Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies

Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis requires prompt diagnosis and treatment, since renal function at the time of diagnosis is significantly associated with renal outcomes. Here, we report two pediatric patients with ANCA-positive glomerulonephritis initially presenting with hematuria, mild proteinuria

[1]  P. V. van Daele,et al.  The value of anti-neutrophil cytoplasmic antibodies (ANCA) testing for the diagnosis of ANCA-associated vasculitis, a systematic review and meta-analysis. , 2020, Autoimmunity reviews.

[2]  J. C. Jennette,et al.  ANCA Glomerulonephritis and Vasculitis. , 2017, Clinical journal of the American Society of Nephrology : CJASN.

[3]  W. Boersma,et al.  Diagnosing ANCA-associated vasculitis in ANCA positive patients , 2016, Medicine.

[4]  D. Schroeder,et al.  Factors Determining the Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3 , 2016, Arthritis & rheumatology.

[5]  D. Jayne,et al.  Progress in treatment of ANCA-associated vasculitis , 2012, Arthritis Research & Therapy.

[6]  A. Gaffo.  Diagnostic approach to ANCA-associated vasculitides. , 2010, Rheumatic diseases clinics of North America.

[7]  D. Abramowicz,et al.  Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. , 2007, Journal of the American Society of Nephrology : JASN.

[8]  C. Pusey,et al.  Outcome of ANCA-associated renal vasculitis: a 5-year retrospective study. , 2003, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[9]  J. Jennette.  Rapidly progressive crescentic glomerulonephritis. , 2003, Kidney international.

[10]  H. V. van Houwelingen,et al.  An index for renal outcome in ANCA-associated glomerulonephritis. , 2003, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[11]  H. V. van Houwelingen,et al.  Determinants of outcome in ANCA-associated glomerulonephritis: a prospective clinico-histopathological analysis of 96 patients. , 2002, Kidney international.

[12]  F. Gök,et al.  Ceruloplasmin levels in antineutrophil cytoplasmic antibody-positive patients , 2002, Pediatric Nephrology.

[13]  P Lesavre,et al.  Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR Project for ANCA Assay Standardization. , 1998, Kidney international.

[14]  C. Hallahan,et al.  Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with Wegener's granulomatosis. , 1993, Arthritis and rheumatism.

[15]  H. Corwin,et al.  Microscopic hematuria. , 1988, Clinics in laboratory medicine.