The p38 MAPK NF-κB pathway, not the ERK pathway, is involved in exogenous HIV-1 Tat-induced apoptotic cell death in retinal pigment epithelial cells.

[1]  P. Rustin,et al.  HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase , 2012, Cell Death and Disease.

[2]  L. da Cruz,et al.  Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19. , 2011, Investigative ophthalmology & visual science.

[3]  G. Olmos,et al.  TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB , 2011, Molecular and Cellular Neuroscience.

[4]  N. Chatterjee,et al.  HIV-1 Tat-Mediated Neurotoxicity in Retinal Cells , 2011, Journal of Neuroimmune Pharmacology.

[5]  Quan Zhu,et al.  Unusual life-threatening Rosai–Dorfman disease of the trachea: role of NF-κB , 2010, Thorax.

[6]  Jianguo Wu,et al.  Mechanism of HIV‐1‐TAT induction of interleukin‐1β from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade , 2010, Journal of medical virology.

[7]  J. Tuo,et al.  The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. , 2010, Experimental eye research.

[8]  L. Quinton,et al.  NF-κB and STAT3 signaling hubs for lung innate immunity , 2010, Cell and Tissue Research.

[9]  Aljoscha,et al.  Cytoprotective effects of a blue light-filtering intraocular lens on human retinal pigment epithelium by reducing phototoxic effects on vascular endothelial growth factor-a , Bax , and Bcl-2 expression , 2012 .

[10]  Lin Bai,et al.  Inducible nitric oxide synthase is involved in the oxidation stress induced by HIV-1 gp120 in human retina pigment epithelial cells. , 2008, Chinese medical journal.

[11]  Haotian Lin,et al.  HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study , 2008, BMC infectious diseases.

[12]  M. Feldmann,et al.  Rac mediates TNF-induced cytokine production via modulation of NF-kappaB. , 2008, Molecular immunology.

[13]  Jinny Park,et al.  Tumor necrosis factor-α enhances DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK pathway , 2008, International journal of hematology.

[14]  N. Ford,et al.  Cytomegalovirus Retinitis: The Neglected Disease of the AIDS Pandemic , 2007, PLoS medicine.

[15]  S. Jeansson,et al.  CMV quantitative PCR in the diagnosis of CMV disease in patients with HIV-infection – a retrospective autopsy based study , 2007, BMC infectious diseases.

[16]  M. Raizman,et al.  Anterior segment and external ocular disorders associated with human immunodeficiency virus disease. , 2007, Survey of ophthalmology.

[17]  G. Jaffe,et al.  Caspase-8-mediated apoptosis in human RPE cells. , 2007, Investigative ophthalmology & visual science.

[18]  K. Lichtenstein,et al.  HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms , 2007, AIDS research and therapy.

[19]  Shu Chen,et al.  [Characteristics of ophthalmic symptoms in the 278 patients with human immunodeficiency virus]. , 2007, [Zhonghua yan ke za zhi] Chinese journal of ophthalmology.

[20]  G. Camussi,et al.  HIV-1 Tat reduces nephrin in human podocytes: a potential mechanism for enhanced glomerular permeability in HIV-associated nephropathy , 2007, AIDS.

[21]  B. Kuppermann,et al.  Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. , 2006, Investigative ophthalmology & visual science.

[22]  J. Berman,et al.  HIV tat and neurotoxicity. , 2006, Microbes and infection.

[23]  D. Allan Butterfield,et al.  HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations , 2005, Brain Research Reviews.

[24]  M. Bähr,et al.  HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis , 2005, Neurobiology of Disease.

[25]  Chuanful Li,et al.  HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[26]  W. Freeman,et al.  HIV-ASSOCIATED RETINOPATHY IN THE HAART ERA , 2005, Retina.

[27]  Eddy Pasquier,et al.  The Glutamine-rich Region of the HIV-1 Tat Protein Is Involved in T-cell Apoptosis* , 2004, Journal of Biological Chemistry.

[28]  H. Petty,et al.  Activated Monocytes Induce Human Retinal Pigment Epithelial Cell Apoptosis Through Caspase-3 Activation , 2003, Laboratory Investigation.

[29]  H. Doerr,et al.  Human cytomegalovirus retinitis: pathogenicity, immune evasion and persistence. , 2003, Trends in Microbiology.

[30]  Y. Koh,et al.  HIV-1 Tat-Mediated Apoptosis in Human Brain Microvascular Endothelial Cells1 , 2003, The Journal of Immunology.

[31]  D. Trono,et al.  Hide, shield and strike back: how HIV-infected cells avoid immune eradication , 2003, Nature Reviews Immunology.

[32]  M. Mattson,et al.  Calcium Dysregulation and Neuronal Apoptosis by the HIV‐1 Proteins Tat and gp120 , 2002, Journal of acquired immune deficiency syndromes.

[33]  D. Noonan,et al.  HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. , 2001, Biochemical and biophysical research communications.

[34]  S. Whitcup,et al.  Ocular manifestations of HIV infection. , 1999, Current opinion in ophthalmology.

[35]  Michael Karin,et al.  Is NF‐κB the sensor of oxidative stress? , 1999 .

[36]  M. Karin,et al.  Is NF-kappaB the sensor of oxidative stress? , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  S. Donahue.  Human immunodeficiency virus-associated vision loss: electroretinogram attenuation. , 1998, American journal of ophthalmology.

[38]  M. V. Heiden,et al.  Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria , 1997, Cell.

[39]  P. Bernstein,et al.  A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture. , 1995, Investigative ophthalmology & visual science.