Magnetic resonance imaging.

[30]  R. Means,et al.  Extremely elevated serum ferritin levels in a university hospital: associated diseases and clinical significance. , 1995, The American journal of medicine.

[31]  T G Maris,et al.  Assessment of liver iron overload by T2-quantitative magnetic resonance imaging: correlation of T2-QMRI measurements with serum ferritin concentration and histologic grading of siderosis. , 1995, Magnetic resonance imaging.

[32]  H. Gudbjartsson,et al.  The rician distribution of noisy mri data , 1995, Magnetic resonance in medicine.

[33]  Li Tang,et al.  An improved method for MRI artifact correction due to translational motion in the imaging plane , 1995, IEEE Trans. Medical Imaging.

[34]  J. Felmlee,et al.  Orbital navigator echoes for motion measurements in magnetic resonance imaging , 1995, Magnetic resonance in medicine.

[35]  A. H. Andersen,et al.  On the Rician distribution of noisy MRI data , 1996, Magnetic resonance in medicine.

[36]  Sullivan Jl,et al.  Elevated serum ferritin levels: associated diseases and clinical significance. , 1996 .

[37]  J. Juncà,et al.  Elevated serum ferritin levels: associated diseases and clinical significance. , 1996, The American journal of medicine.

[38]  R.A. Zoroofi,et al.  MRI artifact cancellation due to rigid motion in the imaging plane , 1996, IEEE Trans. Medical Imaging.

[39]  J. Villeneuve,et al.  Variability in hepatic iron concentration measurement from needle-biopsy specimens. , 1996, Journal of hepatology.

[40]  David Atkinson,et al.  Automatic correction of motion artifacts in magnetic resonance images using an entropy focus criterion , 1997, IEEE Transactions on Medical Imaging.

[41]  J A Frank,et al.  Hepatic hemosiderosis in non‐human primates: Quantification of liver iron using different field strengths , 1997, Magnetic resonance in medicine.

[42]  M. Worwood.  The laboratory assessment of iron status--an update. , 1997, Clinica chimica acta; international journal of clinical chemistry.

[43]  J. Sijbers,et al.  Signal and noise estimation from magnetic resonance images , 1998 .

[44]  R. Shiavi,et al.  Evaluation of linear diaphragm-chest expansion models for magnetic resonance imaging motion artifact correction. , 1999, Computers in biology and medicine.

[45]  M. Bronner,et al.  Quantitative study of the variability of hepatic iron concentrations. , 1999, Clinical chemistry.

[46]  A. Gouliamos,et al.  Quantification of liver iron overload by T2 quantitative magnetic resonance imaging in thalassemia: impact of chronic hepatitis C on measurements. , 1999, Journal of pediatric hematology/oncology.

[47]  T. S. St. Pierre,et al.  Quantitative mapping of transverse relaxivity (1/T(2)) in hepatic iron overload: a single spin-echo imaging methodology. , 2000, Magnetic resonance imaging.

[48]  A. Manduca,et al.  Autocorrection in MR imaging: adaptive motion correction without navigator echoes. , 2000, Radiology.

[49]  S J Riederer,et al.  Image metric‐based correction (Autocorrection) of motion effects: Analysis of image metrics , 2000, Journal of magnetic resonance imaging : JMRI.

[50]  Weifang Yang,et al.  Using an MRI distortion transfer function to characterize the ghosts in motion-corrupted images , 2000, IEEE Transactions on Medical Imaging.

[51]  S. Sheth,et al.  Noninvasive methods for quantitative assessment of transfusional iron overload in sickle cell disease. , 2001, Seminars in hematology.

[52]  D N Firmin,et al.  Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. , 2001, European heart journal.

[53]  R G Spencer,et al.  The lever-coil: a simple, inexpensive sensor for respiratory and cardiac motion in MRI experiments. , 2001, Magnetic resonance imaging.

[54]  A. Roch,et al.  Anomalous nuclear magnetic relaxation of aqueous solutions of ferritin: An unprecedented first‐order mechanism , 2002, Magnetic resonance in medicine.

[55]  James R. Moore,et al.  Evaluation of iron overload by single voxel MRS measurement of liver T2 , 2002, Journal of magnetic resonance imaging : JMRI.

[56]  R. Chandra,et al.  Theory of nonexponential NMR signal decay in liver with iron overload or superparamagnetic iron oxide particles , 2002, Magnetic resonance in medicine.

[57]  T. S. St. Pierre,et al.  Proton transverse relaxation rate (R2) images of iron‐loaded liver tissuepping local tissue iron concentrations with MRI , 2003 .

[58]  T. S. St. Pierre,et al.  Bi-exponential proton transverse relaxation rate (R2) image analysis using RF field intensity-weighted spin density projection: potential for R2 measurement of iron-loaded liver. , 2003, Magnetic resonance imaging.

[59]  G. Brittenham,et al.  Noninvasive measurement of iron: report of an NIDDK workshop. , 2003, Blood.

[60]  T. S. St. Pierre,et al.  Reduction of respiratory motion artifacts in transverse relaxation rate (R2) images of the liver. , 2004, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.

[61]  T. Meade,et al.  Mimicking liver iron overload using liposomal ferritin preparations , 2004, Magnetic resonance in medicine.