Time series analyses of respiratory responses to indoor and outdoor environmental phenomena.

A time series analysis was utilized to evaluate respiratory responses to outdoor and indoor air pollutant and aeroallergen exposures in potentially sensitive adults in a dry arid environment. Daily symptoms and peak flows were recorded in populations of asthmatics, allergic individuals, those with chronic lung disease symptoms, and asymptomatic individuals (total sample size of 204) over a period of a few years. Meteorology and ambient pollutant concentrations were measured in the basin. Indoor pollutant measurements were made for particulates and CO, indicating that gas stoves and tobacco smoking were the predominant indoor sources. Time series analysis helped determine appropriate lags between environmental stimuli and health responses. Asthmatics showed that most respiratory responses while asymptomatics showed no significant responses. Outdoor ozone, nitrogen dioxide, aeroallergens and meteorology, and indoor gas stoves were significantly related, independently and interactively, with symptoms and peak flow.

[1]  J. Stebbings.  Panel studies of acute health effects of air pollution. II. A methodologic study of linear regression analysis of asthma panel data. , 1978, Environmental research.

[2]  Air pollution, weather, and illness in a New York population. , 1969, Archives of environmental health.

[3]  M. Lebowitz,et al.  Analysis of relationships between symptoms and environmental factors over time. , 1984, Environmental research.

[4]  M. Lebowitz,et al.  Multivariate analysis of ambient environmental factors and respiratory effects. , 1987, International journal of epidemiology.

[5]  V. Hasselblad,et al.  SO/sub 2/ levels and perturbations in mortality , 1973 .

[6]  V. Hasselblad,et al.  SO2 levels and perturbations in mortality. A study in the New York-New Jersey metropolis. , 1973, Archives of environmental health.

[7]  M. Lebowitz,et al.  Significance of intraindividual changes in maximum expiratory flow volume and peak expiratory flow measurements. , 1982, Chest.

[8]  M. Lebowitz,et al.  Indoor-outdoor air pollution, allergen and meteorological monitoring in an arid Southwest area. , 1984, Journal of the Air Pollution Control Association.

[9]  M. Lebowitz.  The effects of environmental tobacco smoke exposure and gas stoves on daily peak flow rates in asthmatic and non-asthmatic families. , 1984, European journal of respiratory diseases. Supplement.

[10]  T. W. Anderson,et al.  Statistical analysis of time series , 1972 .

[11]  A comparative analysis of the stimulus-response relationship between mortality and air pollution-weather. , 1973, Environmental research.

[12]  M. Lebowitz,et al.  The adverse health effects of biological aerosols, other aerosols, and indoor microclimate on asthmatics and nonasthmatics , 1982 .

[13]  M. Lebowitz,et al.  Respiratory symptoms and peak flow associated with indoor and outdoor air pollutants in the southwest. , 1985, Journal of the Air Pollution Control Association.

[14]  J. Goldsmith,et al.  AIR POLLUTION AND DAILY MORTALITY , 1961, The American journal of the medical sciences.

[15]  A S Whittemore,et al.  Asthma and air pollution in the Los Angeles area. , 1980, American journal of public health.